Rapid cycling bipolar affective disorder: Lack of relation to hypothyroidism

Robert M. Post, Keith G. Kramlinger, Russell T. Joffe, Peter P. Roy-Byrne, Ann Rosoff, Mark A Frye, Teresa Huggins

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Thyroid indices were measured after an extended period of medication- free evaluation averaging 6 weeks in 67 consecutively admitted patients with bipolar illness. Thyroid hormone levels - thyroxine (T4), free T4 and triiodothyronine (T3) - were not significantly different in the 31 rapid cyclers (≤ 4 affective episodes/year) than in 36 non-rapid cyclers. Analysis of covariance indicated a non-significant trend relation between higher T4 and a greater number of effective episodes in the year prior to admission and male gender when ago was covaried. Several previous reports, primarily in medicated subjects, have suggested a link between rapid cycling patients and decreased peripheral thyroid indices (low hormone levels and elevated TSH), but now the majority of studies do not support such a relation. Among those in the literature, this study includes patients studied for the longest time off medications and farther suggests that the commonly-cited relation between subclinical hypothyroidism and rapid cycling bipolar illness be reevaluated.

Original languageEnglish (US)
Pages (from-to)1-7
Number of pages7
JournalPsychiatry Research
Volume72
Issue number1
DOIs
StatePublished - Aug 29 1997
Externally publishedYes

Fingerprint

Hypothyroidism
Mood Disorders
Bipolar Disorder
Thyroid Gland
Triiodothyronine
Thyroxine
Thyroid Hormones
Hormones

Keywords

  • Affective disorder
  • Hypothyroidism
  • Lithium
  • Rapid cycling
  • Thyroxine
  • Triiodothyronine

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Psychology(all)

Cite this

Post, R. M., Kramlinger, K. G., Joffe, R. T., Roy-Byrne, P. P., Rosoff, A., Frye, M. A., & Huggins, T. (1997). Rapid cycling bipolar affective disorder: Lack of relation to hypothyroidism. Psychiatry Research, 72(1), 1-7. https://doi.org/10.1016/S0165-1781(97)00076-0

Rapid cycling bipolar affective disorder : Lack of relation to hypothyroidism. / Post, Robert M.; Kramlinger, Keith G.; Joffe, Russell T.; Roy-Byrne, Peter P.; Rosoff, Ann; Frye, Mark A; Huggins, Teresa.

In: Psychiatry Research, Vol. 72, No. 1, 29.08.1997, p. 1-7.

Research output: Contribution to journalArticle

Post, RM, Kramlinger, KG, Joffe, RT, Roy-Byrne, PP, Rosoff, A, Frye, MA & Huggins, T 1997, 'Rapid cycling bipolar affective disorder: Lack of relation to hypothyroidism', Psychiatry Research, vol. 72, no. 1, pp. 1-7. https://doi.org/10.1016/S0165-1781(97)00076-0
Post, Robert M. ; Kramlinger, Keith G. ; Joffe, Russell T. ; Roy-Byrne, Peter P. ; Rosoff, Ann ; Frye, Mark A ; Huggins, Teresa. / Rapid cycling bipolar affective disorder : Lack of relation to hypothyroidism. In: Psychiatry Research. 1997 ; Vol. 72, No. 1. pp. 1-7.
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