Rationale for catheter directed therapy in pulmonary embolism

Sailendra Naidu, Grace Knuttinen, J. Scott Kriegshauser, William G. Eversman, Rahmi Oklu

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Pulmonary embolism (PE) is a widespread health concern associated with major morbidity and mortality. Catheter directed therapy (CDT) has emerged as a treatment option for acute PE adding to the current potential options of systemic thrombolysis or anticoagulation. The purpose of this review is to understand the rationale and indications for CDT in patients with PE. While numerous studies have shown the benefits of systemic thrombolysis compared to standard anticoagulation, these are balanced by the increased risk of major bleeding. With this in mind, CDT has the potential to offer the benefits of systemic thrombolysis and in theory, a reduced risk of bleeding. This article will review current treatment guidelines in both massive and submassive PE evaluating both short and long term benefits. The role of CDT will be highlighted, with an emphasis on efficacy and safety.

Original languageEnglish (US)
Pages (from-to)S320-S328
JournalCardiovascular Diagnosis and Therapy
Volume7
DOIs
StatePublished - Dec 1 2017

Fingerprint

Pulmonary Embolism
Catheters
Therapeutics
Hemorrhage
Guidelines
Morbidity
Safety
Mortality
Health

Keywords

  • Catheter directed therapy (CDT)
  • Pulmonary embolism (PE)
  • Thrombolytic therapy

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Rationale for catheter directed therapy in pulmonary embolism. / Naidu, Sailendra; Knuttinen, Grace; Kriegshauser, J. Scott; Eversman, William G.; Oklu, Rahmi.

In: Cardiovascular Diagnosis and Therapy, Vol. 7, 01.12.2017, p. S320-S328.

Research output: Contribution to journalReview article

@article{8eec1f4295114edba685ccb90bc34207,
title = "Rationale for catheter directed therapy in pulmonary embolism",
abstract = "Pulmonary embolism (PE) is a widespread health concern associated with major morbidity and mortality. Catheter directed therapy (CDT) has emerged as a treatment option for acute PE adding to the current potential options of systemic thrombolysis or anticoagulation. The purpose of this review is to understand the rationale and indications for CDT in patients with PE. While numerous studies have shown the benefits of systemic thrombolysis compared to standard anticoagulation, these are balanced by the increased risk of major bleeding. With this in mind, CDT has the potential to offer the benefits of systemic thrombolysis and in theory, a reduced risk of bleeding. This article will review current treatment guidelines in both massive and submassive PE evaluating both short and long term benefits. The role of CDT will be highlighted, with an emphasis on efficacy and safety.",
keywords = "Catheter directed therapy (CDT), Pulmonary embolism (PE), Thrombolytic therapy",
author = "Sailendra Naidu and Grace Knuttinen and Kriegshauser, {J. Scott} and Eversman, {William G.} and Rahmi Oklu",
year = "2017",
month = "12",
day = "1",
doi = "10.21037/cdt.2017.08.14",
language = "English (US)",
volume = "7",
pages = "S320--S328",
journal = "Cardiovascular Diagnosis and Therapy",
issn = "2223-3652",
publisher = "AME Publishing Company",

}

TY - JOUR

T1 - Rationale for catheter directed therapy in pulmonary embolism

AU - Naidu, Sailendra

AU - Knuttinen, Grace

AU - Kriegshauser, J. Scott

AU - Eversman, William G.

AU - Oklu, Rahmi

PY - 2017/12/1

Y1 - 2017/12/1

N2 - Pulmonary embolism (PE) is a widespread health concern associated with major morbidity and mortality. Catheter directed therapy (CDT) has emerged as a treatment option for acute PE adding to the current potential options of systemic thrombolysis or anticoagulation. The purpose of this review is to understand the rationale and indications for CDT in patients with PE. While numerous studies have shown the benefits of systemic thrombolysis compared to standard anticoagulation, these are balanced by the increased risk of major bleeding. With this in mind, CDT has the potential to offer the benefits of systemic thrombolysis and in theory, a reduced risk of bleeding. This article will review current treatment guidelines in both massive and submassive PE evaluating both short and long term benefits. The role of CDT will be highlighted, with an emphasis on efficacy and safety.

AB - Pulmonary embolism (PE) is a widespread health concern associated with major morbidity and mortality. Catheter directed therapy (CDT) has emerged as a treatment option for acute PE adding to the current potential options of systemic thrombolysis or anticoagulation. The purpose of this review is to understand the rationale and indications for CDT in patients with PE. While numerous studies have shown the benefits of systemic thrombolysis compared to standard anticoagulation, these are balanced by the increased risk of major bleeding. With this in mind, CDT has the potential to offer the benefits of systemic thrombolysis and in theory, a reduced risk of bleeding. This article will review current treatment guidelines in both massive and submassive PE evaluating both short and long term benefits. The role of CDT will be highlighted, with an emphasis on efficacy and safety.

KW - Catheter directed therapy (CDT)

KW - Pulmonary embolism (PE)

KW - Thrombolytic therapy

UR - http://www.scopus.com/inward/record.url?scp=85038614114&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85038614114&partnerID=8YFLogxK

U2 - 10.21037/cdt.2017.08.14

DO - 10.21037/cdt.2017.08.14

M3 - Review article

AN - SCOPUS:85038614114

VL - 7

SP - S320-S328

JO - Cardiovascular Diagnosis and Therapy

JF - Cardiovascular Diagnosis and Therapy

SN - 2223-3652

ER -