Radiation-Induced Laryngeal Mucous Membrane Pemphigoid

Amit Syal; David G. Lott; William E. Karle

doi:10.1177/00034894221139121

Radiation-Induced Laryngeal Mucous Membrane Pemphigoid

Amit Syal, David G. Lott, William E. Karle

Otolaryngology- Head & Neck Surgery/Audiology

Research output: Contribution to journal › Article › peer-review

Abstract

Objectives: Bullous pemphigoid has previously been linked to radiotherapy, but here we report the first case of MMP suspected to be a consequence of RT. Methods: The patient described is an 85-year-old male who underwent RT to treat squamous cell carcinoma of the palatine tonsil. Shortly after therapy, the patient developed blisters with worsening dyspnea and dysphonia. Results: This patient was successfully treated with a combination of oral immunosuppressants and surgical intervention. Conclusion: This incident underscores that not all episodes of mucosal ulceration following radiation are a result of mucositis and MMP should be considered in the differential. Level of evidence: Level 4.

Original language	English (US)
Journal	Annals of Otology, Rhinology and Laryngology
DOIs	https://doi.org/10.1177/00034894221139121
State	Accepted/In press - 2022

Keywords

bullous pemphigoid
mucous membrane pemphigoid
radiation therapy
supraglottic stenosis

ASJC Scopus subject areas

Otorhinolaryngology

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10.1177/00034894221139121

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title = "Radiation-Induced Laryngeal Mucous Membrane Pemphigoid",

abstract = "Objectives: Bullous pemphigoid has previously been linked to radiotherapy, but here we report the first case of MMP suspected to be a consequence of RT. Methods: The patient described is an 85-year-old male who underwent RT to treat squamous cell carcinoma of the palatine tonsil. Shortly after therapy, the patient developed blisters with worsening dyspnea and dysphonia. Results: This patient was successfully treated with a combination of oral immunosuppressants and surgical intervention. Conclusion: This incident underscores that not all episodes of mucosal ulceration following radiation are a result of mucositis and MMP should be considered in the differential. Level of evidence: Level 4.",

keywords = "bullous pemphigoid, mucous membrane pemphigoid, radiation therapy, supraglottic stenosis",

author = "Amit Syal and Lott, {David G.} and Karle, {William E.}",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2022.",

year = "2022",

doi = "10.1177/00034894221139121",

language = "English (US)",

journal = "Annals of Otology, Rhinology and Laryngology",

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TY - JOUR

T1 - Radiation-Induced Laryngeal Mucous Membrane Pemphigoid

AU - Syal, Amit

AU - Lott, David G.

AU - Karle, William E.

N1 - Publisher Copyright: © The Author(s) 2022.

PY - 2022

Y1 - 2022

N2 - Objectives: Bullous pemphigoid has previously been linked to radiotherapy, but here we report the first case of MMP suspected to be a consequence of RT. Methods: The patient described is an 85-year-old male who underwent RT to treat squamous cell carcinoma of the palatine tonsil. Shortly after therapy, the patient developed blisters with worsening dyspnea and dysphonia. Results: This patient was successfully treated with a combination of oral immunosuppressants and surgical intervention. Conclusion: This incident underscores that not all episodes of mucosal ulceration following radiation are a result of mucositis and MMP should be considered in the differential. Level of evidence: Level 4.

AB - Objectives: Bullous pemphigoid has previously been linked to radiotherapy, but here we report the first case of MMP suspected to be a consequence of RT. Methods: The patient described is an 85-year-old male who underwent RT to treat squamous cell carcinoma of the palatine tonsil. Shortly after therapy, the patient developed blisters with worsening dyspnea and dysphonia. Results: This patient was successfully treated with a combination of oral immunosuppressants and surgical intervention. Conclusion: This incident underscores that not all episodes of mucosal ulceration following radiation are a result of mucositis and MMP should be considered in the differential. Level of evidence: Level 4.

KW - bullous pemphigoid

KW - mucous membrane pemphigoid

KW - radiation therapy

KW - supraglottic stenosis

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ER -

Radiation-Induced Laryngeal Mucous Membrane Pemphigoid

Abstract

Keywords

ASJC Scopus subject areas

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