Radiography, 99mTc-HDP, and 111in labeled vitamin B 12 SPECT of canine osteosarcoma: A comparative study

Robert Cruz, Phillip Steyn, Douglas Collins, Barbara Powers, John Urigh

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The objective of this article was to compare radiography, planar bone scintigraphy, and single-photon emission computed tomography (SPECT) to determine the size of osteosarcomas in long bones of dogs. Ten dogs with osteosarcoma in six radii, two humeri, one tibia, and one ulna were evaluated. Macroslides, mediolateral radiographs, planar scintigrams, and sagittal images from SPECT scans were used to obtain measurements. On the scintigraphic images, the edges of the tumor were established using the activity profile imaging tool. The radiographic magnification was factored. The mean percentage of tumor size overestimation was 9.29% on mediolateral radiographs, 5.35% on planar scintigrams, and 33.25% on SPECT images. The correlation coefficient adjusted for sample size was significantly higher (P<0.01) for technetium 99m ( 99mTc) hydroxyethylene diphosphonate (HDP) (75.5%) and radiography (61.3%) compared with indium 111-vitamin B 12 (28.3%). The correlation coefficient for 99mTc-HDP was higher than that obtained for radiographs; however, statistical difference between the two variables was not demonstrated (P>0.05). 99mTc bone scan is a good estimator of intramedullary size of osteosarcoma in long bones when the activity profile tool to determine the margin of the tumor is used.

Original languageEnglish (US)
Pages (from-to)229-235
Number of pages7
JournalJournal of the American Animal Hospital Association
Volume47
Issue number4
DOIs
StatePublished - Jul 2011

Fingerprint

osteosarcoma
Osteosarcoma
vitamin B12
Vitamin B 12
Single-Photon Emission-Computed Tomography
radiography
computed tomography
Radiography
scintigraphy
Canidae
bones
Bone and Bones
dogs
neoplasms
Radiographic Magnification
Dogs
Neoplasms
Ulna
ulna
radius (bone)

ASJC Scopus subject areas

  • Small Animals

Cite this

Radiography, 99mTc-HDP, and 111in labeled vitamin B 12 SPECT of canine osteosarcoma : A comparative study. / Cruz, Robert; Steyn, Phillip; Collins, Douglas; Powers, Barbara; Urigh, John.

In: Journal of the American Animal Hospital Association, Vol. 47, No. 4, 07.2011, p. 229-235.

Research output: Contribution to journalArticle

Cruz, Robert ; Steyn, Phillip ; Collins, Douglas ; Powers, Barbara ; Urigh, John. / Radiography, 99mTc-HDP, and 111in labeled vitamin B 12 SPECT of canine osteosarcoma : A comparative study. In: Journal of the American Animal Hospital Association. 2011 ; Vol. 47, No. 4. pp. 229-235.
@article{d3d32d3bec104492a1743f432685c73c,
title = "Radiography, 99mTc-HDP, and 111in labeled vitamin B 12 SPECT of canine osteosarcoma: A comparative study",
abstract = "The objective of this article was to compare radiography, planar bone scintigraphy, and single-photon emission computed tomography (SPECT) to determine the size of osteosarcomas in long bones of dogs. Ten dogs with osteosarcoma in six radii, two humeri, one tibia, and one ulna were evaluated. Macroslides, mediolateral radiographs, planar scintigrams, and sagittal images from SPECT scans were used to obtain measurements. On the scintigraphic images, the edges of the tumor were established using the activity profile imaging tool. The radiographic magnification was factored. The mean percentage of tumor size overestimation was 9.29{\%} on mediolateral radiographs, 5.35{\%} on planar scintigrams, and 33.25{\%} on SPECT images. The correlation coefficient adjusted for sample size was significantly higher (P<0.01) for technetium 99m ( 99mTc) hydroxyethylene diphosphonate (HDP) (75.5{\%}) and radiography (61.3{\%}) compared with indium 111-vitamin B 12 (28.3{\%}). The correlation coefficient for 99mTc-HDP was higher than that obtained for radiographs; however, statistical difference between the two variables was not demonstrated (P>0.05). 99mTc bone scan is a good estimator of intramedullary size of osteosarcoma in long bones when the activity profile tool to determine the margin of the tumor is used.",
author = "Robert Cruz and Phillip Steyn and Douglas Collins and Barbara Powers and John Urigh",
year = "2011",
month = "7",
doi = "10.5326/JAAHA-MS-5600",
language = "English (US)",
volume = "47",
pages = "229--235",
journal = "Journal of the American Animal Hospital Association",
issn = "0587-2871",
publisher = "American Animal Hospital Association",
number = "4",

}

TY - JOUR

T1 - Radiography, 99mTc-HDP, and 111in labeled vitamin B 12 SPECT of canine osteosarcoma

T2 - A comparative study

AU - Cruz, Robert

AU - Steyn, Phillip

AU - Collins, Douglas

AU - Powers, Barbara

AU - Urigh, John

PY - 2011/7

Y1 - 2011/7

N2 - The objective of this article was to compare radiography, planar bone scintigraphy, and single-photon emission computed tomography (SPECT) to determine the size of osteosarcomas in long bones of dogs. Ten dogs with osteosarcoma in six radii, two humeri, one tibia, and one ulna were evaluated. Macroslides, mediolateral radiographs, planar scintigrams, and sagittal images from SPECT scans were used to obtain measurements. On the scintigraphic images, the edges of the tumor were established using the activity profile imaging tool. The radiographic magnification was factored. The mean percentage of tumor size overestimation was 9.29% on mediolateral radiographs, 5.35% on planar scintigrams, and 33.25% on SPECT images. The correlation coefficient adjusted for sample size was significantly higher (P<0.01) for technetium 99m ( 99mTc) hydroxyethylene diphosphonate (HDP) (75.5%) and radiography (61.3%) compared with indium 111-vitamin B 12 (28.3%). The correlation coefficient for 99mTc-HDP was higher than that obtained for radiographs; however, statistical difference between the two variables was not demonstrated (P>0.05). 99mTc bone scan is a good estimator of intramedullary size of osteosarcoma in long bones when the activity profile tool to determine the margin of the tumor is used.

AB - The objective of this article was to compare radiography, planar bone scintigraphy, and single-photon emission computed tomography (SPECT) to determine the size of osteosarcomas in long bones of dogs. Ten dogs with osteosarcoma in six radii, two humeri, one tibia, and one ulna were evaluated. Macroslides, mediolateral radiographs, planar scintigrams, and sagittal images from SPECT scans were used to obtain measurements. On the scintigraphic images, the edges of the tumor were established using the activity profile imaging tool. The radiographic magnification was factored. The mean percentage of tumor size overestimation was 9.29% on mediolateral radiographs, 5.35% on planar scintigrams, and 33.25% on SPECT images. The correlation coefficient adjusted for sample size was significantly higher (P<0.01) for technetium 99m ( 99mTc) hydroxyethylene diphosphonate (HDP) (75.5%) and radiography (61.3%) compared with indium 111-vitamin B 12 (28.3%). The correlation coefficient for 99mTc-HDP was higher than that obtained for radiographs; however, statistical difference between the two variables was not demonstrated (P>0.05). 99mTc bone scan is a good estimator of intramedullary size of osteosarcoma in long bones when the activity profile tool to determine the margin of the tumor is used.

UR - http://www.scopus.com/inward/record.url?scp=79960511780&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79960511780&partnerID=8YFLogxK

U2 - 10.5326/JAAHA-MS-5600

DO - 10.5326/JAAHA-MS-5600

M3 - Article

C2 - 21673339

AN - SCOPUS:79960511780

VL - 47

SP - 229

EP - 235

JO - Journal of the American Animal Hospital Association

JF - Journal of the American Animal Hospital Association

SN - 0587-2871

IS - 4

ER -