Radiation-induced cell death and dendritic cells: Potential for cancer immunotherapy?

Paul Hatfield., A. Merrick, K. Harrington, Richard Geoffrey Vile, A. Bateman, A. Selby, A. Melcher

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Dendritic cells are key orchestrators of the immune system. There is considerable interest in their use for treating cancer. Whether they initiate an effective cytotoxic response against antigen-bearing cells, or produce tolerance, depends on the context in which those antigens are presented. Ionising radiation, and the cell death it causes, has several properties that may facilitate such an effective response. A range of in-vitro and in-vivo data supports this, although potential problems exist that may require concurrent strategies.

Original languageEnglish (US)
Pages (from-to)1-11
Number of pages11
JournalClinical Oncology
Volume17
Issue number1
DOIs
StatePublished - Feb 2005

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Immunotherapy
Dendritic Cells
Cell Death
Radiation
Antigens
Ionizing Radiation
Immune System
Neoplasms
In Vitro Techniques

Keywords

  • Apoptosis
  • Cell death
  • Dendritic cells
  • Immunotherapy
  • Ionising radiation
  • Necrosis

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging

Cite this

Hatfield., P., Merrick, A., Harrington, K., Vile, R. G., Bateman, A., Selby, A., & Melcher, A. (2005). Radiation-induced cell death and dendritic cells: Potential for cancer immunotherapy? Clinical Oncology, 17(1), 1-11. https://doi.org/10.1016/j.clon.2004.06.014

Radiation-induced cell death and dendritic cells : Potential for cancer immunotherapy? / Hatfield., Paul; Merrick, A.; Harrington, K.; Vile, Richard Geoffrey; Bateman, A.; Selby, A.; Melcher, A.

In: Clinical Oncology, Vol. 17, No. 1, 02.2005, p. 1-11.

Research output: Contribution to journalArticle

Hatfield., P, Merrick, A, Harrington, K, Vile, RG, Bateman, A, Selby, A & Melcher, A 2005, 'Radiation-induced cell death and dendritic cells: Potential for cancer immunotherapy?', Clinical Oncology, vol. 17, no. 1, pp. 1-11. https://doi.org/10.1016/j.clon.2004.06.014
Hatfield., Paul ; Merrick, A. ; Harrington, K. ; Vile, Richard Geoffrey ; Bateman, A. ; Selby, A. ; Melcher, A. / Radiation-induced cell death and dendritic cells : Potential for cancer immunotherapy?. In: Clinical Oncology. 2005 ; Vol. 17, No. 1. pp. 1-11.
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