Racial disparities in uterine clear cell carcinoma: A multi-institution study

Zaid R. Al-Wahab, Sanjeev Kumar, David G. Mutch, Sean C. Dowdy, Sharon A. Hensley, Yun Wang, Hidar Mahdi, Rouba Ali-Fehmi, Robert T. Morris, Mohammed Elshaikh, Adnan R. Munkarah

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Objective: The aim of this study was to evaluate the impact of race on the overall survival (OS) and progression-free survival (PFS) of white and African-American patients with uterine clear cell carcinoma (UCCC). Methods: A retrospective review was conducted of all primary UCCC cases treated at 1 of 4 major gynecologic cancer centers between 1982 and 2012. Patients and tumor characteristics were retrieved from the cancer databases of the respective institutions and based on a retrospective review of the medical records. Differences in the OS and PFS between African-American and white women were compared using the Kaplan-Meier curves and log-rank test for univariate analysis. Cox regression models for the multivariate analyses were built to evaluate the relative impact of the various prognostic factors. Results: One hundred seventy women with UCCC were included in the study, including 118 white and 52 African-American women. Both groups were comparable with respect to age (P = 0.9), stage at diagnosis (P = 0.34), angiolymphatic invasion (P = 0.3), and depth of myometrial invasion (P = 0.84). In the multivariate analyses for known prognostic factors, OS and PFS were significantly different between white and African-American patients in the early-stage disease (hazard ratio [HR], 5.4; 95% confidence interval [CI], 1.2-23.2; P = 0.023 and HR, 3.5; 95% CI, 1.60-7.77; P = 0.0016, respectively) but not in the advancedstage disease (HR, 0.83; 95% CI, 0.40-1.67; P = 0.61 and HR, 1.5; 95% CI, 0.84-2.78; P = 0.15, respectively). Conclusions: In the current study, African-American patients have a prognosis worse than that of white patients in early-stage UCCC. We could not prove the same difference in advanced-stage disease.

Original languageEnglish (US)
Pages (from-to)541-548
Number of pages8
JournalInternational Journal of Gynecological Cancer
Volume24
Issue number3
DOIs
StatePublished - Mar 2014

Keywords

  • African American
  • Clear cell carcinoma
  • Clear cell endometrial cancer
  • Race
  • Racial disparities
  • Survival
  • Uterine clear cell carcinoma
  • White

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynecology

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  • Cite this

    Al-Wahab, Z. R., Kumar, S., Mutch, D. G., Dowdy, S. C., Hensley, S. A., Wang, Y., Mahdi, H., Ali-Fehmi, R., Morris, R. T., Elshaikh, M., & Munkarah, A. R. (2014). Racial disparities in uterine clear cell carcinoma: A multi-institution study. International Journal of Gynecological Cancer, 24(3), 541-548. https://doi.org/10.1097/IGC.0000000000000068