TY - JOUR
T1 - Randomized controlled trial of vertebroplasty versus kyphoplasty in the treatment of vertebral compression fractures
AU - Evans, Avery J.
AU - Kip, Kevin E.
AU - Brinjikji, Waleed
AU - Layton, Kennith F.
AU - Jensen, Mary L.
AU - Gaughen, John R.
AU - Kallmes, David F.
N1 - Publisher Copyright:
© 2016 Published by the BMJ Publishing Group Limited.
PY - 2016/7
Y1 - 2016/7
N2 - We present the results of a randomized controlled trial evaluating the efficacy of vertebroplasty versus kyphoplasty in treating vertebral body compression fractures. Methods Patients with vertebral body compression fractures were randomly assigned to treatment with kyphoplasty or vertebroplasty. Primary endpoints were pain (0-10 scale) and disability assessed using the Roland-Morris Disability Questionnaire (RMDQ). Outcomes were assessed at 3days, 1month, 6months, and 1year following the procedure. Results 115 subjects were enrolled in the trial with 59 (51.3%) randomly assigned to kyphoplasty and 56 (48.7%) assigned to vertebroplasty. Mean (SD) pain scores at baseline, 3days, 30days, and 1year for kyphoplasty versus vertebroplasty were 7.4 (1.9) vs 7.9 (2.0), 4.1 (2.8) vs 3.7 (3.0), 3.4 (2.5) vs 3.6 (2.9), and 3.0 (2.8) vs 2.3 (2.6), respectively (p > 0.05 at all time points). Mean (SD) RMDQ scores at baseline, 3days, 30days, 180days, and 1year were 17.3 (6.6) vs 16.3 (7.4), 11.8 (7.9) vs 10.9 (8.2), 8.6 (7.2) vs 8.8 (8.5), 7.9 (7.4) vs 7.3 (7.7), 7.5 (7.2) vs 6.7 (8.0), respectively (p>0.05 at all time points). For baseline to 12-month assessment in average pain and RMDQ scores, the standardized effect size between kyphoplasty and vertebroplasty was small at-0.36 (95% CI-1.02 to 0.31) and-0.04 (95% CI-1.68 to 1.60), respectively. Conclusions Our study indicates that vertebroplasty and kyphoplasty appear to be equally effective in substantially reducing pain and disability in patients with vertebral body compression fractures.
AB - We present the results of a randomized controlled trial evaluating the efficacy of vertebroplasty versus kyphoplasty in treating vertebral body compression fractures. Methods Patients with vertebral body compression fractures were randomly assigned to treatment with kyphoplasty or vertebroplasty. Primary endpoints were pain (0-10 scale) and disability assessed using the Roland-Morris Disability Questionnaire (RMDQ). Outcomes were assessed at 3days, 1month, 6months, and 1year following the procedure. Results 115 subjects were enrolled in the trial with 59 (51.3%) randomly assigned to kyphoplasty and 56 (48.7%) assigned to vertebroplasty. Mean (SD) pain scores at baseline, 3days, 30days, and 1year for kyphoplasty versus vertebroplasty were 7.4 (1.9) vs 7.9 (2.0), 4.1 (2.8) vs 3.7 (3.0), 3.4 (2.5) vs 3.6 (2.9), and 3.0 (2.8) vs 2.3 (2.6), respectively (p > 0.05 at all time points). Mean (SD) RMDQ scores at baseline, 3days, 30days, 180days, and 1year were 17.3 (6.6) vs 16.3 (7.4), 11.8 (7.9) vs 10.9 (8.2), 8.6 (7.2) vs 8.8 (8.5), 7.9 (7.4) vs 7.3 (7.7), 7.5 (7.2) vs 6.7 (8.0), respectively (p>0.05 at all time points). For baseline to 12-month assessment in average pain and RMDQ scores, the standardized effect size between kyphoplasty and vertebroplasty was small at-0.36 (95% CI-1.02 to 0.31) and-0.04 (95% CI-1.68 to 1.60), respectively. Conclusions Our study indicates that vertebroplasty and kyphoplasty appear to be equally effective in substantially reducing pain and disability in patients with vertebral body compression fractures.
KW - Balloon
KW - Spine
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U2 - 10.1136/neurintsurg-2015-011811
DO - 10.1136/neurintsurg-2015-011811
M3 - Article
C2 - 26109687
AN - SCOPUS:84977664124
SN - 1759-8478
VL - 8
SP - 756
EP - 763
JO - Journal of neurointerventional surgery
JF - Journal of neurointerventional surgery
IS - 7
ER -