Rationale for folate receptor alpha targeted therapy in "high risk" endometrial carcinomas

Monica Brown Jones, Christina Neuper, Amy Clayton, Andrea Mariani, Gottfried Konecny, M. Bijoy Thomas, Gary Keeney, Lynn Hartmann, Karl C. Podratz

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

Advanced and recurrent endometrial cancers account for the majority of deaths from this disease with limited therapeutic options. High grade, and nonendometrioid histology, pathologically characterize the endometrial tumors associated with adverse outcome and are classified as "high risk". The identification of molecular prognostic factors that might be targeted for therapy among "high risk" endometrial cancers is an active area of investigation. We hypothesize that the FRα, highly expressed in endometrial cancer cells, is a potential target for this disease. Our objectives were to determine if FRα overexpression is associated with adverse prognostic factors and worse outcome. Three hundred and thirty-two endometrial cancer cores were arrayed onto a tissue microarray and stained using a FRα-specific monoclonal antibody. Staining was scored as absent or weak and moderate or strong. Forty-one percent of 310 evaluable cases stained moderate/strong. Moderate/strong FRα staining was significantly associated with other poor prognostic factors including: advanced stage, nonendometrioid histology and high grade. An association was observed between moderate/strong FRα staining and recurrence (p < 0.0014). These findings support further exploring a role for FRα targeted approaches for therapy and diagnostics in endometrial cancer.

Original languageEnglish (US)
Pages (from-to)1699-1703
Number of pages5
JournalInternational Journal of Cancer
Volume123
Issue number7
DOIs
StatePublished - Oct 1 2008

Keywords

  • Endometrial carcinoma
  • Folate receptor alpha
  • Targeted therapy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Jones, M. B., Neuper, C., Clayton, A., Mariani, A., Konecny, G., Thomas, M. B., Keeney, G., Hartmann, L., & Podratz, K. C. (2008). Rationale for folate receptor alpha targeted therapy in "high risk" endometrial carcinomas. International Journal of Cancer, 123(7), 1699-1703. https://doi.org/10.1002/ijc.23686