Rare Coding Variation and Risk of Intracerebral Hemorrhage

Farid Radmanesh, Guido J. Falcone, Christopher D. Anderson, David McWilliams, William J. Devan, W. Mark Brown, Thomas W K Battey, Alison M. Ayres, Miriam R. Raffeld, Kristin Schwab, Guangyun Sun, Ranjan Deka, Anand Viswanathan, Joshua N. Goldstein, Steven M. Greenberg, David L. Tirschwell, Scott L. Silliman, Magdy Selim, James F Meschia, Devin L. BrownBradford B. Worrall, Carl D. Langefeld, Daniel Woo, Jonathan Rosand

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

BACKGROUND AND PURPOSE: Intracerebral hemorrhage has a substantial genetic component. We performed a preliminary search for rare coding variants associated with intracerebral hemorrhage.

METHODS: A total of 757 cases and 795 controls were genotyped using the Illumina HumanExome Beadchip (Illumina, Inc, San Diego, CA). Meta-analyses of single-variant and gene-based association were computed.

RESULTS: No rare coding variants were associated with intracerebral hemorrhage. Three common variants on chromosome 19q13 at an established susceptibility locus, encompassing TOMM40, APOE, and APOC1, met genome-wide significance (P

CONCLUSIONS: Although no coding variants of large effect were detected, this study further underscores a major challenge for the study of genetic susceptibility loci; large sample sizes are required for sufficient power except for loci with large effects.

Original languageEnglish (US)
Pages (from-to)2299-2301
Number of pages3
JournalStroke
Volume46
Issue number8
DOIs
StatePublished - Aug 1 2015

Fingerprint

Cerebral Hemorrhage
Genetic Loci
Genetic Predisposition to Disease
Sample Size
Meta-Analysis
Chromosomes
Genome
Genes

Keywords

  • apolipoproteins E
  • cerebral hemorrhage
  • genome-wide association study

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Radmanesh, F., Falcone, G. J., Anderson, C. D., McWilliams, D., Devan, W. J., Brown, W. M., ... Rosand, J. (2015). Rare Coding Variation and Risk of Intracerebral Hemorrhage. Stroke, 46(8), 2299-2301. https://doi.org/10.1161/STROKEAHA.115.009838

Rare Coding Variation and Risk of Intracerebral Hemorrhage. / Radmanesh, Farid; Falcone, Guido J.; Anderson, Christopher D.; McWilliams, David; Devan, William J.; Brown, W. Mark; Battey, Thomas W K; Ayres, Alison M.; Raffeld, Miriam R.; Schwab, Kristin; Sun, Guangyun; Deka, Ranjan; Viswanathan, Anand; Goldstein, Joshua N.; Greenberg, Steven M.; Tirschwell, David L.; Silliman, Scott L.; Selim, Magdy; Meschia, James F; Brown, Devin L.; Worrall, Bradford B.; Langefeld, Carl D.; Woo, Daniel; Rosand, Jonathan.

In: Stroke, Vol. 46, No. 8, 01.08.2015, p. 2299-2301.

Research output: Contribution to journalArticle

Radmanesh, F, Falcone, GJ, Anderson, CD, McWilliams, D, Devan, WJ, Brown, WM, Battey, TWK, Ayres, AM, Raffeld, MR, Schwab, K, Sun, G, Deka, R, Viswanathan, A, Goldstein, JN, Greenberg, SM, Tirschwell, DL, Silliman, SL, Selim, M, Meschia, JF, Brown, DL, Worrall, BB, Langefeld, CD, Woo, D & Rosand, J 2015, 'Rare Coding Variation and Risk of Intracerebral Hemorrhage', Stroke, vol. 46, no. 8, pp. 2299-2301. https://doi.org/10.1161/STROKEAHA.115.009838
Radmanesh F, Falcone GJ, Anderson CD, McWilliams D, Devan WJ, Brown WM et al. Rare Coding Variation and Risk of Intracerebral Hemorrhage. Stroke. 2015 Aug 1;46(8):2299-2301. https://doi.org/10.1161/STROKEAHA.115.009838
Radmanesh, Farid ; Falcone, Guido J. ; Anderson, Christopher D. ; McWilliams, David ; Devan, William J. ; Brown, W. Mark ; Battey, Thomas W K ; Ayres, Alison M. ; Raffeld, Miriam R. ; Schwab, Kristin ; Sun, Guangyun ; Deka, Ranjan ; Viswanathan, Anand ; Goldstein, Joshua N. ; Greenberg, Steven M. ; Tirschwell, David L. ; Silliman, Scott L. ; Selim, Magdy ; Meschia, James F ; Brown, Devin L. ; Worrall, Bradford B. ; Langefeld, Carl D. ; Woo, Daniel ; Rosand, Jonathan. / Rare Coding Variation and Risk of Intracerebral Hemorrhage. In: Stroke. 2015 ; Vol. 46, No. 8. pp. 2299-2301.
@article{1d6eaeb97e3d4f12a5af0cb63cbaa64a,
title = "Rare Coding Variation and Risk of Intracerebral Hemorrhage",
abstract = "BACKGROUND AND PURPOSE: Intracerebral hemorrhage has a substantial genetic component. We performed a preliminary search for rare coding variants associated with intracerebral hemorrhage.METHODS: A total of 757 cases and 795 controls were genotyped using the Illumina HumanExome Beadchip (Illumina, Inc, San Diego, CA). Meta-analyses of single-variant and gene-based association were computed.RESULTS: No rare coding variants were associated with intracerebral hemorrhage. Three common variants on chromosome 19q13 at an established susceptibility locus, encompassing TOMM40, APOE, and APOC1, met genome-wide significance (PCONCLUSIONS: Although no coding variants of large effect were detected, this study further underscores a major challenge for the study of genetic susceptibility loci; large sample sizes are required for sufficient power except for loci with large effects.",
keywords = "apolipoproteins E, cerebral hemorrhage, genome-wide association study",
author = "Farid Radmanesh and Falcone, {Guido J.} and Anderson, {Christopher D.} and David McWilliams and Devan, {William J.} and Brown, {W. Mark} and Battey, {Thomas W K} and Ayres, {Alison M.} and Raffeld, {Miriam R.} and Kristin Schwab and Guangyun Sun and Ranjan Deka and Anand Viswanathan and Goldstein, {Joshua N.} and Greenberg, {Steven M.} and Tirschwell, {David L.} and Silliman, {Scott L.} and Magdy Selim and Meschia, {James F} and Brown, {Devin L.} and Worrall, {Bradford B.} and Langefeld, {Carl D.} and Daniel Woo and Jonathan Rosand",
year = "2015",
month = "8",
day = "1",
doi = "10.1161/STROKEAHA.115.009838",
language = "English (US)",
volume = "46",
pages = "2299--2301",
journal = "Stroke",
issn = "0039-2499",
publisher = "Lippincott Williams and Wilkins",
number = "8",

}

TY - JOUR

T1 - Rare Coding Variation and Risk of Intracerebral Hemorrhage

AU - Radmanesh, Farid

AU - Falcone, Guido J.

AU - Anderson, Christopher D.

AU - McWilliams, David

AU - Devan, William J.

AU - Brown, W. Mark

AU - Battey, Thomas W K

AU - Ayres, Alison M.

AU - Raffeld, Miriam R.

AU - Schwab, Kristin

AU - Sun, Guangyun

AU - Deka, Ranjan

AU - Viswanathan, Anand

AU - Goldstein, Joshua N.

AU - Greenberg, Steven M.

AU - Tirschwell, David L.

AU - Silliman, Scott L.

AU - Selim, Magdy

AU - Meschia, James F

AU - Brown, Devin L.

AU - Worrall, Bradford B.

AU - Langefeld, Carl D.

AU - Woo, Daniel

AU - Rosand, Jonathan

PY - 2015/8/1

Y1 - 2015/8/1

N2 - BACKGROUND AND PURPOSE: Intracerebral hemorrhage has a substantial genetic component. We performed a preliminary search for rare coding variants associated with intracerebral hemorrhage.METHODS: A total of 757 cases and 795 controls were genotyped using the Illumina HumanExome Beadchip (Illumina, Inc, San Diego, CA). Meta-analyses of single-variant and gene-based association were computed.RESULTS: No rare coding variants were associated with intracerebral hemorrhage. Three common variants on chromosome 19q13 at an established susceptibility locus, encompassing TOMM40, APOE, and APOC1, met genome-wide significance (PCONCLUSIONS: Although no coding variants of large effect were detected, this study further underscores a major challenge for the study of genetic susceptibility loci; large sample sizes are required for sufficient power except for loci with large effects.

AB - BACKGROUND AND PURPOSE: Intracerebral hemorrhage has a substantial genetic component. We performed a preliminary search for rare coding variants associated with intracerebral hemorrhage.METHODS: A total of 757 cases and 795 controls were genotyped using the Illumina HumanExome Beadchip (Illumina, Inc, San Diego, CA). Meta-analyses of single-variant and gene-based association were computed.RESULTS: No rare coding variants were associated with intracerebral hemorrhage. Three common variants on chromosome 19q13 at an established susceptibility locus, encompassing TOMM40, APOE, and APOC1, met genome-wide significance (PCONCLUSIONS: Although no coding variants of large effect were detected, this study further underscores a major challenge for the study of genetic susceptibility loci; large sample sizes are required for sufficient power except for loci with large effects.

KW - apolipoproteins E

KW - cerebral hemorrhage

KW - genome-wide association study

UR - http://www.scopus.com/inward/record.url?scp=84964697534&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84964697534&partnerID=8YFLogxK

U2 - 10.1161/STROKEAHA.115.009838

DO - 10.1161/STROKEAHA.115.009838

M3 - Article

C2 - 26111891

AN - SCOPUS:84964697534

VL - 46

SP - 2299

EP - 2301

JO - Stroke

JF - Stroke

SN - 0039-2499

IS - 8

ER -