Ratio of hepatic arterial-to-portal venous blood flow - Validation of radionuclide techniques in an animal model

M. K. O'Connor, R. F. Krom, E. G. Carton, L. Sanchez-Urdazpal, J. E. Juni, D. M. Ferguson, R. F. Wiesner

Research output: Contribution to journalArticle

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Abstract

The ratio of hepatic arterial-to-portal venous blood flow can be determined from the analysis of a first-pass bolus through the liver by a number of techniques. This study examines the validity of four radiotracer techniques in an animal model. Thirty-four flow studies (3 mCi 99mTc- DTPA/study) were performed in seven anesthetized pigs. Images were acquired for 200 sec and time-activity curves were generated from lung, liver and kidney ROIs. These curves were analyzed using a slope-based (HPI), a height- based (mHAR) and two deconvolution-based methods employing exponential or gamma variate fits. There was an excellent correlation (r > 0.9) between results obtained with flow probes and the radiotracer techniques, with the exception of the HPI technique (r = 0.75). The mHAR and deconvolution techniques were inaccurate at very low and high arterial flows, due respectively to noise limitations and hemodynamic instability in the animal. Nevertheless, these techniques appear to be the most promising for routine clinical use.

Original languageEnglish (US)
Pages (from-to)239-245
Number of pages7
JournalJournal of Nuclear Medicine
Volume33
Issue number2
StatePublished - 1992

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Radioisotopes
Animal Models
Liver
Pentetic Acid
Noise
Swine
Hemodynamics
Kidney
Lung

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

O'Connor, M. K., Krom, R. F., Carton, E. G., Sanchez-Urdazpal, L., Juni, J. E., Ferguson, D. M., & Wiesner, R. F. (1992). Ratio of hepatic arterial-to-portal venous blood flow - Validation of radionuclide techniques in an animal model. Journal of Nuclear Medicine, 33(2), 239-245.

Ratio of hepatic arterial-to-portal venous blood flow - Validation of radionuclide techniques in an animal model. / O'Connor, M. K.; Krom, R. F.; Carton, E. G.; Sanchez-Urdazpal, L.; Juni, J. E.; Ferguson, D. M.; Wiesner, R. F.

In: Journal of Nuclear Medicine, Vol. 33, No. 2, 1992, p. 239-245.

Research output: Contribution to journalArticle

O'Connor, MK, Krom, RF, Carton, EG, Sanchez-Urdazpal, L, Juni, JE, Ferguson, DM & Wiesner, RF 1992, 'Ratio of hepatic arterial-to-portal venous blood flow - Validation of radionuclide techniques in an animal model', Journal of Nuclear Medicine, vol. 33, no. 2, pp. 239-245.
O'Connor MK, Krom RF, Carton EG, Sanchez-Urdazpal L, Juni JE, Ferguson DM et al. Ratio of hepatic arterial-to-portal venous blood flow - Validation of radionuclide techniques in an animal model. Journal of Nuclear Medicine. 1992;33(2):239-245.
O'Connor, M. K. ; Krom, R. F. ; Carton, E. G. ; Sanchez-Urdazpal, L. ; Juni, J. E. ; Ferguson, D. M. ; Wiesner, R. F. / Ratio of hepatic arterial-to-portal venous blood flow - Validation of radionuclide techniques in an animal model. In: Journal of Nuclear Medicine. 1992 ; Vol. 33, No. 2. pp. 239-245.
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