Radiation-induced rhabdomyosarcoma of the brainstem in a patient with neurofibromatosis Type 2: Case report

Matthew L. Carlson, Dusica Babovic-Vuksanovic, Ludwi N E Messiaen, Bernd W. Scheithauer, Brian A. Neff, Michael J. Link

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Neurofibromatosis Type 2 (NF2) is a rare autosomal dominant disorder characterized by the development of benign tumors of the peripheral nervous system and the CNS, including schwannomas, meningiomas, and ependymomas. The gene responsible for the development of NF2 acts as a tumor suppressor gene. Stereotactic radiotherapy (SRT) or single-fraction stereotactic radiosurgery has been increasingly used in the past decades to treat benign tumors in patients with NF2. These radiotherapy methods are less invasive and can be potentially used to treat multiple tumors in a single session. The risk of inducing malignancy is unclear. Few reports exist of malignant peripheral nerve sheath tumors, meningiomas, or ependymomas occurring after SRT or stereotactic radiosurgery in patients with NF2. The authors present the first documented case of rhabdomyosarcoma following SRT for multiple NF2-associated schwannomas. Compared with patients with sporadic tumors, NF2 patients having a germline tumor suppressor gene defect may be more prone to secondary malignancies after treatment involving radiation therapy.

Original languageEnglish (US)
Pages (from-to)81-87
Number of pages7
JournalJournal of Neurosurgery
Volume112
Issue number1
DOIs
StatePublished - Jan 2010

Fingerprint

Neurofibromatosis 2
Rhabdomyosarcoma
Brain Stem
Radiation
Radiotherapy
Neurilemmoma
Ependymoma
Radiosurgery
Meningioma
Neoplasms
Tumor Suppressor Genes
Nervous System Neoplasms
Peripheral Nervous System
Genes

Keywords

  • Neurofibromatosis Type 2
  • Radiation-induced malignancy
  • Rhabdomyosarcoma
  • Stereotactic radiotherapy

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

Radiation-induced rhabdomyosarcoma of the brainstem in a patient with neurofibromatosis Type 2 : Case report. / Carlson, Matthew L.; Babovic-Vuksanovic, Dusica; Messiaen, Ludwi N E; Scheithauer, Bernd W.; Neff, Brian A.; Link, Michael J.

In: Journal of Neurosurgery, Vol. 112, No. 1, 01.2010, p. 81-87.

Research output: Contribution to journalArticle

Carlson, Matthew L. ; Babovic-Vuksanovic, Dusica ; Messiaen, Ludwi N E ; Scheithauer, Bernd W. ; Neff, Brian A. ; Link, Michael J. / Radiation-induced rhabdomyosarcoma of the brainstem in a patient with neurofibromatosis Type 2 : Case report. In: Journal of Neurosurgery. 2010 ; Vol. 112, No. 1. pp. 81-87.
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