Rates of bone loss in the appendicular and axial skeletons of women. Evidence of substantial vertebral bone loss before menopause

B. L. Riggs, H. W. Wahner, L. J. Melton, L. S. Richelson, H. L. Judd, K. P. Offord

Research output: Contribution to journalArticle

408 Scopus citations

Abstract

We made longitudinal measurements of bone mineral density (BMD) in 139 normal women (ages 20-88 yr) at midradius (99% cortical bone) and lumbar spine (~70% trabecular bone) by single- and dual-photon absorptiometry. BMD was measured 2-6 (median, 3) times over an interval of 0.8-3.4 yr (median, 2.1 yr). For midradius, BMD did not change (+0.48%/yr, NS) before menopause but decreased (-1.01%/yr, P < 0.001) after menopause. For lumbar spine, there was significant bone loss both before (-1.32%/yr, P < 0.001) and after (-0.97%/yr, P = 0.006) menopause; these rates did not differ significantly from each other. Our data show that before menopause little, if any, bone is lost from the appendicular skeleton but substantial amounts are lost from the axial skeleton. Thus, factors in addition to estrogen deficiency must contribute to pathogenesis of involutional osteoporosis in women because about half of overall vertebral bone loss occurs premenopausally.

Original languageEnglish (US)
Pages (from-to)1487-1491
Number of pages5
JournalJournal of Clinical Investigation
Volume77
Issue number5
DOIs
StatePublished - 1986

ASJC Scopus subject areas

  • Medicine(all)

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