Radioactive seed localization for nonpalpable breast lesions: Review of 1,000 consecutive procedures at a single institution

Lee J. McGhan, Sara C. McKeever, Barbara A. Pockaj, Nabil Wasif, Marina E. Giurescu, Heidi A. Walton, Richard J. Gray

Research output: Contribution to journalArticlepeer-review

86 Scopus citations


Introduction. Radioactive seed localization (RSL) is an alternative to wire localization for nonpalpable breast lesions, with reported lower rates of positive surgical margins. Methods: A retrospective review of all consecutive RSL procedures performed at a single institution from 01/2003 through 10/2010 was conducted. Results: One thousand RSL breast procedures were performed in 978 patients. Indications for RSL included invasive carcinoma (52%), in situ carcinoma (22%), atypical hyperplasia (11%), and suspicious percutaneous biopsy findings (15%). A total of 1,148 seeds were deployed using image guidance, with 76% placed ≥1 day before surgery. Most procedures (86%) utilized one seed. A negative margin was achieved at the first operation in 97% of patients with invasive carcinoma and 97% of patients with ductal carcinoma in situ (DCIS). An additional 9% of patients with invasive carcinoma and 19% of patients with DCIS had close (≤2 mm) margins, and underwent re-excision. Sentinel lymph node biopsy was successfully performed in 99.8% of cases. Adverse events included 3 seeds (0.3%) not deployed correctly on first attempt and 30 seeds (2.6%) displaced from the breast specimen during excision of the targeted lesion. All seeds were successfully retrieved, with no radiation safety concerns. Local recurrence rates were 0.9% for invasive breast cancer and 3% for DCIS after mean follow-up of 33 months. There was no evidence of a learning curve. Conclusions: RSL is a safe, effective procedure that is easy to learn, with a low incidence of positive/close margins. RSL should be considered as the method of choice for localization of nonpalpable breast lesions.

Original languageEnglish (US)
Pages (from-to)3096-3101
Number of pages6
JournalAnnals of surgical oncology
Issue number11
StatePublished - Oct 2011

ASJC Scopus subject areas

  • Surgery
  • Oncology


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