Randomized trial of thoracic irradiation plus combination chemotherapy for unresectable adenocarcinoma and large cell carcinoma of the lung

Robert T. Eagan; Robert E. Lee; Stephen Frytak; Thomas R. Fleming; Edward T. Cregan; James N. Ingle; Larry K. Kvols

doi:10.1016/0360-3016(79)90678-3

Randomized trial of thoracic irradiation plus combination chemotherapy for unresectable adenocarcinoma and large cell carcinoma of the lung

Robert T. Eagan, Robert E. Lee, Stephen Frytak, Thomas R. Fleming, Edward T. Cregan, James N. Ingle, Larry K. Kvols

Medical Oncology

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Sixty-eight evaluable patients with unresectable adenocarcinoma and large cell carcinoma of the lung were treated on a prospective randomized trial comparing thoracic radiation therapy (TRT) plus combination chemotherapy with either cyclophosphamide, Adriamycin and cis-platinum (CAP) or cyclophosphamide, Adriamycin (same dosages) and DTIC (CAD), 34 on each arm. Patients treated with TRT plus CAP had a better overall regression rate (59% vs 47%) and a statistically significant superiority in time to disease progression (147 days vs 303 days) and survival (217 days vs 504 days).

Original language	English (US)
Pages (from-to)	1401-1405
Number of pages	5
Journal	International journal of radiation oncology, biology, physics
Volume	5
Issue number	8
DOIs	https://doi.org/10.1016/0360-3016(79)90678-3
State	Published - Aug 1979

Keywords

Chemotherapy
Combined modality therapy
Lung cancer
Radiation therapy

ASJC Scopus subject areas

Radiation
Oncology
Radiology Nuclear Medicine and imaging
Cancer Research

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10.1016/0360-3016(79)90678-3

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Eagan, R. T., Lee, R. E., Frytak, S., Fleming, T. R., Cregan, E. T., Ingle, J. N., & Kvols, L. K. (1979). Randomized trial of thoracic irradiation plus combination chemotherapy for unresectable adenocarcinoma and large cell carcinoma of the lung. International journal of radiation oncology, biology, physics, 5(8), 1401-1405. https://doi.org/10.1016/0360-3016(79)90678-3

Randomized trial of thoracic irradiation plus combination chemotherapy for unresectable adenocarcinoma and large cell carcinoma of the lung. / Eagan, Robert T.; Lee, Robert E.; Frytak, Stephen et al.
In: International journal of radiation oncology, biology, physics, Vol. 5, No. 8, 08.1979, p. 1401-1405.

Research output: Contribution to journal › Article › peer-review

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abstract = "Sixty-eight evaluable patients with unresectable adenocarcinoma and large cell carcinoma of the lung were treated on a prospective randomized trial comparing thoracic radiation therapy (TRT) plus combination chemotherapy with either cyclophosphamide, Adriamycin and cis-platinum (CAP) or cyclophosphamide, Adriamycin (same dosages) and DTIC (CAD), 34 on each arm. Patients treated with TRT plus CAP had a better overall regression rate (59% vs 47%) and a statistically significant superiority in time to disease progression (147 days vs 303 days) and survival (217 days vs 504 days).",

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AU - Cregan, Edward T.

AU - Ingle, James N.

AU - Kvols, Larry K.

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Randomized trial of thoracic irradiation plus combination chemotherapy for unresectable adenocarcinoma and large cell carcinoma of the lung

Abstract

Keywords

ASJC Scopus subject areas

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