TY - JOUR
T1 - Raltitrexed (Tomudex®)
T2 - An alternative choice in patients intolerant to 5-fluorouracil
AU - Kempin, Sanford
AU - Gutierrez, Jorge
AU - Wilson, Elizabeth
AU - Lowery, Colin
AU - Diasio, Robert
PY - 2002
Y1 - 2002
N2 - Raltitrexed (Tomudex®), a classical folate antagonist, is a selective inhibitor of thymidylate synthase (TS). It has significant single-agent activity in metastatic colorectal cancer. Severe life-threatening toxicity related to the administration of 5-fluorouracil and leucovorin is described in two patients, both of whom were not deficient in dihydropyrimidine dehydrogenase. Raltitrexed was administered to both patients with clinically acceptable side effects and allowed a TS inhibitor to be administered as part of an adjuvant program.
AB - Raltitrexed (Tomudex®), a classical folate antagonist, is a selective inhibitor of thymidylate synthase (TS). It has significant single-agent activity in metastatic colorectal cancer. Severe life-threatening toxicity related to the administration of 5-fluorouracil and leucovorin is described in two patients, both of whom were not deficient in dihydropyrimidine dehydrogenase. Raltitrexed was administered to both patients with clinically acceptable side effects and allowed a TS inhibitor to be administered as part of an adjuvant program.
KW - An alternative
KW - Intolerance to 5-fluorouracil
KW - Raltitrexed (Tomudex®)
UR - http://www.scopus.com/inward/record.url?scp=0035986787&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035986787&partnerID=8YFLogxK
U2 - 10.1081/CNV-120005915
DO - 10.1081/CNV-120005915
M3 - Article
C2 - 12449732
AN - SCOPUS:0035986787
SN - 0735-7907
VL - 20
SP - 992
EP - 995
JO - Cancer Investigation
JF - Cancer Investigation
IS - 7-8
ER -