Randomized trial of a chlorhexidine mouthwash for alleviation of radiation-induced mucositis

Robert L. Foote, Charles L. Loprinzi, Albert R. Frank, Judith R. O'Fallon, Sunil Gulavita, Hamed H. Tewfik, Martha A. Ryan, Julie M. Earle, Paul Novotny

Research output: Contribution to journalArticle

142 Scopus citations

Abstract

Purpose: To determine whether a chlorhexidine mouthwash could alleviate radiation-induced oral mucositis. Patients and Methods: Patients scheduled to receive radiation therapy to include greater than one third of the oral cavity mucosa were selected for study. Following stratification, they were randomized in a double-blind manner to receive a chlorhexidine mouthwash or a placebo mouthwash. Both groups were then similarly evaluated for mucositis and mouthwash toxicity. Results: Twenty-five patients were randomized to receive the chlorhexidine mouthwash, while 27 received the placebo mouthwash. Treatment arms were well balanced. There was a trend for more mucositis and there was substantially more toxicity (eg, mouthwash-induced discomfort, taste alteration, and teeth staining) on the chlorhexidine arm. Conclusion: In contrast to the prestudy hypothesis that a chlorhexidine mouthwash might provide benefit for patients receiving radiation therapy to the oral mucosa, this study provides strong evidence suggesting that a chlorhexidine mouthwash is detrimental in this clinical situation.

Original languageEnglish (US)
Pages (from-to)2630-2633
Number of pages4
JournalJournal of Clinical Oncology
Volume12
Issue number12
DOIs
StatePublished - Dec 1994

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Randomized trial of a chlorhexidine mouthwash for alleviation of radiation-induced mucositis'. Together they form a unique fingerprint.

  • Cite this

    Foote, R. L., Loprinzi, C. L., Frank, A. R., O'Fallon, J. R., Gulavita, S., Tewfik, H. H., Ryan, M. A., Earle, J. M., & Novotny, P. (1994). Randomized trial of a chlorhexidine mouthwash for alleviation of radiation-induced mucositis. Journal of Clinical Oncology, 12(12), 2630-2633. https://doi.org/10.1200/JCO.1994.12.12.2630