TY - JOUR
T1 - Radiologic Findings Are Strongly Associated with a Pathologic Diagnosis of Usual Interstitial Pneumonia
AU - Hunninghake, Gary W.
AU - Lynch, David A.
AU - Galvin, Jeffrey R.
AU - Gross, Barry H.
AU - Müller, Nestor
AU - Schwartz, David A.
AU - King, Talmadge E.
AU - Lynch, Joseph P.
AU - Hegele, Richard
AU - Waldron, James
AU - Colby, Thomas V.
AU - Hogg, James C.
N1 - Funding Information:
This study was supported in part by the National Heart, Lung, and Blood Institute Specialized Centers of Research Program on ILD.
PY - 2003/10
Y1 - 2003/10
N2 - Purpose: To determine which clinical and radiologic findings are independently associated with a pathologic diagnosis of usual interstitial pneumonia (UIP). Methods: We recently reported, using a prospective, multicenter study of patients suspected of having idiopathic interstitial pneumonia (IIP), that a confident diagnosis of UIP made by experienced radiologists was correct in 95% of cases. In the current article, we further analyzed data from this study. Ninety-one patients were entered into the study. Clinical, physiologic, chest radiographic, and CT features were prospectively recorded, and analyzed using univariate and multivariate logistic regression analysis to compare the patients with a histologic diagnosis of UIP with those who received other pathologic diagnoses. Results: Fifty-four of 91 patients (59%) received a pathologic diagnosis of UIP. The following features recorded at the referring clinical centers were associated with a pathologic diagnosis of UIP on multivariate analysis: lower-lobe honeycombing on high-resolution CT (HRCT) [odds ratio, 11.45], radiographic findings consistent with UIP (odds ratio, 5.73), elevated ratio of FEV1 to FVC (odds ratio, 4.8), and absence of smoking history (odds ratio, 0.19). On multivariate analysis of specific HRCT features recorded by four experienced chest radiologists, lower-lung honeycombing (odds ratio, 5.36) and upper-lung irregular lines (odds ratio, 6.28) were the only independent predictors of UIP. Using only these two factors, a diagnosis of UIP could be established with a sensitivity of 74%, a specificity of 81%; and a positive predictive value of 85%. Conclusion: In patients presenting with a clinical syndrome suggestive of IIP, CT findings of lower-lung honeycombing and upper-lung irregular lines are most closely associated with a pathologic diagnosis of UIP.
AB - Purpose: To determine which clinical and radiologic findings are independently associated with a pathologic diagnosis of usual interstitial pneumonia (UIP). Methods: We recently reported, using a prospective, multicenter study of patients suspected of having idiopathic interstitial pneumonia (IIP), that a confident diagnosis of UIP made by experienced radiologists was correct in 95% of cases. In the current article, we further analyzed data from this study. Ninety-one patients were entered into the study. Clinical, physiologic, chest radiographic, and CT features were prospectively recorded, and analyzed using univariate and multivariate logistic regression analysis to compare the patients with a histologic diagnosis of UIP with those who received other pathologic diagnoses. Results: Fifty-four of 91 patients (59%) received a pathologic diagnosis of UIP. The following features recorded at the referring clinical centers were associated with a pathologic diagnosis of UIP on multivariate analysis: lower-lobe honeycombing on high-resolution CT (HRCT) [odds ratio, 11.45], radiographic findings consistent with UIP (odds ratio, 5.73), elevated ratio of FEV1 to FVC (odds ratio, 4.8), and absence of smoking history (odds ratio, 0.19). On multivariate analysis of specific HRCT features recorded by four experienced chest radiologists, lower-lung honeycombing (odds ratio, 5.36) and upper-lung irregular lines (odds ratio, 6.28) were the only independent predictors of UIP. Using only these two factors, a diagnosis of UIP could be established with a sensitivity of 74%, a specificity of 81%; and a positive predictive value of 85%. Conclusion: In patients presenting with a clinical syndrome suggestive of IIP, CT findings of lower-lung honeycombing and upper-lung irregular lines are most closely associated with a pathologic diagnosis of UIP.
KW - Chest radiograph
KW - Idiopathic interstitial pneumonia
KW - Idiopathic pulmonary fibrosis
KW - Interstitial lung disease
KW - Lung
KW - Lung CT scans
KW - Thorax
KW - Usual interstitial pneumonia
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U2 - 10.1378/chest.124.4.1215
DO - 10.1378/chest.124.4.1215
M3 - Article
C2 - 14555549
AN - SCOPUS:10744220627
SN - 0012-3692
VL - 124
SP - 1215
EP - 1223
JO - Chest
JF - Chest
IS - 4
ER -