Ras-GTP-Raf complexes and its molecular mechanism in the signal transduction

Zhao Yu Li, Wei Zou, Zhao Chun Cui

Research output: Contribution to journalArticle

Abstract

Ras-GTP-Raf complexes play an important role in the RTKs-mediated Ras pathway. The molecular mechanism of signal transduction in the Ras-GTP-Raf complexes is that the complexes switch signal transduction, trigger signal amplification cascade and may be involved in neoplasia. In addition, Ras-GTP-Raf complexes are essential in the PKC-mediated activation of Raf.

Original languageEnglish (US)
Number of pages1
JournalProgress in Biochemistry and Biophysics
Volume27
Issue number4
StatePublished - Dec 1 2000

Keywords

  • Ras-GTP-Raf complexes
  • Signal transduction
  • Tumour

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry

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