Rapid rule-out of suspected acute coronary syndrome in the Emergency Department by high-sensitivity cardiac troponin T levels at presentation

Andrea Fabbri, Cristina Bachetti, Filippo Ottani, Alice Morelli, Barbara Benazzi, Sergio Spiezia, Marco Cortigiani, Romolo Dorizzi, Allan S Jaffe, Marcello Galvani

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The reliability of initial high-sensitivity cardiac troponin T (hs-cTnT) under limit-of-detection in ruling-out short- and long-term acute coronary events in subjects for suspected non-ST-segment elevation acute coronary syndrome (NSTE-ACS) is not definitely settled. In a retrospective chart review analysis, 1001 subjects with hs-cTnT ≤ 14 ng/L out of 4053 subjects with hs-cTnT measured at Emergency Department (ED) presentation were recruited. The main outcome measure is fatal or non-fatal myocardial infarction (MI) within 30 days; secondary outcomes are MI or major acute coronary events (MACE) as a combination of MI or re-hospitalization for unstable angina within 1 year. In subjects with hs-cTnT < 5 ng/L [32.6% of cases, mean age 63 years (interquartile range 23)], no cases (0%, NPV 100%) had MI within 30 days, 2 cases (0.6%, NPV 99.4%) MI at 1-year, and 11 cases (3.4%, NPV 96.6%) MACE at 1-year. Patients with hs-cTnT < 5 ng/L would have benefited from a shortened decision (9.30 h and 53% overnight ED stay saved). Hs-cTnT < 5 ng/L is confirmed as safe for patients and comfortable for physicians in ruling out MI or MACE both at short and long term, suggesting that a sizable number of patients can be rapidly discharged without unnecessary diagnostic tests and ED observation.

Original languageEnglish (US)
JournalInternal and Emergency Medicine
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Troponin T
Acute Coronary Syndrome
Hospital Emergency Service
Myocardial Infarction
Unstable Angina
Routine Diagnostic Tests
Limit of Detection
Hospitalization
Observation
Outcome Assessment (Health Care)
Physicians

Keywords

  • Emergency department
  • Myocardial infarction
  • Suspected non-ST-segment elevation acute coronary syndrome
  • Undetectable high-sensitivity cardiac troponin T

ASJC Scopus subject areas

  • Internal Medicine
  • Emergency Medicine

Cite this

Rapid rule-out of suspected acute coronary syndrome in the Emergency Department by high-sensitivity cardiac troponin T levels at presentation. / Fabbri, Andrea; Bachetti, Cristina; Ottani, Filippo; Morelli, Alice; Benazzi, Barbara; Spiezia, Sergio; Cortigiani, Marco; Dorizzi, Romolo; Jaffe, Allan S; Galvani, Marcello.

In: Internal and Emergency Medicine, 01.01.2018.

Research output: Contribution to journalArticle

Fabbri, Andrea ; Bachetti, Cristina ; Ottani, Filippo ; Morelli, Alice ; Benazzi, Barbara ; Spiezia, Sergio ; Cortigiani, Marco ; Dorizzi, Romolo ; Jaffe, Allan S ; Galvani, Marcello. / Rapid rule-out of suspected acute coronary syndrome in the Emergency Department by high-sensitivity cardiac troponin T levels at presentation. In: Internal and Emergency Medicine. 2018.
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abstract = "The reliability of initial high-sensitivity cardiac troponin T (hs-cTnT) under limit-of-detection in ruling-out short- and long-term acute coronary events in subjects for suspected non-ST-segment elevation acute coronary syndrome (NSTE-ACS) is not definitely settled. In a retrospective chart review analysis, 1001 subjects with hs-cTnT ≤ 14 ng/L out of 4053 subjects with hs-cTnT measured at Emergency Department (ED) presentation were recruited. The main outcome measure is fatal or non-fatal myocardial infarction (MI) within 30 days; secondary outcomes are MI or major acute coronary events (MACE) as a combination of MI or re-hospitalization for unstable angina within 1 year. In subjects with hs-cTnT < 5 ng/L [32.6{\%} of cases, mean age 63 years (interquartile range 23)], no cases (0{\%}, NPV 100{\%}) had MI within 30 days, 2 cases (0.6{\%}, NPV 99.4{\%}) MI at 1-year, and 11 cases (3.4{\%}, NPV 96.6{\%}) MACE at 1-year. Patients with hs-cTnT < 5 ng/L would have benefited from a shortened decision (9.30 h and 53{\%} overnight ED stay saved). Hs-cTnT < 5 ng/L is confirmed as safe for patients and comfortable for physicians in ruling out MI or MACE both at short and long term, suggesting that a sizable number of patients can be rapidly discharged without unnecessary diagnostic tests and ED observation.",
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AU - Morelli, Alice

AU - Benazzi, Barbara

AU - Spiezia, Sergio

AU - Cortigiani, Marco

AU - Dorizzi, Romolo

AU - Jaffe, Allan S

AU - Galvani, Marcello

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