Radiosurgery with a rotating gamma system: A very effective treatment for symptomatic cerebral cavernomas

Pham Cam Phuong, Nguyen Duc Luan, Vo Thi Huyen Trang, Steven E. Schild, Dirk Rades, Mai Trong Khoa

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Aim: To evaluate the value of radiosurgery with a rotating gamma-system (RGS) for cerebral cavernomaS. Patients and Methods: Seventy-nine patients with symptomatic cerebral cavernomas underwent RGS radiosurgery at the Bach Mai Hospital, Hanoi, Vietnam. Median dose (single fraction) was 20 Gy (range=14-26 Gy). Endpoints included effect on headache, seizures and tumor size. Results: Of 60 patients with headache, 17% had complete response, 82% partial response and 2% stable disease (best response). Of 39 patients with seizures, 31% had complete response, 64% partial response and 5% stable disease. Four patients developed recurrent seizures after 1 year. Regarding the size of cavernoma at 15 months, complete response was observed in 6%, partial response in 75%, stable disease in 15%, progression in 1% and pseudo-progression in 3% of patientS. Bleeding within 2 years after RGS radiosurgery occurred in only five patients (6%). RGS dose had no significant impact on outcomeS. Conclusion: RGS radiosurgery provided very high rates of symptom relief in patients with cerebral cavernomaS.

Original languageEnglish (US)
Pages (from-to)3729-3733
Number of pages5
JournalAnticancer research
Volume37
Issue number7
DOIs
StatePublished - Jul 2017

Keywords

  • Cavernous angioma
  • Cavernous hemangioma
  • Cerebral cavernoma
  • Headache
  • Radiosurgery
  • Rotating-Gamma System
  • Seizures
  • Symptom relief

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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