Abstract
Fifty-five women with progressive metastatic breast cancer who were paramenopausal (1 to <5 years since last menstrual period) or castrated were randomized to receive either megestrol acetate (150 mg/m2 daily in three divided doses) or tamoxifen (10 mg twice daily). The regression rate (complete plus partial) was higher for tamoxifen (26%) than for megestrol acetate (14%), but not significantly so. Analysis of time to treatment failure showed no significant difference (medians: megestrol acetate, 65 days; tamoxifen, 58 days). There was a survival advantage associated with megestrol acetate (P = 0.02 after adjustment for stratification factors) that is difficult to interpret given the results of analysis of regression and time to treatment failure for the two agents.
Original language | English (US) |
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Pages (from-to) | 155-160 |
Number of pages | 6 |
Journal | Unknown Journal |
Volume | 5 |
Issue number | 2 |
DOIs | |
State | Published - 1982 |
ASJC Scopus subject areas
- Oncology
- Cancer Research