Racial differences in vestibular schwannoma

Matthew L. Carlson, Alexander P. Marston, Amy E. Glasgow, Elizabeth B Habermann, Alex D. Sweeney, Michael J. Link, George B. Wanna

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Objectives/Hypothesis: To estimate the impact of race on disease presentation and treatment of vestibular schwannoma (VS) in the United States. Study Design: Analysis of a national population-based tumor registry. Methods: Analysis of the Surveillance, Epidemiology, and End Results database was performed, including all patients identified with a diagnosis of VS. Associations between race, disease presentation, treatment strategy, and overall survival were analyzed in a univariate and multivariable model. Results: A total of 9,782 patients with VS were identified among 822 million person-years. Of these, 7,400 (75.6%) claimed white, 807 (8.2%) Hispanic, 755 (7.7%) Asian, 397 (4.1%) black, and 423 (4.3%) patients reported other race. The median annual incidence of disease was lowest among black (0.43 per 100,000 persons) and Hispanic populations (0.45 per 100,000 persons) and highest among white (1.61 per 100,000 persons) populations (P < 0.001). Overall, Hispanic patients were diagnosed at the youngest age, and white patients were diagnosed at the oldest age (mean of 50.0 vs. 56.0 years, respectively; P < 0.001). Compared to white populations, black, Hispanic, and Asian populations were more likely to present with larger tumors (P < 0.001). After controlling for tumor size, age, and treatment center in a multivariable model, Hispanic patients were more likely than white patients to undergo surgery (P = 0.010); however, there were no differences between white, black, and Asian populations with regard to treatment modality. Hispanic and black patients had the poorest overall survival following surgery compared to other groups. Conclusion: Racial differences among patients with VS exist within the United States. Further studies are required to determine which factors drive differences in tumor size, age, annual disease incidence, and overall survival between races. Level of Evidence: 3. Laryngoscope, 126:2128–2133, 2016.

Original languageEnglish (US)
Pages (from-to)2128-2133
Number of pages6
JournalLaryngoscope
Volume126
Issue number9
DOIs
StatePublished - Sep 1 2016

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Acoustic Neuroma
Hispanic Americans
Population
Survival
Neoplasms
Laryngoscopes
Incidence
Therapeutics
Registries
Epidemiology
Databases

Keywords

  • Acoustic neuroma
  • epidemiology
  • microsurgery
  • race
  • skull base
  • stereotactic radiosurgery
  • vestibular schwannoma

ASJC Scopus subject areas

  • Medicine(all)
  • Otorhinolaryngology

Cite this

Carlson, M. L., Marston, A. P., Glasgow, A. E., Habermann, E. B., Sweeney, A. D., Link, M. J., & Wanna, G. B. (2016). Racial differences in vestibular schwannoma. Laryngoscope, 126(9), 2128-2133. https://doi.org/10.1002/lary.25892

Racial differences in vestibular schwannoma. / Carlson, Matthew L.; Marston, Alexander P.; Glasgow, Amy E.; Habermann, Elizabeth B; Sweeney, Alex D.; Link, Michael J.; Wanna, George B.

In: Laryngoscope, Vol. 126, No. 9, 01.09.2016, p. 2128-2133.

Research output: Contribution to journalArticle

Carlson, ML, Marston, AP, Glasgow, AE, Habermann, EB, Sweeney, AD, Link, MJ & Wanna, GB 2016, 'Racial differences in vestibular schwannoma', Laryngoscope, vol. 126, no. 9, pp. 2128-2133. https://doi.org/10.1002/lary.25892
Carlson ML, Marston AP, Glasgow AE, Habermann EB, Sweeney AD, Link MJ et al. Racial differences in vestibular schwannoma. Laryngoscope. 2016 Sep 1;126(9):2128-2133. https://doi.org/10.1002/lary.25892
Carlson, Matthew L. ; Marston, Alexander P. ; Glasgow, Amy E. ; Habermann, Elizabeth B ; Sweeney, Alex D. ; Link, Michael J. ; Wanna, George B. / Racial differences in vestibular schwannoma. In: Laryngoscope. 2016 ; Vol. 126, No. 9. pp. 2128-2133.
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abstract = "Objectives/Hypothesis: To estimate the impact of race on disease presentation and treatment of vestibular schwannoma (VS) in the United States. Study Design: Analysis of a national population-based tumor registry. Methods: Analysis of the Surveillance, Epidemiology, and End Results database was performed, including all patients identified with a diagnosis of VS. Associations between race, disease presentation, treatment strategy, and overall survival were analyzed in a univariate and multivariable model. Results: A total of 9,782 patients with VS were identified among 822 million person-years. Of these, 7,400 (75.6{\%}) claimed white, 807 (8.2{\%}) Hispanic, 755 (7.7{\%}) Asian, 397 (4.1{\%}) black, and 423 (4.3{\%}) patients reported other race. The median annual incidence of disease was lowest among black (0.43 per 100,000 persons) and Hispanic populations (0.45 per 100,000 persons) and highest among white (1.61 per 100,000 persons) populations (P < 0.001). Overall, Hispanic patients were diagnosed at the youngest age, and white patients were diagnosed at the oldest age (mean of 50.0 vs. 56.0 years, respectively; P < 0.001). Compared to white populations, black, Hispanic, and Asian populations were more likely to present with larger tumors (P < 0.001). After controlling for tumor size, age, and treatment center in a multivariable model, Hispanic patients were more likely than white patients to undergo surgery (P = 0.010); however, there were no differences between white, black, and Asian populations with regard to treatment modality. Hispanic and black patients had the poorest overall survival following surgery compared to other groups. Conclusion: Racial differences among patients with VS exist within the United States. Further studies are required to determine which factors drive differences in tumor size, age, annual disease incidence, and overall survival between races. Level of Evidence: 3. Laryngoscope, 126:2128–2133, 2016.",
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N2 - Objectives/Hypothesis: To estimate the impact of race on disease presentation and treatment of vestibular schwannoma (VS) in the United States. Study Design: Analysis of a national population-based tumor registry. Methods: Analysis of the Surveillance, Epidemiology, and End Results database was performed, including all patients identified with a diagnosis of VS. Associations between race, disease presentation, treatment strategy, and overall survival were analyzed in a univariate and multivariable model. Results: A total of 9,782 patients with VS were identified among 822 million person-years. Of these, 7,400 (75.6%) claimed white, 807 (8.2%) Hispanic, 755 (7.7%) Asian, 397 (4.1%) black, and 423 (4.3%) patients reported other race. The median annual incidence of disease was lowest among black (0.43 per 100,000 persons) and Hispanic populations (0.45 per 100,000 persons) and highest among white (1.61 per 100,000 persons) populations (P < 0.001). Overall, Hispanic patients were diagnosed at the youngest age, and white patients were diagnosed at the oldest age (mean of 50.0 vs. 56.0 years, respectively; P < 0.001). Compared to white populations, black, Hispanic, and Asian populations were more likely to present with larger tumors (P < 0.001). After controlling for tumor size, age, and treatment center in a multivariable model, Hispanic patients were more likely than white patients to undergo surgery (P = 0.010); however, there were no differences between white, black, and Asian populations with regard to treatment modality. Hispanic and black patients had the poorest overall survival following surgery compared to other groups. Conclusion: Racial differences among patients with VS exist within the United States. Further studies are required to determine which factors drive differences in tumor size, age, annual disease incidence, and overall survival between races. Level of Evidence: 3. Laryngoscope, 126:2128–2133, 2016.

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