Radiation-induced cell death and dendritic cells: Potential for cancer immunotherapy?

Paul Hatfield., A. Merrick, K. Harrington, R. Vile, A. Bateman, A. Selby, A. Melcher

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

Dendritic cells are key orchestrators of the immune system. There is considerable interest in their use for treating cancer. Whether they initiate an effective cytotoxic response against antigen-bearing cells, or produce tolerance, depends on the context in which those antigens are presented. Ionising radiation, and the cell death it causes, has several properties that may facilitate such an effective response. A range of in-vitro and in-vivo data supports this, although potential problems exist that may require concurrent strategies.

Original languageEnglish (US)
Pages (from-to)1-11
Number of pages11
JournalClinical Oncology
Volume17
Issue number1
DOIs
StatePublished - Feb 2005

Keywords

  • Apoptosis
  • Cell death
  • Dendritic cells
  • Immunotherapy
  • Ionising radiation
  • Necrosis

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging

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    Hatfield., P., Merrick, A., Harrington, K., Vile, R., Bateman, A., Selby, A., & Melcher, A. (2005). Radiation-induced cell death and dendritic cells: Potential for cancer immunotherapy? Clinical Oncology, 17(1), 1-11. https://doi.org/10.1016/j.clon.2004.06.014