Rationale and design of the Kronos Early Estrogen Prevention Study (KEEPS) and the KEEPS cognitive and affective sub study (KEEPS Cog)

Whitney Wharton, Carey E. Gleason, Virginia M Miller, Sanjay Asthana

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

This manuscript describes the study design and rationalle for the Kronos Early Estrogen Prevention Study (KEEPS) and the KEEPS Cognitive and Affective ancillary study (KEEPS Cog). KEEPS is a multicenter, randomized, double-blinded, placebo-controlled trial, designed to test the hypothesis that low-dose hormone therapy (HT) initiated in recently postmenopausal women will reduce the progression of subclinical atherosclerosis as measured by carotid artery intima-media thickness (CIMT) and coronary artery calcification (CAC) over four years. The KEEPS Cog ancillary study was designed to assess potential estrogenic treatment effects on cognition and mood. We present the KEEPS trial in the context of issues raised by the Women's Health Initiative (WHI) and the Women's Health Initiative Memory Study (WHIMS). Here we also describe the most recent results and ongoing HT-related research studies designed to address similar issues. This article is part of a Special Issue entitled Hormone Therapy.

Original languageEnglish (US)
Pages (from-to)12-17
Number of pages6
JournalBrain Research
Volume1514
DOIs
StatePublished - Jun 13 2013

Fingerprint

Estrogens
Women's Health
Hormones
Carotid Intima-Media Thickness
Therapeutics
Carotid Arteries
Cognition
Atherosclerosis
Coronary Vessels
Placebos
Research

Keywords

  • Alzheimer's disease
  • Clinical trial
  • Cognition
  • Estrogen
  • Hormone therapy
  • KEEPS
  • Menopause

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology
  • Developmental Biology
  • Molecular Biology

Cite this

Rationale and design of the Kronos Early Estrogen Prevention Study (KEEPS) and the KEEPS cognitive and affective sub study (KEEPS Cog). / Wharton, Whitney; Gleason, Carey E.; Miller, Virginia M; Asthana, Sanjay.

In: Brain Research, Vol. 1514, 13.06.2013, p. 12-17.

Research output: Contribution to journalArticle

@article{1d0093f6e3fc4b6a934007c44b9c876b,
title = "Rationale and design of the Kronos Early Estrogen Prevention Study (KEEPS) and the KEEPS cognitive and affective sub study (KEEPS Cog)",
abstract = "This manuscript describes the study design and rationalle for the Kronos Early Estrogen Prevention Study (KEEPS) and the KEEPS Cognitive and Affective ancillary study (KEEPS Cog). KEEPS is a multicenter, randomized, double-blinded, placebo-controlled trial, designed to test the hypothesis that low-dose hormone therapy (HT) initiated in recently postmenopausal women will reduce the progression of subclinical atherosclerosis as measured by carotid artery intima-media thickness (CIMT) and coronary artery calcification (CAC) over four years. The KEEPS Cog ancillary study was designed to assess potential estrogenic treatment effects on cognition and mood. We present the KEEPS trial in the context of issues raised by the Women's Health Initiative (WHI) and the Women's Health Initiative Memory Study (WHIMS). Here we also describe the most recent results and ongoing HT-related research studies designed to address similar issues. This article is part of a Special Issue entitled Hormone Therapy.",
keywords = "Alzheimer's disease, Clinical trial, Cognition, Estrogen, Hormone therapy, KEEPS, Menopause",
author = "Whitney Wharton and Gleason, {Carey E.} and Miller, {Virginia M} and Sanjay Asthana",
year = "2013",
month = "6",
day = "13",
doi = "10.1016/j.brainres.2013.04.011",
language = "English (US)",
volume = "1514",
pages = "12--17",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier",

}

TY - JOUR

T1 - Rationale and design of the Kronos Early Estrogen Prevention Study (KEEPS) and the KEEPS cognitive and affective sub study (KEEPS Cog)

AU - Wharton, Whitney

AU - Gleason, Carey E.

AU - Miller, Virginia M

AU - Asthana, Sanjay

PY - 2013/6/13

Y1 - 2013/6/13

N2 - This manuscript describes the study design and rationalle for the Kronos Early Estrogen Prevention Study (KEEPS) and the KEEPS Cognitive and Affective ancillary study (KEEPS Cog). KEEPS is a multicenter, randomized, double-blinded, placebo-controlled trial, designed to test the hypothesis that low-dose hormone therapy (HT) initiated in recently postmenopausal women will reduce the progression of subclinical atherosclerosis as measured by carotid artery intima-media thickness (CIMT) and coronary artery calcification (CAC) over four years. The KEEPS Cog ancillary study was designed to assess potential estrogenic treatment effects on cognition and mood. We present the KEEPS trial in the context of issues raised by the Women's Health Initiative (WHI) and the Women's Health Initiative Memory Study (WHIMS). Here we also describe the most recent results and ongoing HT-related research studies designed to address similar issues. This article is part of a Special Issue entitled Hormone Therapy.

AB - This manuscript describes the study design and rationalle for the Kronos Early Estrogen Prevention Study (KEEPS) and the KEEPS Cognitive and Affective ancillary study (KEEPS Cog). KEEPS is a multicenter, randomized, double-blinded, placebo-controlled trial, designed to test the hypothesis that low-dose hormone therapy (HT) initiated in recently postmenopausal women will reduce the progression of subclinical atherosclerosis as measured by carotid artery intima-media thickness (CIMT) and coronary artery calcification (CAC) over four years. The KEEPS Cog ancillary study was designed to assess potential estrogenic treatment effects on cognition and mood. We present the KEEPS trial in the context of issues raised by the Women's Health Initiative (WHI) and the Women's Health Initiative Memory Study (WHIMS). Here we also describe the most recent results and ongoing HT-related research studies designed to address similar issues. This article is part of a Special Issue entitled Hormone Therapy.

KW - Alzheimer's disease

KW - Clinical trial

KW - Cognition

KW - Estrogen

KW - Hormone therapy

KW - KEEPS

KW - Menopause

UR - http://www.scopus.com/inward/record.url?scp=84878500301&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84878500301&partnerID=8YFLogxK

U2 - 10.1016/j.brainres.2013.04.011

DO - 10.1016/j.brainres.2013.04.011

M3 - Article

C2 - 23603409

AN - SCOPUS:84878500301

VL - 1514

SP - 12

EP - 17

JO - Brain Research

JF - Brain Research

SN - 0006-8993

ER -