Radical prostatectomy for high-risk prostate cancer

Robert Jeffrey Karnes, Tadashi Hatano, Michael L. Blute, Robert P. Myers

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The prostate-specific antigen (PSA) era has changed the pattern of prostate cancer at presentation. Patients now present with lower-stage, lower-risk disease. However, some patients continue to present with high-risk prostate cancer (high-risk PC), and the effect of PSA introduction on outcome is less clear. This review highlights the salient features of why radical prostatectomy should be considered in the management of men with high-risk PC (Gleason score 8-10, marked increase in PSA levels and advanced clinical T stage). Radical retropubic prostatectomy (RRP) can provide durable local control, long-term cancer-specific survival and accurate pathologic staging, and may guide further individualized treatment. For these reasons, RRP remains the best single treatment of high-risk PC in operable patients.

Original languageEnglish (US)
Article numberhyp130
Pages (from-to)3-9
Number of pages7
JournalJapanese Journal of Clinical Oncology
Volume40
Issue number1
DOIs
StatePublished - Oct 19 2009

Fingerprint

Prostatectomy
Prostatic Neoplasms
Prostate-Specific Antigen
Neoplasm Grading
Survival
Therapeutics
Neoplasms

Keywords

  • Prostate-specific antigen
  • Prostatectomy
  • Prostatic neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Radiology Nuclear Medicine and imaging

Cite this

Radical prostatectomy for high-risk prostate cancer. / Karnes, Robert Jeffrey; Hatano, Tadashi; Blute, Michael L.; Myers, Robert P.

In: Japanese Journal of Clinical Oncology, Vol. 40, No. 1, hyp130, 19.10.2009, p. 3-9.

Research output: Contribution to journalArticle

Karnes, Robert Jeffrey ; Hatano, Tadashi ; Blute, Michael L. ; Myers, Robert P. / Radical prostatectomy for high-risk prostate cancer. In: Japanese Journal of Clinical Oncology. 2009 ; Vol. 40, No. 1. pp. 3-9.
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