Radioactive seed localization of nonpalpable breast lesions is better than wire localization

Richard J. Gray, Barbara A. Pockaj, Patricia J. Karstaedt, Michael C. Roarke

Research output: Contribution to journalArticlepeer-review

126 Scopus citations

Abstract

The current study sought to validate radioactive seed localization (RSL) as an alternative to wire localization (WL) to facilitate the operative excision of nonpalpable breast lesions. One hundred consecutive patients underwent preoperative WL and the next 100 RSL. Margins were considered negative if ≥2 mm from in situ and invasive disease. RSL resulted in 100% retrieval of the seeds and lesions. Sixty-eight percent of patients underwent RSL at least 1 day before surgery. RSL resulted in a 35% relative improvement in the rate of negative margins in the first specimen (P = 0.01) and a 62% relative improvement in the rate of reoperation for positive margins (P = 0.01). The sentinel lymph node (SLN) identification rate was 100% in both groups. RSL is effective and safe, and this procedure significantly improved the rate of negative margins in the first specimen and the rate of reoperation for positive margins compared to WL. We highly favor RSL over WL.

Original languageEnglish (US)
Pages (from-to)377-380
Number of pages4
JournalAmerican journal of surgery
Volume188
Issue number4 SPEC. ISS.
DOIs
StatePublished - Oct 2004

Keywords

  • Breast cancer
  • Nonpalpable
  • Radioactive seed localization
  • Wire localization

ASJC Scopus subject areas

  • Surgery

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