TY - JOUR
T1 - Rationale and Design for the D iabetes RE lated to A cute Pancreatitis and Its M echanisms Study
T2 - A Prospective Cohort Study from the Type 1 Diabetes in Acute Pancreatitis Consortium
AU - Type 1 Diabetes in Acute Pancreatitis Consortium (T1DAPC)
AU - Hart, Phil A.
AU - Papachristou, Georgios I.
AU - Park, Walter G.
AU - Dyer, Anne Marie
AU - Chinchilli, Vernon M.
AU - Afghani, Elham
AU - Akshintala, Venkata S.
AU - Andersen, Dana K.
AU - Buxbaum, James L.
AU - Conwell, Darwin L.
AU - Dungan, Kathleen M.
AU - Easler, Jeffrey J.
AU - Fogel, Evan L.
AU - Greenbaum, Carla J.
AU - Kalyani, Rita R.
AU - Korc, Murray
AU - Kozarek, Richard
AU - Laughlin, Maren R.
AU - Lee, Peter J.
AU - Maranki, Jennifer L.
AU - Pandol, Stephen J.
AU - Phillips, Anna Evans
AU - Serrano, Jose
AU - Singh, Vikesh K.
AU - Speake, Cate
AU - Tirkes, Temel
AU - Toledo, Frederico G.S.
AU - Trikudanathan, Guru
AU - Vege, Santhi Swaroop
AU - Wang, Ming
AU - Yazici, Cemal
AU - Zaheer, Atif
AU - Forsmark, Christopher E.
AU - Bellin, Melena D.
AU - Yadav, Dhiraj
N1 - Publisher Copyright:
© Wolters Kluwer Health, Inc. All rights reserved.
PY - 2022/7/1
Y1 - 2022/7/1
N2 - Acute pancreatitis (AP) is a disease characterized by an acute inflammatory phase followed by a convalescent phase. Diabetes mellitus (DM) was historically felt to be a transient phenomenon related to acute inflammation; however, it is increasingly recognized as an important late and chronic complication. There are several challenges that have prevented precisely determining the incidence rate of DM after AP and understanding the underlying mechanisms. The DREAM (Diabetes RElated to Acute Pancreatitis and its Mechanisms) Study is a prospective cohort study designed to address these and other knowledge gaps to provide the evidence needed to screen for, prevent, and treat DM after AP. In the following article, we summarize literature regarding the epidemiology of DM after AP and provide the rationale and an overview of the DREAM study.
AB - Acute pancreatitis (AP) is a disease characterized by an acute inflammatory phase followed by a convalescent phase. Diabetes mellitus (DM) was historically felt to be a transient phenomenon related to acute inflammation; however, it is increasingly recognized as an important late and chronic complication. There are several challenges that have prevented precisely determining the incidence rate of DM after AP and understanding the underlying mechanisms. The DREAM (Diabetes RElated to Acute Pancreatitis and its Mechanisms) Study is a prospective cohort study designed to address these and other knowledge gaps to provide the evidence needed to screen for, prevent, and treat DM after AP. In the following article, we summarize literature regarding the epidemiology of DM after AP and provide the rationale and an overview of the DREAM study.
KW - AP - acute pancreatitis
KW - CP - chronic pancreatitis
KW - DCC - data coordinating center
KW - DM - diabetes mellitus
KW - DREAM - Diabetes RElated to Acute pancreatitis and its Mechanisms
KW - FSIGTT - frequently sampled intravenous glucose tolerance testing
KW - MMTT - mixed meal tolerance testing
KW - OGTT - oral glucose tolerance testing
KW - T1DAPC - Type 1 Diabetes in Acute Pancreatitis Consortium
KW - autoantibody
KW - beta cell
KW - epidemiology
KW - insulin
KW - pancreatogenic diabetes
KW - type 3c diabetes
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U2 - 10.1097/MPA.0000000000002079
DO - 10.1097/MPA.0000000000002079
M3 - Article
C2 - 36206460
AN - SCOPUS:85139572032
SN - 0885-3177
VL - 51
SP - 568
EP - 574
JO - Pancreas
JF - Pancreas
IS - 6
ER -