Rapamycin Inhibits Corneal Allograft Rejection and Neovascularization

Timothy Olsen, Nancy M. Benegas, Andrea C. Joplin, Tony Evangelista, Elizabeth A. Mindrup, Edward J. Holland

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Objective: To investigate the immunosuppresive effect of rapamycin in prolonging allograft survival in the rat model of orthotopic allogeneic penetrating keratoplasty. Design: Thirty inbred Lewis rats received corneal allografts from Brown Norway donors. Animals were divided into two rapamycin treatment groups and one allogeneic control group. Results: By the second week after surgery, all of the control animals had experienced allograft failure due to allograft rejection. However, allografts in seven of 10 animals in the low-dose treatment group and allografts in seven of nine animals in the high-dose treatment group remained clear. In addition, corneal neovascularization was markedly reduced in the treated animals. Conclusion: The systemic administration of rapamycin prolongs corneal allograft survival and significantly inhibits the neovascular component of rejection in the rat model of orthotopic allogeneic penetrating keratoplasty.

Original languageEnglish (US)
Pages (from-to)1471-1475
Number of pages5
JournalArchives of ophthalmology
Volume112
Issue number11
DOIs
StatePublished - Jan 1 1994
Externally publishedYes

Fingerprint

Sirolimus
Allografts
Penetrating Keratoplasty
Inbred Lew Rats
Corneal Neovascularization
Norway
Therapeutics
Control Groups

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Olsen, T., Benegas, N. M., Joplin, A. C., Evangelista, T., Mindrup, E. A., & Holland, E. J. (1994). Rapamycin Inhibits Corneal Allograft Rejection and Neovascularization. Archives of ophthalmology, 112(11), 1471-1475. https://doi.org/10.1001/archopht.1994.01090230085026

Rapamycin Inhibits Corneal Allograft Rejection and Neovascularization. / Olsen, Timothy; Benegas, Nancy M.; Joplin, Andrea C.; Evangelista, Tony; Mindrup, Elizabeth A.; Holland, Edward J.

In: Archives of ophthalmology, Vol. 112, No. 11, 01.01.1994, p. 1471-1475.

Research output: Contribution to journalArticle

Olsen, T, Benegas, NM, Joplin, AC, Evangelista, T, Mindrup, EA & Holland, EJ 1994, 'Rapamycin Inhibits Corneal Allograft Rejection and Neovascularization', Archives of ophthalmology, vol. 112, no. 11, pp. 1471-1475. https://doi.org/10.1001/archopht.1994.01090230085026
Olsen, Timothy ; Benegas, Nancy M. ; Joplin, Andrea C. ; Evangelista, Tony ; Mindrup, Elizabeth A. ; Holland, Edward J. / Rapamycin Inhibits Corneal Allograft Rejection and Neovascularization. In: Archives of ophthalmology. 1994 ; Vol. 112, No. 11. pp. 1471-1475.
@article{dd18cec0077945f69d1318cd36de9867,
title = "Rapamycin Inhibits Corneal Allograft Rejection and Neovascularization",
abstract = "Objective: To investigate the immunosuppresive effect of rapamycin in prolonging allograft survival in the rat model of orthotopic allogeneic penetrating keratoplasty. Design: Thirty inbred Lewis rats received corneal allografts from Brown Norway donors. Animals were divided into two rapamycin treatment groups and one allogeneic control group. Results: By the second week after surgery, all of the control animals had experienced allograft failure due to allograft rejection. However, allografts in seven of 10 animals in the low-dose treatment group and allografts in seven of nine animals in the high-dose treatment group remained clear. In addition, corneal neovascularization was markedly reduced in the treated animals. Conclusion: The systemic administration of rapamycin prolongs corneal allograft survival and significantly inhibits the neovascular component of rejection in the rat model of orthotopic allogeneic penetrating keratoplasty.",
author = "Timothy Olsen and Benegas, {Nancy M.} and Joplin, {Andrea C.} and Tony Evangelista and Mindrup, {Elizabeth A.} and Holland, {Edward J.}",
year = "1994",
month = "1",
day = "1",
doi = "10.1001/archopht.1994.01090230085026",
language = "English (US)",
volume = "112",
pages = "1471--1475",
journal = "JAMA Ophthalmology",
issn = "2168-6165",
publisher = "American Medical Association",
number = "11",

}

TY - JOUR

T1 - Rapamycin Inhibits Corneal Allograft Rejection and Neovascularization

AU - Olsen, Timothy

AU - Benegas, Nancy M.

AU - Joplin, Andrea C.

AU - Evangelista, Tony

AU - Mindrup, Elizabeth A.

AU - Holland, Edward J.

PY - 1994/1/1

Y1 - 1994/1/1

N2 - Objective: To investigate the immunosuppresive effect of rapamycin in prolonging allograft survival in the rat model of orthotopic allogeneic penetrating keratoplasty. Design: Thirty inbred Lewis rats received corneal allografts from Brown Norway donors. Animals were divided into two rapamycin treatment groups and one allogeneic control group. Results: By the second week after surgery, all of the control animals had experienced allograft failure due to allograft rejection. However, allografts in seven of 10 animals in the low-dose treatment group and allografts in seven of nine animals in the high-dose treatment group remained clear. In addition, corneal neovascularization was markedly reduced in the treated animals. Conclusion: The systemic administration of rapamycin prolongs corneal allograft survival and significantly inhibits the neovascular component of rejection in the rat model of orthotopic allogeneic penetrating keratoplasty.

AB - Objective: To investigate the immunosuppresive effect of rapamycin in prolonging allograft survival in the rat model of orthotopic allogeneic penetrating keratoplasty. Design: Thirty inbred Lewis rats received corneal allografts from Brown Norway donors. Animals were divided into two rapamycin treatment groups and one allogeneic control group. Results: By the second week after surgery, all of the control animals had experienced allograft failure due to allograft rejection. However, allografts in seven of 10 animals in the low-dose treatment group and allografts in seven of nine animals in the high-dose treatment group remained clear. In addition, corneal neovascularization was markedly reduced in the treated animals. Conclusion: The systemic administration of rapamycin prolongs corneal allograft survival and significantly inhibits the neovascular component of rejection in the rat model of orthotopic allogeneic penetrating keratoplasty.

UR - http://www.scopus.com/inward/record.url?scp=0028144044&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028144044&partnerID=8YFLogxK

U2 - 10.1001/archopht.1994.01090230085026

DO - 10.1001/archopht.1994.01090230085026

M3 - Article

C2 - 7980138

AN - SCOPUS:0028144044

VL - 112

SP - 1471

EP - 1475

JO - JAMA Ophthalmology

JF - JAMA Ophthalmology

SN - 2168-6165

IS - 11

ER -