Randomized controlled trial examining the adjunctive use of nicotine lozenges with MyLastDip: An eHealth smokeless tobacco cessation intervention

Brian G. Danaher, Herbert H. Severson, Ryann Crowley, Nora van Meter, Milagra S. Tyler, Chris Widdop, Edward Lichtenstein, Jon Owen Ebbert

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Introduction: Promising Web-based interventions for smokeless tobacco cessation have emerged. We describe a randomized controlled trial (RCT) testing the relative benefits of adding the nicotine lozenge as an adjunct to the MyLastDip Web-based smokeless tobacco cessation intervention. Methods: 407 smokeless tobacco users who wanted to quit were recruited, screened online, and randomly assigned to one of two conditions: (a) the interactive MyLastDip Web-based intervention (Web Only; n = 202), or (b) the website plus the offer of nicotine lozenges (Web. +. Lozenge; n = 205). MyLastDip program content is grouped according to three sequential frames: preparing to quit, quitting, and staying quit. If a participant reported a lapse then the program would provide tailored content on lessons learned and starting over ("retooling"). The primary outcome was 7-day point prevalence tobacco abstinence measured at follow-up assessments that occurred 3. months and 6. months post-enrollment. Results: Assessment completion rates were 71.5% at 3. months, 72.9% at 6. months, and 65.1% for both 3 and 6. months, and did not differ by condition. Using Intent to Treat analyses, the Web. +. Lozenge condition was associated with a significantly higher 7-day point prevalence tobacco abstinence rate than the Web Only condition at 3. months (43.4% vs. 29.7%, p = .004), at the combined 3 and 6. month assessment of repeated point prevalence (35.6% vs. 23.3%, p = .007), but not at 6. months (44.4% vs. 35.1%, p = .057). Similar results were obtained for smokeless tobacco abstinence. Participants reported being satisfied with their programs and the Web. +. Lozenge condition participants visited the MyLastDip program more often (p<. .001). A composite engagement measure of the number and duration of program visits was positively related to 6-month tobacco abstinence (p = .009). Conclusions: Consistent with previous research, the MyLastDip Web-based tobacco cessation intervention encouraged long-term levels of tobacco and smokeless tobacco abstinence. The addition of nicotine lozenges significantly improved both participant engagement and self-reported 7-day point prevalence tobacco abstinence at 3. months and when considering 3- and 6-month repeated point prevalence tobacco abstinence.

Original languageEnglish (US)
Pages (from-to)69-76
Number of pages8
JournalInternet Interventions
Volume2
Issue number1
DOIs
StatePublished - Mar 1 2015

Fingerprint

Tobacco Use Cessation
Tobacco Use Cessation Products
Telemedicine
Tobacco
Randomized Controlled Trials
Smokeless Tobacco
Research

Keywords

  • Abstinence
  • Cessation
  • EHealth
  • Internet
  • Intervention
  • Nicotine replacement
  • Smokeless tobacco
  • Web

ASJC Scopus subject areas

  • Health Informatics

Cite this

Randomized controlled trial examining the adjunctive use of nicotine lozenges with MyLastDip : An eHealth smokeless tobacco cessation intervention. / Danaher, Brian G.; Severson, Herbert H.; Crowley, Ryann; van Meter, Nora; Tyler, Milagra S.; Widdop, Chris; Lichtenstein, Edward; Ebbert, Jon Owen.

In: Internet Interventions, Vol. 2, No. 1, 01.03.2015, p. 69-76.

Research output: Contribution to journalArticle

Danaher, Brian G. ; Severson, Herbert H. ; Crowley, Ryann ; van Meter, Nora ; Tyler, Milagra S. ; Widdop, Chris ; Lichtenstein, Edward ; Ebbert, Jon Owen. / Randomized controlled trial examining the adjunctive use of nicotine lozenges with MyLastDip : An eHealth smokeless tobacco cessation intervention. In: Internet Interventions. 2015 ; Vol. 2, No. 1. pp. 69-76.
@article{3d30d609ad0e49019897301f3bb51366,
title = "Randomized controlled trial examining the adjunctive use of nicotine lozenges with MyLastDip: An eHealth smokeless tobacco cessation intervention",
abstract = "Introduction: Promising Web-based interventions for smokeless tobacco cessation have emerged. We describe a randomized controlled trial (RCT) testing the relative benefits of adding the nicotine lozenge as an adjunct to the MyLastDip Web-based smokeless tobacco cessation intervention. Methods: 407 smokeless tobacco users who wanted to quit were recruited, screened online, and randomly assigned to one of two conditions: (a) the interactive MyLastDip Web-based intervention (Web Only; n = 202), or (b) the website plus the offer of nicotine lozenges (Web. +. Lozenge; n = 205). MyLastDip program content is grouped according to three sequential frames: preparing to quit, quitting, and staying quit. If a participant reported a lapse then the program would provide tailored content on lessons learned and starting over ({"}retooling{"}). The primary outcome was 7-day point prevalence tobacco abstinence measured at follow-up assessments that occurred 3. months and 6. months post-enrollment. Results: Assessment completion rates were 71.5{\%} at 3. months, 72.9{\%} at 6. months, and 65.1{\%} for both 3 and 6. months, and did not differ by condition. Using Intent to Treat analyses, the Web. +. Lozenge condition was associated with a significantly higher 7-day point prevalence tobacco abstinence rate than the Web Only condition at 3. months (43.4{\%} vs. 29.7{\%}, p = .004), at the combined 3 and 6. month assessment of repeated point prevalence (35.6{\%} vs. 23.3{\%}, p = .007), but not at 6. months (44.4{\%} vs. 35.1{\%}, p = .057). Similar results were obtained for smokeless tobacco abstinence. Participants reported being satisfied with their programs and the Web. +. Lozenge condition participants visited the MyLastDip program more often (p<. .001). A composite engagement measure of the number and duration of program visits was positively related to 6-month tobacco abstinence (p = .009). Conclusions: Consistent with previous research, the MyLastDip Web-based tobacco cessation intervention encouraged long-term levels of tobacco and smokeless tobacco abstinence. The addition of nicotine lozenges significantly improved both participant engagement and self-reported 7-day point prevalence tobacco abstinence at 3. months and when considering 3- and 6-month repeated point prevalence tobacco abstinence.",
keywords = "Abstinence, Cessation, EHealth, Internet, Intervention, Nicotine replacement, Smokeless tobacco, Web",
author = "Danaher, {Brian G.} and Severson, {Herbert H.} and Ryann Crowley and {van Meter}, Nora and Tyler, {Milagra S.} and Chris Widdop and Edward Lichtenstein and Ebbert, {Jon Owen}",
year = "2015",
month = "3",
day = "1",
doi = "10.1016/j.invent.2014.12.004",
language = "English (US)",
volume = "2",
pages = "69--76",
journal = "Internet Interventions",
issn = "2214-7829",
publisher = "Elsevier BV",
number = "1",

}

TY - JOUR

T1 - Randomized controlled trial examining the adjunctive use of nicotine lozenges with MyLastDip

T2 - An eHealth smokeless tobacco cessation intervention

AU - Danaher, Brian G.

AU - Severson, Herbert H.

AU - Crowley, Ryann

AU - van Meter, Nora

AU - Tyler, Milagra S.

AU - Widdop, Chris

AU - Lichtenstein, Edward

AU - Ebbert, Jon Owen

PY - 2015/3/1

Y1 - 2015/3/1

N2 - Introduction: Promising Web-based interventions for smokeless tobacco cessation have emerged. We describe a randomized controlled trial (RCT) testing the relative benefits of adding the nicotine lozenge as an adjunct to the MyLastDip Web-based smokeless tobacco cessation intervention. Methods: 407 smokeless tobacco users who wanted to quit were recruited, screened online, and randomly assigned to one of two conditions: (a) the interactive MyLastDip Web-based intervention (Web Only; n = 202), or (b) the website plus the offer of nicotine lozenges (Web. +. Lozenge; n = 205). MyLastDip program content is grouped according to three sequential frames: preparing to quit, quitting, and staying quit. If a participant reported a lapse then the program would provide tailored content on lessons learned and starting over ("retooling"). The primary outcome was 7-day point prevalence tobacco abstinence measured at follow-up assessments that occurred 3. months and 6. months post-enrollment. Results: Assessment completion rates were 71.5% at 3. months, 72.9% at 6. months, and 65.1% for both 3 and 6. months, and did not differ by condition. Using Intent to Treat analyses, the Web. +. Lozenge condition was associated with a significantly higher 7-day point prevalence tobacco abstinence rate than the Web Only condition at 3. months (43.4% vs. 29.7%, p = .004), at the combined 3 and 6. month assessment of repeated point prevalence (35.6% vs. 23.3%, p = .007), but not at 6. months (44.4% vs. 35.1%, p = .057). Similar results were obtained for smokeless tobacco abstinence. Participants reported being satisfied with their programs and the Web. +. Lozenge condition participants visited the MyLastDip program more often (p<. .001). A composite engagement measure of the number and duration of program visits was positively related to 6-month tobacco abstinence (p = .009). Conclusions: Consistent with previous research, the MyLastDip Web-based tobacco cessation intervention encouraged long-term levels of tobacco and smokeless tobacco abstinence. The addition of nicotine lozenges significantly improved both participant engagement and self-reported 7-day point prevalence tobacco abstinence at 3. months and when considering 3- and 6-month repeated point prevalence tobacco abstinence.

AB - Introduction: Promising Web-based interventions for smokeless tobacco cessation have emerged. We describe a randomized controlled trial (RCT) testing the relative benefits of adding the nicotine lozenge as an adjunct to the MyLastDip Web-based smokeless tobacco cessation intervention. Methods: 407 smokeless tobacco users who wanted to quit were recruited, screened online, and randomly assigned to one of two conditions: (a) the interactive MyLastDip Web-based intervention (Web Only; n = 202), or (b) the website plus the offer of nicotine lozenges (Web. +. Lozenge; n = 205). MyLastDip program content is grouped according to three sequential frames: preparing to quit, quitting, and staying quit. If a participant reported a lapse then the program would provide tailored content on lessons learned and starting over ("retooling"). The primary outcome was 7-day point prevalence tobacco abstinence measured at follow-up assessments that occurred 3. months and 6. months post-enrollment. Results: Assessment completion rates were 71.5% at 3. months, 72.9% at 6. months, and 65.1% for both 3 and 6. months, and did not differ by condition. Using Intent to Treat analyses, the Web. +. Lozenge condition was associated with a significantly higher 7-day point prevalence tobacco abstinence rate than the Web Only condition at 3. months (43.4% vs. 29.7%, p = .004), at the combined 3 and 6. month assessment of repeated point prevalence (35.6% vs. 23.3%, p = .007), but not at 6. months (44.4% vs. 35.1%, p = .057). Similar results were obtained for smokeless tobacco abstinence. Participants reported being satisfied with their programs and the Web. +. Lozenge condition participants visited the MyLastDip program more often (p<. .001). A composite engagement measure of the number and duration of program visits was positively related to 6-month tobacco abstinence (p = .009). Conclusions: Consistent with previous research, the MyLastDip Web-based tobacco cessation intervention encouraged long-term levels of tobacco and smokeless tobacco abstinence. The addition of nicotine lozenges significantly improved both participant engagement and self-reported 7-day point prevalence tobacco abstinence at 3. months and when considering 3- and 6-month repeated point prevalence tobacco abstinence.

KW - Abstinence

KW - Cessation

KW - EHealth

KW - Internet

KW - Intervention

KW - Nicotine replacement

KW - Smokeless tobacco

KW - Web

UR - http://www.scopus.com/inward/record.url?scp=84920648538&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84920648538&partnerID=8YFLogxK

U2 - 10.1016/j.invent.2014.12.004

DO - 10.1016/j.invent.2014.12.004

M3 - Article

AN - SCOPUS:84920648538

VL - 2

SP - 69

EP - 76

JO - Internet Interventions

JF - Internet Interventions

SN - 2214-7829

IS - 1

ER -