TY - JOUR
T1 - Rapid quantitative assessment of myocardial perfusion
T2 - Spectral analysis of myocardial contrast echocardiographic images
AU - Bae, Richard Y.
AU - Belohlavek, Marek
AU - Greenleaf, James F.
AU - Seward, James B.
N1 - Funding Information:
Supported by the Mayo CR Program (R.Y.B.).
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2002/1
Y1 - 2002/1
N2 - We described a novel rapid spectral analysis technique performed on raw digital in-phase quadrature (IQ) data that quantitatively differentiated perfused from nonperfused myocardium based on the simultaneous comparison of local fundamental and harmonic frequency band intensity levels. In open-chest pigs after ligation of the left anterior descending coronary artery (LAD) and continuous venous contrast infusion, the fundamental-to-harmonic intensity ratio (FHIR) for samples placed within the left ventricular (LV) cavity (10.8 ± 1.7 dB) and perfused myocardium (13.7 ± 1.6 dB) were significantly (P < .001) lower than for nonperfused myocardium (27.1 ± 2.9 dB). In attenuated images, the FHIR for the LV cavity and perfused myocardium were also significantly (P < .05) lower than for the nonperfused myocardium (21.4 ± 3.0 dB, 34.4 ± 3.2 dB, and 40.2 ± 4.4 dB, respectively). Spectral properties of contrast microbubbles, as characterized by the FHIR, allow for rapid quantitative assessment of myocardial perfusion from data contained in a single-image frame, without requiring background image subtraction and image averaging.
AB - We described a novel rapid spectral analysis technique performed on raw digital in-phase quadrature (IQ) data that quantitatively differentiated perfused from nonperfused myocardium based on the simultaneous comparison of local fundamental and harmonic frequency band intensity levels. In open-chest pigs after ligation of the left anterior descending coronary artery (LAD) and continuous venous contrast infusion, the fundamental-to-harmonic intensity ratio (FHIR) for samples placed within the left ventricular (LV) cavity (10.8 ± 1.7 dB) and perfused myocardium (13.7 ± 1.6 dB) were significantly (P < .001) lower than for nonperfused myocardium (27.1 ± 2.9 dB). In attenuated images, the FHIR for the LV cavity and perfused myocardium were also significantly (P < .05) lower than for the nonperfused myocardium (21.4 ± 3.0 dB, 34.4 ± 3.2 dB, and 40.2 ± 4.4 dB, respectively). Spectral properties of contrast microbubbles, as characterized by the FHIR, allow for rapid quantitative assessment of myocardial perfusion from data contained in a single-image frame, without requiring background image subtraction and image averaging.
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U2 - 10.1067/mje.2002.115657
DO - 10.1067/mje.2002.115657
M3 - Article
C2 - 11781556
AN - SCOPUS:0036364583
SN - 0894-7317
VL - 15
SP - 63
EP - 68
JO - Journal of the American Society of Echocardiography
JF - Journal of the American Society of Echocardiography
IS - 1
ER -