Racial difference in cardiac sarcoidosis incidence observed at autopsy.

K. Iwai, M. Sekiguti, Y. Hosoda, R. A. DeRemee, H. D. Tazelaar, O. P. Sharma, A. Maheshwari, T. I. Noguchi

Research output: Contribution to journalArticle

202 Citations (Scopus)

Abstract

The most commonly involved organ in sarcoid related death has been reported to be the lung in western countries, while it was the heart in the Japanese autopsy series. In order to verify this different pattern of death, autopsy records were reviewed in two United States institutions and in Japanese nation-wide data. In Japanese, male to female ratio was 1:2 and a high frequency of sarcoidosis in females over 50 years of age was observed. Male to female ratio in Caucasian sarcoidosis autopsy was nearly 1:1. In Afroamericans, it was nearly 1:2, and the age distribution showed that this female predominance was due to a high number of sarcoidosis in females over 40 years of age. The frequency of sarcoidosis in Caucasian autopsies was higher than in Japanese autopsies. The number of involved organs was smaller in Caucasians than in Afroamericans or in Japanese. The incidence of cardiac sarcoid granuloma in Japanese was significantly higher than that seen in Caucasians and Afroamericans. The commonest cause of death in sarcoidosis of Caucasians and Afroamericans was from non-sarcoid diseases, while the major cause of sarcoid-attributed death was pulmonary sarcoidosis in Afroamericans. Japanese showed the highest rate of cardiac sarcoid-attributed death. Possible factors relating to this high incidence of sarcoidosis in elderly females and the racial difference in cardiac sarcoidosis were discussed.

Original languageEnglish (US)
Pages (from-to)26-31
Number of pages6
JournalSarcoidosis
Volume11
Issue number1
StatePublished - Mar 1994
Externally publishedYes

Fingerprint

Sarcoidosis
Autopsy
Incidence
Pulmonary Sarcoidosis
Death Certificates
Age Distribution
Granuloma
Cause of Death
Lung

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Iwai, K., Sekiguti, M., Hosoda, Y., DeRemee, R. A., Tazelaar, H. D., Sharma, O. P., ... Noguchi, T. I. (1994). Racial difference in cardiac sarcoidosis incidence observed at autopsy. Sarcoidosis, 11(1), 26-31.

Racial difference in cardiac sarcoidosis incidence observed at autopsy. / Iwai, K.; Sekiguti, M.; Hosoda, Y.; DeRemee, R. A.; Tazelaar, H. D.; Sharma, O. P.; Maheshwari, A.; Noguchi, T. I.

In: Sarcoidosis, Vol. 11, No. 1, 03.1994, p. 26-31.

Research output: Contribution to journalArticle

Iwai, K, Sekiguti, M, Hosoda, Y, DeRemee, RA, Tazelaar, HD, Sharma, OP, Maheshwari, A & Noguchi, TI 1994, 'Racial difference in cardiac sarcoidosis incidence observed at autopsy.', Sarcoidosis, vol. 11, no. 1, pp. 26-31.
Iwai K, Sekiguti M, Hosoda Y, DeRemee RA, Tazelaar HD, Sharma OP et al. Racial difference in cardiac sarcoidosis incidence observed at autopsy. Sarcoidosis. 1994 Mar;11(1):26-31.
Iwai, K. ; Sekiguti, M. ; Hosoda, Y. ; DeRemee, R. A. ; Tazelaar, H. D. ; Sharma, O. P. ; Maheshwari, A. ; Noguchi, T. I. / Racial difference in cardiac sarcoidosis incidence observed at autopsy. In: Sarcoidosis. 1994 ; Vol. 11, No. 1. pp. 26-31.
@article{02000869a92449d58ff341c2d8dcd049,
title = "Racial difference in cardiac sarcoidosis incidence observed at autopsy.",
abstract = "The most commonly involved organ in sarcoid related death has been reported to be the lung in western countries, while it was the heart in the Japanese autopsy series. In order to verify this different pattern of death, autopsy records were reviewed in two United States institutions and in Japanese nation-wide data. In Japanese, male to female ratio was 1:2 and a high frequency of sarcoidosis in females over 50 years of age was observed. Male to female ratio in Caucasian sarcoidosis autopsy was nearly 1:1. In Afroamericans, it was nearly 1:2, and the age distribution showed that this female predominance was due to a high number of sarcoidosis in females over 40 years of age. The frequency of sarcoidosis in Caucasian autopsies was higher than in Japanese autopsies. The number of involved organs was smaller in Caucasians than in Afroamericans or in Japanese. The incidence of cardiac sarcoid granuloma in Japanese was significantly higher than that seen in Caucasians and Afroamericans. The commonest cause of death in sarcoidosis of Caucasians and Afroamericans was from non-sarcoid diseases, while the major cause of sarcoid-attributed death was pulmonary sarcoidosis in Afroamericans. Japanese showed the highest rate of cardiac sarcoid-attributed death. Possible factors relating to this high incidence of sarcoidosis in elderly females and the racial difference in cardiac sarcoidosis were discussed.",
author = "K. Iwai and M. Sekiguti and Y. Hosoda and DeRemee, {R. A.} and Tazelaar, {H. D.} and Sharma, {O. P.} and A. Maheshwari and Noguchi, {T. I.}",
year = "1994",
month = "3",
language = "English (US)",
volume = "11",
pages = "26--31",
journal = "Sarcoidosis Vasculitis and Diffuse Lung Diseases",
issn = "1124-0490",
publisher = "Mattioli 1885 S.p.A.",
number = "1",

}

TY - JOUR

T1 - Racial difference in cardiac sarcoidosis incidence observed at autopsy.

AU - Iwai, K.

AU - Sekiguti, M.

AU - Hosoda, Y.

AU - DeRemee, R. A.

AU - Tazelaar, H. D.

AU - Sharma, O. P.

AU - Maheshwari, A.

AU - Noguchi, T. I.

PY - 1994/3

Y1 - 1994/3

N2 - The most commonly involved organ in sarcoid related death has been reported to be the lung in western countries, while it was the heart in the Japanese autopsy series. In order to verify this different pattern of death, autopsy records were reviewed in two United States institutions and in Japanese nation-wide data. In Japanese, male to female ratio was 1:2 and a high frequency of sarcoidosis in females over 50 years of age was observed. Male to female ratio in Caucasian sarcoidosis autopsy was nearly 1:1. In Afroamericans, it was nearly 1:2, and the age distribution showed that this female predominance was due to a high number of sarcoidosis in females over 40 years of age. The frequency of sarcoidosis in Caucasian autopsies was higher than in Japanese autopsies. The number of involved organs was smaller in Caucasians than in Afroamericans or in Japanese. The incidence of cardiac sarcoid granuloma in Japanese was significantly higher than that seen in Caucasians and Afroamericans. The commonest cause of death in sarcoidosis of Caucasians and Afroamericans was from non-sarcoid diseases, while the major cause of sarcoid-attributed death was pulmonary sarcoidosis in Afroamericans. Japanese showed the highest rate of cardiac sarcoid-attributed death. Possible factors relating to this high incidence of sarcoidosis in elderly females and the racial difference in cardiac sarcoidosis were discussed.

AB - The most commonly involved organ in sarcoid related death has been reported to be the lung in western countries, while it was the heart in the Japanese autopsy series. In order to verify this different pattern of death, autopsy records were reviewed in two United States institutions and in Japanese nation-wide data. In Japanese, male to female ratio was 1:2 and a high frequency of sarcoidosis in females over 50 years of age was observed. Male to female ratio in Caucasian sarcoidosis autopsy was nearly 1:1. In Afroamericans, it was nearly 1:2, and the age distribution showed that this female predominance was due to a high number of sarcoidosis in females over 40 years of age. The frequency of sarcoidosis in Caucasian autopsies was higher than in Japanese autopsies. The number of involved organs was smaller in Caucasians than in Afroamericans or in Japanese. The incidence of cardiac sarcoid granuloma in Japanese was significantly higher than that seen in Caucasians and Afroamericans. The commonest cause of death in sarcoidosis of Caucasians and Afroamericans was from non-sarcoid diseases, while the major cause of sarcoid-attributed death was pulmonary sarcoidosis in Afroamericans. Japanese showed the highest rate of cardiac sarcoid-attributed death. Possible factors relating to this high incidence of sarcoidosis in elderly females and the racial difference in cardiac sarcoidosis were discussed.

UR - http://www.scopus.com/inward/record.url?scp=0028400444&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028400444&partnerID=8YFLogxK

M3 - Article

C2 - 8036339

AN - SCOPUS:0028400444

VL - 11

SP - 26

EP - 31

JO - Sarcoidosis Vasculitis and Diffuse Lung Diseases

JF - Sarcoidosis Vasculitis and Diffuse Lung Diseases

SN - 1124-0490

IS - 1

ER -