Radioimmunoassay of somatostatin and its application in the study of pancreatic somatostatin secretion in vitro

J. Gerich, K. Greene, M. Hara, R. Rizza, G. Patton

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

A sensitive and specific radioimmunoassay for somatostatin is described. With the use of this system, somatostatin release from incubated rat pancreatic islets and perfused rat pancreases has been studied in vitro. Both arginine and glucose, known modulators of insulin and glucagon secretion, were found to stimulate somatostatin release. These results provide additional support for the concept that somatostatin may act as a local regulator of pancreatic A cell function.

Original languageEnglish (US)
Pages (from-to)1009-1017
Number of pages9
JournalThe Journal of Laboratory and Clinical Medicine
Volume93
Issue number6
StatePublished - 1979

Fingerprint

Somatostatin
Radioimmunoassay
Rats
Glucagon-Secreting Cells
Glucagon
Islets of Langerhans
Modulators
Arginine
Pancreas
Insulin
Glucose
In Vitro Techniques

ASJC Scopus subject areas

  • Medicine(all)
  • Pathology and Forensic Medicine

Cite this

Radioimmunoassay of somatostatin and its application in the study of pancreatic somatostatin secretion in vitro. / Gerich, J.; Greene, K.; Hara, M.; Rizza, R.; Patton, G.

In: The Journal of Laboratory and Clinical Medicine, Vol. 93, No. 6, 1979, p. 1009-1017.

Research output: Contribution to journalArticle

Gerich, J. ; Greene, K. ; Hara, M. ; Rizza, R. ; Patton, G. / Radioimmunoassay of somatostatin and its application in the study of pancreatic somatostatin secretion in vitro. In: The Journal of Laboratory and Clinical Medicine. 1979 ; Vol. 93, No. 6. pp. 1009-1017.
@article{9b10ad2c4a864e0797b889ad021c0467,
title = "Radioimmunoassay of somatostatin and its application in the study of pancreatic somatostatin secretion in vitro",
abstract = "A sensitive and specific radioimmunoassay for somatostatin is described. With the use of this system, somatostatin release from incubated rat pancreatic islets and perfused rat pancreases has been studied in vitro. Both arginine and glucose, known modulators of insulin and glucagon secretion, were found to stimulate somatostatin release. These results provide additional support for the concept that somatostatin may act as a local regulator of pancreatic A cell function.",
author = "J. Gerich and K. Greene and M. Hara and R. Rizza and G. Patton",
year = "1979",
language = "English (US)",
volume = "93",
pages = "1009--1017",
journal = "Translational Research",
issn = "1931-5244",
publisher = "Mosby Inc.",
number = "6",

}

TY - JOUR

T1 - Radioimmunoassay of somatostatin and its application in the study of pancreatic somatostatin secretion in vitro

AU - Gerich, J.

AU - Greene, K.

AU - Hara, M.

AU - Rizza, R.

AU - Patton, G.

PY - 1979

Y1 - 1979

N2 - A sensitive and specific radioimmunoassay for somatostatin is described. With the use of this system, somatostatin release from incubated rat pancreatic islets and perfused rat pancreases has been studied in vitro. Both arginine and glucose, known modulators of insulin and glucagon secretion, were found to stimulate somatostatin release. These results provide additional support for the concept that somatostatin may act as a local regulator of pancreatic A cell function.

AB - A sensitive and specific radioimmunoassay for somatostatin is described. With the use of this system, somatostatin release from incubated rat pancreatic islets and perfused rat pancreases has been studied in vitro. Both arginine and glucose, known modulators of insulin and glucagon secretion, were found to stimulate somatostatin release. These results provide additional support for the concept that somatostatin may act as a local regulator of pancreatic A cell function.

UR - http://www.scopus.com/inward/record.url?scp=0018730125&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018730125&partnerID=8YFLogxK

M3 - Article

VL - 93

SP - 1009

EP - 1017

JO - Translational Research

JF - Translational Research

SN - 1931-5244

IS - 6

ER -