TY - JOUR
T1 - Radiation dose efficiency of multi-energy photon-counting-detector CT for dual-contrast imaging
AU - Ren, Liqiang
AU - Rajendran, Kishore
AU - McCollough, Cynthia H.
AU - Yu, Lifeng
N1 - Funding Information:
Research reported in this publication was supported by the National Institutes of Health under award numbers R21 EB024071, R01 EB016966, and C06 RR018898. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Dr McCollough receives industry grant support from Siemens. No other potential conflicts of interest were declared. Supplies and services for this study were provided by Mayo Clinic's X-Ray Imaging Core. The authors would like to thank Sonia Watson, PhD, for assistance with editing the manuscript.
Publisher Copyright:
© 2019 Institute of Physics and Engineering in Medicine.
PY - 2019/12/13
Y1 - 2019/12/13
N2 - Compared to traditional multi-scan single-energy CT (SECT), one potential advantage of single-scan multi-energy CT (MECT) proposed for simultaneous imaging of multiple contrast agents is the radiation dose reduction. This phantom study aims to rigorously evaluate whether the radiation dose can truly be reduced in a single-scan MECT protocol (MECT_1s) in biphasic liver imaging with iodine and gadolinium, and small bowel imaging with iodine and bismuth, compared to traditional two-scan SECT protocols (SECT_2s). For MECT_1s, mixed iodine/gadolinium samples were prepared corresponding to late arterial/portal-venous phase for biphasic liver imaging. Mixed iodine/bismuth samples were prepared representing the arterial/enteric enhancement for small bowel imaging. For SECT_2s, separate contrast samples were prepared to mimic separate scans in arterial/venous phase and arterial/enteric enhancement. Samples were placed in a 35 cm wide water phantom and scanned by a research whole-body photon-counting-detector-CT (PCD-CT) system ('chess' mode). MECT images were acquired with optimized kV/threshold settings for each imaging task, and SECT images were acquired at 120 kV. Total CTDIvol was matched for the two protocols. Image-based three-material decomposition was employed in MECT_1s to determine the basis material concentration values, which were converted to CT numbers at 120 kV (i.e. virtual SECT images) to compare with the SECT images directly acquired with SECT_2s. The noise difference between the SECT and the virtual SECT images was compared to evaluate the dose efficiency of MECT_1s. Compared to SECT_2s, MECT_1s was not dose efficient for both imaging tasks. The amount of noise increase is highly task dependent, with noise increased by 203%/278% and 110%/82% in virtual SECT images for iodine/gadolinium and iodine/bismuth quantifications, respectively, corresponding to dose increase by 819%/1328% and 340%/230% in MECT_1s to achieve the same image noise level. MECT with the current PCD-CT technique requires higher radiation dose than SECT to achieve the same image quality.
AB - Compared to traditional multi-scan single-energy CT (SECT), one potential advantage of single-scan multi-energy CT (MECT) proposed for simultaneous imaging of multiple contrast agents is the radiation dose reduction. This phantom study aims to rigorously evaluate whether the radiation dose can truly be reduced in a single-scan MECT protocol (MECT_1s) in biphasic liver imaging with iodine and gadolinium, and small bowel imaging with iodine and bismuth, compared to traditional two-scan SECT protocols (SECT_2s). For MECT_1s, mixed iodine/gadolinium samples were prepared corresponding to late arterial/portal-venous phase for biphasic liver imaging. Mixed iodine/bismuth samples were prepared representing the arterial/enteric enhancement for small bowel imaging. For SECT_2s, separate contrast samples were prepared to mimic separate scans in arterial/venous phase and arterial/enteric enhancement. Samples were placed in a 35 cm wide water phantom and scanned by a research whole-body photon-counting-detector-CT (PCD-CT) system ('chess' mode). MECT images were acquired with optimized kV/threshold settings for each imaging task, and SECT images were acquired at 120 kV. Total CTDIvol was matched for the two protocols. Image-based three-material decomposition was employed in MECT_1s to determine the basis material concentration values, which were converted to CT numbers at 120 kV (i.e. virtual SECT images) to compare with the SECT images directly acquired with SECT_2s. The noise difference between the SECT and the virtual SECT images was compared to evaluate the dose efficiency of MECT_1s. Compared to SECT_2s, MECT_1s was not dose efficient for both imaging tasks. The amount of noise increase is highly task dependent, with noise increased by 203%/278% and 110%/82% in virtual SECT images for iodine/gadolinium and iodine/bismuth quantifications, respectively, corresponding to dose increase by 819%/1328% and 340%/230% in MECT_1s to achieve the same image noise level. MECT with the current PCD-CT technique requires higher radiation dose than SECT to achieve the same image quality.
KW - material decomposition
KW - multi-energy CT
KW - photon-counting-detector CT
KW - radiation dose efficiency
KW - single-energy CT
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U2 - 10.1088/1361-6560/ab55bf
DO - 10.1088/1361-6560/ab55bf
M3 - Article
C2 - 31703217
AN - SCOPUS:85076380439
SN - 0031-9155
VL - 64
JO - Physics in Medicine and Biology
JF - Physics in Medicine and Biology
IS - 24
M1 - 245003
ER -