Radiation Triggers a Dynamic Sequence of Transient Microglial Alterations in Juvenile Brain

Ahmed M. Osman, Ying Sun, Terry C. Burns, Liqun He, Nigel Kee, Nuria Oliva-Vilarnau, Androniki Alevyzaki, Kai Zhou, Lauri Louhivuori, Per Uhlén, Eva Hedlund, Christer Betsholtz, Volker M. Lauschke, Julianna Kele, Klas Blomgren

Research output: Contribution to journalArticle

Abstract

Osman et al. show that microglia undergo transient changes after radiation, displaying a series of temporally distinct molecular signatures with a trajectory toward baseline within one week and suggesting a narrow time window for any therapeutic interventions specifically targeting early microglial activation after irradiation.

Original languageEnglish (US)
Article number107699
JournalCell reports
Volume31
Issue number9
DOIs
StatePublished - Jun 2 2020

Keywords

  • M1 and M2
  • neuroinflammation
  • radiotherapy
  • RNA sequencing
  • transcriptome

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Dive into the research topics of 'Radiation Triggers a Dynamic Sequence of Transient Microglial Alterations in Juvenile Brain'. Together they form a unique fingerprint.

  • Cite this

    Osman, A. M., Sun, Y., Burns, T. C., He, L., Kee, N., Oliva-Vilarnau, N., Alevyzaki, A., Zhou, K., Louhivuori, L., Uhlén, P., Hedlund, E., Betsholtz, C., Lauschke, V. M., Kele, J., & Blomgren, K. (2020). Radiation Triggers a Dynamic Sequence of Transient Microglial Alterations in Juvenile Brain. Cell reports, 31(9), [107699]. https://doi.org/10.1016/j.celrep.2020.107699