Rapid progression of prostate cancer in men with a BRCA2 mutation

S. A. Narod; S. Neuhausen; G. Vichodez; S. Armel; H. T. Lynch; P. Ghadirian; S. Cummings; O. Olopade; D. Stoppa-Lyonnet; F. Couch; T. Wagner; E. Warner; W. D. Foulkes; H. Saal; J. Weitzel; A. Tulman; A. Poll; R. Nam; P. Sun; Jessica Danquah; Susan Domchek; Nadine Tung; Peter Ainsworth; Douglas Horsman; Charmaine Kim-Sing; Christine Maugard; Andrea Eisen; Mary Daly; Wendy McKinnon; Marie Wood; Claudine Isaacs; Dawna Gilchrist; Beth Karlan; Raluca Nedelcu; Wendy Meschino; Judy Garber; Barbara Pasini; Siranoush Manoukian; Christina Bellati

doi:10.1038/sj.bjc.6604453

Rapid progression of prostate cancer in men with a BRCA2 mutation

S. A. Narod, S. Neuhausen, G. Vichodez, S. Armel, H. T. Lynch, P. Ghadirian, S. Cummings, O. Olopade, D. Stoppa-Lyonnet, F. Couch, T. Wagner, E. Warner, W. D. Foulkes, H. Saal, J. Weitzel, A. Tulman, A. Poll, R. Nam, P. Sun, Jessica DanquahSusan Domchek, Nadine Tung, Peter Ainsworth, Douglas Horsman, Charmaine Kim-Sing, Christine Maugard, Andrea Eisen, Mary Daly, Wendy McKinnon, Marie Wood, Claudine Isaacs, Dawna Gilchrist, Beth Karlan, Raluca Nedelcu, Wendy Meschino, Judy Garber, Barbara Pasini, Siranoush Manoukian, Christina Bellati

Research output: Contribution to journal › Article › peer-review

108 Scopus citations

Abstract

Men with BRCA2 mutations have been found to be at increased risk of developing prostate cancer. There is a recent report that BRCA2 carriers with prostate cancer have poorer survival than noncarrier prostate cancer patients. In this study, we compared survival of men with a BRCA2 mutation and prostate cancer with that of men with a BRCA1 mutation and prostate cancer. We obtained the age at diagnosis, age at death or current age from 182 men with prostate cancer from families with a BRCA2 mutation and from 119 men with prostate cancer from families with a BRCA1 mutation. The median survival from diagnosis was 4.0 years for men with a BRCA2 mutation vs 8.0 years for men with a BRCA1 mutation, and the difference was highly significant (P<0.01). It may be important to develop targeted chemotherapies to treat prostate cancer in men with a BRCA2 mutation.

Original language	English (US)
Pages (from-to)	371-374
Number of pages	4
Journal	British journal of cancer
Volume	99
Issue number	2
DOIs	https://doi.org/10.1038/sj.bjc.6604453
State	Published - Jul 22 2008

Keywords

BRCA1
BRCA2
Prostate cancer

ASJC Scopus subject areas

Oncology
Cancer Research

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Narod, S. A., Neuhausen, S., Vichodez, G., Armel, S., Lynch, H. T., Ghadirian, P., Cummings, S., Olopade, O., Stoppa-Lyonnet, D., Couch, F., Wagner, T., Warner, E., Foulkes, W. D., Saal, H., Weitzel, J., Tulman, A., Poll, A., Nam, R., Sun, P., ... Bellati, C. (2008). Rapid progression of prostate cancer in men with a BRCA2 mutation. British journal of cancer, 99(2), 371-374. https://doi.org/10.1038/sj.bjc.6604453

Rapid progression of prostate cancer in men with a BRCA2 mutation. / Narod, S. A.; Neuhausen, S.; Vichodez, G.; Armel, S.; Lynch, H. T.; Ghadirian, P.; Cummings, S.; Olopade, O.; Stoppa-Lyonnet, D.; Couch, F.; Wagner, T.; Warner, E.; Foulkes, W. D.; Saal, H.; Weitzel, J.; Tulman, A.; Poll, A.; Nam, R.; Sun, P.; Danquah, Jessica; Domchek, Susan; Tung, Nadine; Ainsworth, Peter; Horsman, Douglas; Kim-Sing, Charmaine; Maugard, Christine; Eisen, Andrea; Daly, Mary; McKinnon, Wendy; Wood, Marie; Isaacs, Claudine; Gilchrist, Dawna; Karlan, Beth; Nedelcu, Raluca; Meschino, Wendy; Garber, Judy; Pasini, Barbara; Manoukian, Siranoush; Bellati, Christina.

In: British journal of cancer, Vol. 99, No. 2, 22.07.2008, p. 371-374.

Research output: Contribution to journal › Article › peer-review

Narod, SA, Neuhausen, S, Vichodez, G, Armel, S, Lynch, HT, Ghadirian, P, Cummings, S, Olopade, O, Stoppa-Lyonnet, D, Couch, F, Wagner, T, Warner, E, Foulkes, WD, Saal, H, Weitzel, J, Tulman, A, Poll, A, Nam, R, Sun, P, Danquah, J, Domchek, S, Tung, N, Ainsworth, P, Horsman, D, Kim-Sing, C, Maugard, C, Eisen, A, Daly, M, McKinnon, W, Wood, M, Isaacs, C, Gilchrist, D, Karlan, B, Nedelcu, R, Meschino, W, Garber, J, Pasini, B, Manoukian, S & Bellati, C 2008, 'Rapid progression of prostate cancer in men with a BRCA2 mutation', British journal of cancer, vol. 99, no. 2, pp. 371-374. https://doi.org/10.1038/sj.bjc.6604453

Narod, S. A. ; Neuhausen, S. ; Vichodez, G. ; Armel, S. ; Lynch, H. T. ; Ghadirian, P. ; Cummings, S. ; Olopade, O. ; Stoppa-Lyonnet, D. ; Couch, F. ; Wagner, T. ; Warner, E. ; Foulkes, W. D. ; Saal, H. ; Weitzel, J. ; Tulman, A. ; Poll, A. ; Nam, R. ; Sun, P. ; Danquah, Jessica ; Domchek, Susan ; Tung, Nadine ; Ainsworth, Peter ; Horsman, Douglas ; Kim-Sing, Charmaine ; Maugard, Christine ; Eisen, Andrea ; Daly, Mary ; McKinnon, Wendy ; Wood, Marie ; Isaacs, Claudine ; Gilchrist, Dawna ; Karlan, Beth ; Nedelcu, Raluca ; Meschino, Wendy ; Garber, Judy ; Pasini, Barbara ; Manoukian, Siranoush ; Bellati, Christina. / Rapid progression of prostate cancer in men with a BRCA2 mutation. In: British journal of cancer. 2008 ; Vol. 99, No. 2. pp. 371-374.

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abstract = "Men with BRCA2 mutations have been found to be at increased risk of developing prostate cancer. There is a recent report that BRCA2 carriers with prostate cancer have poorer survival than noncarrier prostate cancer patients. In this study, we compared survival of men with a BRCA2 mutation and prostate cancer with that of men with a BRCA1 mutation and prostate cancer. We obtained the age at diagnosis, age at death or current age from 182 men with prostate cancer from families with a BRCA2 mutation and from 119 men with prostate cancer from families with a BRCA1 mutation. The median survival from diagnosis was 4.0 years for men with a BRCA2 mutation vs 8.0 years for men with a BRCA1 mutation, and the difference was highly significant (P<0.01). It may be important to develop targeted chemotherapies to treat prostate cancer in men with a BRCA2 mutation.",

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AU - Karlan, Beth

AU - Nedelcu, Raluca

AU - Meschino, Wendy

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N2 - Men with BRCA2 mutations have been found to be at increased risk of developing prostate cancer. There is a recent report that BRCA2 carriers with prostate cancer have poorer survival than noncarrier prostate cancer patients. In this study, we compared survival of men with a BRCA2 mutation and prostate cancer with that of men with a BRCA1 mutation and prostate cancer. We obtained the age at diagnosis, age at death or current age from 182 men with prostate cancer from families with a BRCA2 mutation and from 119 men with prostate cancer from families with a BRCA1 mutation. The median survival from diagnosis was 4.0 years for men with a BRCA2 mutation vs 8.0 years for men with a BRCA1 mutation, and the difference was highly significant (P<0.01). It may be important to develop targeted chemotherapies to treat prostate cancer in men with a BRCA2 mutation.

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Rapid progression of prostate cancer in men with a BRCA2 mutation

Abstract

Keywords

ASJC Scopus subject areas

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