Rare Pediatric Non-Hodgkin Lymphomas: A Report From Children's Oncology Group Study ANHL 04B1

Chibuzo O'Suoji, Jennifer J G Welch, Sherrie L. Perkins, Lynette M. Smith, Sheila Weitzman, Stephen J. Simko, Paul J. Galardy, Catherine M. Bollard, Thomas G. Gross, Amanda M. Termuhlen

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Background: Non-Hodgkin lymphoma (NHL) is a relatively common malignancy in pediatric patients; however, a small subgroup have unusual lymphoma subtypes for the pediatric population. Procedure: The Children's Oncology Group Rare and Cutaneous NHL registry's (protocol ANHL 04B1) main objectives were to determine the pathologic, biologic, and clinical features of rare and cutaneous pediatric NHL and establish a bank of centrally reviewed tissue specimens. We report the clinical data, treatment data, and outcome for rare pediatric NHL. Results: In 101 lymphomas, there is a 97.8% concordance between the reviewing study pathologists and an 87.6% concordance between the central and institutional pathology review. Samples in the specimen bank include primary tumor tissue that is snap frozen, in paraffin blocks, or H&E-stained and unstained paraffin slides as well as blood, serum, and bone marrow. This descriptive analysis shows that children with pediatric follicular lymphoma, mucosa-associated lymphoid tissue, nodal marginal zone lymphoma, primary cutaneous, primary central nervous system lymphoma, and subcutaneous panniculitis-like T-cell lymphomas have 100% survival at a median of 2 years from enrollment. There are early deaths, mostly from progressive disease, in subjects with peripheral T-cell (not otherwise specified), NKT, and hepatosplenic T-cell lymphomas. Conclusions: This registry provides high-quality biologic specimens with clinical data to investigators working on the biology of these unusual pediatric diseases.

Original languageEnglish (US)
Pages (from-to)794-800
Number of pages7
JournalPediatric Blood and Cancer
Volume63
Issue number5
DOIs
StatePublished - May 1 2016

Fingerprint

Non-Hodgkin's Lymphoma
Pediatrics
Lymphoma
Paraffin
Skin
Registries
Marginal Zone B-Cell Lymphoma
Follicular Lymphoma
T-Cell Lymphoma
Neoplasms
Central Nervous System
Bone Marrow
Research Personnel
Pathology
T-Lymphocytes
Survival
Serum
Population

Keywords

  • Cutaneous lymphoma
  • Follicular lymphoma
  • Non-Hodgkin lymphoma

ASJC Scopus subject areas

  • Oncology
  • Pediatrics, Perinatology, and Child Health
  • Hematology

Cite this

O'Suoji, C., Welch, J. J. G., Perkins, S. L., Smith, L. M., Weitzman, S., Simko, S. J., ... Termuhlen, A. M. (2016). Rare Pediatric Non-Hodgkin Lymphomas: A Report From Children's Oncology Group Study ANHL 04B1. Pediatric Blood and Cancer, 63(5), 794-800. https://doi.org/10.1002/pbc.25881

Rare Pediatric Non-Hodgkin Lymphomas : A Report From Children's Oncology Group Study ANHL 04B1. / O'Suoji, Chibuzo; Welch, Jennifer J G; Perkins, Sherrie L.; Smith, Lynette M.; Weitzman, Sheila; Simko, Stephen J.; Galardy, Paul J.; Bollard, Catherine M.; Gross, Thomas G.; Termuhlen, Amanda M.

In: Pediatric Blood and Cancer, Vol. 63, No. 5, 01.05.2016, p. 794-800.

Research output: Contribution to journalArticle

O'Suoji, C, Welch, JJG, Perkins, SL, Smith, LM, Weitzman, S, Simko, SJ, Galardy, PJ, Bollard, CM, Gross, TG & Termuhlen, AM 2016, 'Rare Pediatric Non-Hodgkin Lymphomas: A Report From Children's Oncology Group Study ANHL 04B1', Pediatric Blood and Cancer, vol. 63, no. 5, pp. 794-800. https://doi.org/10.1002/pbc.25881
O'Suoji C, Welch JJG, Perkins SL, Smith LM, Weitzman S, Simko SJ et al. Rare Pediatric Non-Hodgkin Lymphomas: A Report From Children's Oncology Group Study ANHL 04B1. Pediatric Blood and Cancer. 2016 May 1;63(5):794-800. https://doi.org/10.1002/pbc.25881
O'Suoji, Chibuzo ; Welch, Jennifer J G ; Perkins, Sherrie L. ; Smith, Lynette M. ; Weitzman, Sheila ; Simko, Stephen J. ; Galardy, Paul J. ; Bollard, Catherine M. ; Gross, Thomas G. ; Termuhlen, Amanda M. / Rare Pediatric Non-Hodgkin Lymphomas : A Report From Children's Oncology Group Study ANHL 04B1. In: Pediatric Blood and Cancer. 2016 ; Vol. 63, No. 5. pp. 794-800.
@article{94cec7d930ce421090216aca3c9080ba,
title = "Rare Pediatric Non-Hodgkin Lymphomas: A Report From Children's Oncology Group Study ANHL 04B1",
abstract = "Background: Non-Hodgkin lymphoma (NHL) is a relatively common malignancy in pediatric patients; however, a small subgroup have unusual lymphoma subtypes for the pediatric population. Procedure: The Children's Oncology Group Rare and Cutaneous NHL registry's (protocol ANHL 04B1) main objectives were to determine the pathologic, biologic, and clinical features of rare and cutaneous pediatric NHL and establish a bank of centrally reviewed tissue specimens. We report the clinical data, treatment data, and outcome for rare pediatric NHL. Results: In 101 lymphomas, there is a 97.8{\%} concordance between the reviewing study pathologists and an 87.6{\%} concordance between the central and institutional pathology review. Samples in the specimen bank include primary tumor tissue that is snap frozen, in paraffin blocks, or H&E-stained and unstained paraffin slides as well as blood, serum, and bone marrow. This descriptive analysis shows that children with pediatric follicular lymphoma, mucosa-associated lymphoid tissue, nodal marginal zone lymphoma, primary cutaneous, primary central nervous system lymphoma, and subcutaneous panniculitis-like T-cell lymphomas have 100{\%} survival at a median of 2 years from enrollment. There are early deaths, mostly from progressive disease, in subjects with peripheral T-cell (not otherwise specified), NKT, and hepatosplenic T-cell lymphomas. Conclusions: This registry provides high-quality biologic specimens with clinical data to investigators working on the biology of these unusual pediatric diseases.",
keywords = "Cutaneous lymphoma, Follicular lymphoma, Non-Hodgkin lymphoma",
author = "Chibuzo O'Suoji and Welch, {Jennifer J G} and Perkins, {Sherrie L.} and Smith, {Lynette M.} and Sheila Weitzman and Simko, {Stephen J.} and Galardy, {Paul J.} and Bollard, {Catherine M.} and Gross, {Thomas G.} and Termuhlen, {Amanda M.}",
year = "2016",
month = "5",
day = "1",
doi = "10.1002/pbc.25881",
language = "English (US)",
volume = "63",
pages = "794--800",
journal = "Pediatric Blood and Cancer",
issn = "1545-5009",
publisher = "Wiley-Liss Inc.",
number = "5",

}

TY - JOUR

T1 - Rare Pediatric Non-Hodgkin Lymphomas

T2 - A Report From Children's Oncology Group Study ANHL 04B1

AU - O'Suoji, Chibuzo

AU - Welch, Jennifer J G

AU - Perkins, Sherrie L.

AU - Smith, Lynette M.

AU - Weitzman, Sheila

AU - Simko, Stephen J.

AU - Galardy, Paul J.

AU - Bollard, Catherine M.

AU - Gross, Thomas G.

AU - Termuhlen, Amanda M.

PY - 2016/5/1

Y1 - 2016/5/1

N2 - Background: Non-Hodgkin lymphoma (NHL) is a relatively common malignancy in pediatric patients; however, a small subgroup have unusual lymphoma subtypes for the pediatric population. Procedure: The Children's Oncology Group Rare and Cutaneous NHL registry's (protocol ANHL 04B1) main objectives were to determine the pathologic, biologic, and clinical features of rare and cutaneous pediatric NHL and establish a bank of centrally reviewed tissue specimens. We report the clinical data, treatment data, and outcome for rare pediatric NHL. Results: In 101 lymphomas, there is a 97.8% concordance between the reviewing study pathologists and an 87.6% concordance between the central and institutional pathology review. Samples in the specimen bank include primary tumor tissue that is snap frozen, in paraffin blocks, or H&E-stained and unstained paraffin slides as well as blood, serum, and bone marrow. This descriptive analysis shows that children with pediatric follicular lymphoma, mucosa-associated lymphoid tissue, nodal marginal zone lymphoma, primary cutaneous, primary central nervous system lymphoma, and subcutaneous panniculitis-like T-cell lymphomas have 100% survival at a median of 2 years from enrollment. There are early deaths, mostly from progressive disease, in subjects with peripheral T-cell (not otherwise specified), NKT, and hepatosplenic T-cell lymphomas. Conclusions: This registry provides high-quality biologic specimens with clinical data to investigators working on the biology of these unusual pediatric diseases.

AB - Background: Non-Hodgkin lymphoma (NHL) is a relatively common malignancy in pediatric patients; however, a small subgroup have unusual lymphoma subtypes for the pediatric population. Procedure: The Children's Oncology Group Rare and Cutaneous NHL registry's (protocol ANHL 04B1) main objectives were to determine the pathologic, biologic, and clinical features of rare and cutaneous pediatric NHL and establish a bank of centrally reviewed tissue specimens. We report the clinical data, treatment data, and outcome for rare pediatric NHL. Results: In 101 lymphomas, there is a 97.8% concordance between the reviewing study pathologists and an 87.6% concordance between the central and institutional pathology review. Samples in the specimen bank include primary tumor tissue that is snap frozen, in paraffin blocks, or H&E-stained and unstained paraffin slides as well as blood, serum, and bone marrow. This descriptive analysis shows that children with pediatric follicular lymphoma, mucosa-associated lymphoid tissue, nodal marginal zone lymphoma, primary cutaneous, primary central nervous system lymphoma, and subcutaneous panniculitis-like T-cell lymphomas have 100% survival at a median of 2 years from enrollment. There are early deaths, mostly from progressive disease, in subjects with peripheral T-cell (not otherwise specified), NKT, and hepatosplenic T-cell lymphomas. Conclusions: This registry provides high-quality biologic specimens with clinical data to investigators working on the biology of these unusual pediatric diseases.

KW - Cutaneous lymphoma

KW - Follicular lymphoma

KW - Non-Hodgkin lymphoma

UR - http://www.scopus.com/inward/record.url?scp=84961262238&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84961262238&partnerID=8YFLogxK

U2 - 10.1002/pbc.25881

DO - 10.1002/pbc.25881

M3 - Article

C2 - 26728447

AN - SCOPUS:84961262238

VL - 63

SP - 794

EP - 800

JO - Pediatric Blood and Cancer

JF - Pediatric Blood and Cancer

SN - 1545-5009

IS - 5

ER -