Ras-GTP-Raf complexes and its molecular mechanism in the signal transduction

Zhaoyu Li, Wei Zou, Zhao Chun Cui

Research output: Contribution to journalArticle

Abstract

Ras-GTP-Raf complexes play an important role in the RTKs-mediated Ras pathway. The molecular mechanism of signal transduction in the Ras-GTP-Raf complexes is that the complexes switch signal transduction, trigger signal amplification cascade and may be involved in neoplasia. In addition, Ras-GTP-Raf complexes are essential in the PKC-mediated activation of Raf.

Original languageEnglish (US)
Pages (from-to)374
Number of pages1
JournalProgress in Biochemistry and Biophysics
Volume27
Issue number4
StatePublished - 2000
Externally publishedYes

Fingerprint

Signal transduction
Guanosine Triphosphate
Signal Transduction
Switch Genes
Amplification
Chemical activation
Switches
Neoplasms

Keywords

  • Ras-GTP-Raf complexes
  • Signal transduction
  • Tumour

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics

Cite this

Ras-GTP-Raf complexes and its molecular mechanism in the signal transduction. / Li, Zhaoyu; Zou, Wei; Cui, Zhao Chun.

In: Progress in Biochemistry and Biophysics, Vol. 27, No. 4, 2000, p. 374.

Research output: Contribution to journalArticle

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