Racial disparities in the prevalence of monoclonal gammopathies: A population-based study of 12 482 persons from the national health and nutritional examination survey

O. Landgren, B. I. Graubard, J. A. Katzmann, R. A. Kyle, I. Ahmadizadeh, R. Clark, S. K. Kumar, A. Dispenzieri, A. J. Greenberg, T. M. Therneau, L. J. Melton, N. Caporaso, N. Korde, M. Roschewski, R. Costello, G. M. McQuillan, S. V. Rajkumar

Research output: Contribution to journalReview article

71 Scopus citations

Abstract

Multiple myeloma (MM) incidence is markedly higher in blacks compared with whites, which may be related to a higher prevalence of monoclonal gammopathy of undetermined significance (MGUS). Our objective was to define the prevalence and risk factors of MGUS in a large cohort representative of the US population. Stored serum samples from the National Health and Nutritional Examination Survey (NHANES) III or NHANES 1999-2004 were available for 12 482 individuals of age ≥50 years (2331 'blacks', 2475 Hispanics, 7051 'whites' and 625 'others') on which agarose-gel electrophoresis, serum protein immunofixation, serum-free light-chain assay and M-protein typing were performed. MGUS was identified in 365 participants (2.4%). Adjusted prevalence of MGUS was significantly higher (P<0.001) in blacks (3.7%) compared with whites (2.3%) (P=0.001) or Hispanics (1.8%), as were characteristics that posed a greater risk of progression to MM. The adjusted prevalence of MGUS was 3.1% and 2.1% for the North/Midwest versus South/West regions of the United States, respectively (P=0.052). MGUS is significantly more common in blacks, and more often has features associated with higher risk of progression to MM. A strong geographic disparity in the prevalence of MGUS between the North/Midwest versus the South/West regions of the United States was found, which has etiologic implications.

Original languageEnglish (US)
Pages (from-to)1537-1542
Number of pages6
JournalLeukemia
Volume28
Issue number7
DOIs
StatePublished - Jul 2014

Keywords

  • biomarker
  • monoclonal gammopathy
  • prevalence
  • prognosis
  • racial disparity

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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    Landgren, O., Graubard, B. I., Katzmann, J. A., Kyle, R. A., Ahmadizadeh, I., Clark, R., Kumar, S. K., Dispenzieri, A., Greenberg, A. J., Therneau, T. M., Melton, L. J., Caporaso, N., Korde, N., Roschewski, M., Costello, R., McQuillan, G. M., & Rajkumar, S. V. (2014). Racial disparities in the prevalence of monoclonal gammopathies: A population-based study of 12 482 persons from the national health and nutritional examination survey. Leukemia, 28(7), 1537-1542. https://doi.org/10.1038/leu.2014.34