TY - JOUR
T1 - Radio frequency dual-spectra analysis of regional myocardial perfusion
T2 - Comparison with harmonic densitometric method
AU - Asanuma, Toshihiko
AU - Khandheria, Bijoy K.
AU - Seward, James B.
AU - Belohlavek, Marek
N1 - Funding Information:
Supported by a grant from General Electric Medical Systems (Milwaukee, Wis). The ultrasound contrast agent was provided by Bracco Research S.A. (Geneva, Switzerland). T.A. was supported by grants from the Japanese Society of Echocardiography (Osaka, Japan) and the Fukuda Foundation for Medical Technology (Tokyo, Japan).
Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2002/10/1
Y1 - 2002/10/1
N2 - Our objective was to compare harmonic-to-fundamental frequency ratio peak (HFRp) analysis with conventional harmonic gray-scale densitometric analysis on the basis of ability to eliminate heterogeneity in ultrasound signals. Broadband radio frequency and harmonic data were obtained by using intermittent short-axis scans in 10 open-chest pigs before and during infusion of contrast microbubbles. HFRp and gray-scale intensity values were measured in 6 segments of left ventricular myocardium. In baseline images, the influence of anisotropy on HFRp values was significantly less than that in gray-scale intensities. In perfusion assessment with subtraction, contrast heterogeneity in HFRp values was significantly smaller than that in gray-scale intensities. The increase in HFRp values after subtraction was significantly greater than that in gray-scale intensities in lateral (P < .001), posterior (P < .0001), and inferior (P < .01) myocardium. HFRp analysis can compensate for baseline myocardial anisotropy and regional contrast heterogeneity. With background subtraction, HFRp analysis allows better quantification of myocardial perfusion.
AB - Our objective was to compare harmonic-to-fundamental frequency ratio peak (HFRp) analysis with conventional harmonic gray-scale densitometric analysis on the basis of ability to eliminate heterogeneity in ultrasound signals. Broadband radio frequency and harmonic data were obtained by using intermittent short-axis scans in 10 open-chest pigs before and during infusion of contrast microbubbles. HFRp and gray-scale intensity values were measured in 6 segments of left ventricular myocardium. In baseline images, the influence of anisotropy on HFRp values was significantly less than that in gray-scale intensities. In perfusion assessment with subtraction, contrast heterogeneity in HFRp values was significantly smaller than that in gray-scale intensities. The increase in HFRp values after subtraction was significantly greater than that in gray-scale intensities in lateral (P < .001), posterior (P < .0001), and inferior (P < .01) myocardium. HFRp analysis can compensate for baseline myocardial anisotropy and regional contrast heterogeneity. With background subtraction, HFRp analysis allows better quantification of myocardial perfusion.
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U2 - 10.1067/mje.2002.122967
DO - 10.1067/mje.2002.122967
M3 - Article
C2 - 12411917
AN - SCOPUS:0036783221
SN - 0894-7317
VL - 15
SP - 1277
EP - 1284
JO - Journal of the American Society of Echocardiography
JF - Journal of the American Society of Echocardiography
IS - 10 II
ER -