TY - JOUR
T1 - Racial and Ethnic Disparities in Cardiovascular Disease Risk Among Patients with Chronic Kidney Disease
AU - Adedinsewo, Demilade A.
AU - Porter, Ivan E.
AU - White, Richard O.
AU - Hickson, La Tonya J.
N1 - Publisher Copyright:
© 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2022/10
Y1 - 2022/10
N2 - Purpose of Review: The purpose of this article is to critically appraise and summarize recent literature addressing racial and ethnic disparities in cardiovascular disease among adults with chronic kidney disease. Recent Findings: Despite advances in medical care, individuals with chronic kidney disease continue to bear a high burden of clinical and subclinical cardiovascular disease. Multiple racial and ethnic factors influence cardiovascular disease pathophysiology, burden, and clinical outcomes therein contributing to increased morbidity and mortality among racial and ethnic minority populations with chronic kidney disease. Summary: Racial differences in the prevalence of left ventricular hypertrophy, endothelial dysfunction, vascular calcification, and inflammation are observed in chronic kidney disease and contribute to increased morbidity and mortality. This review describes key pathophysiologic processes in addition to biologic and sociodemographic risk factors that impact observed cardiovascular disparities in racial and ethnic minority populations with chronic kidney disease. The review highlights factors impacting the relationship between chronic kidney disease and cardiovascular risk including diabetes, dyslipidemia, apolipoprotein L1 gene variants, dialysis, and kidney transplantation as well as drivers of racial and ethnic disparities including structural racism.
AB - Purpose of Review: The purpose of this article is to critically appraise and summarize recent literature addressing racial and ethnic disparities in cardiovascular disease among adults with chronic kidney disease. Recent Findings: Despite advances in medical care, individuals with chronic kidney disease continue to bear a high burden of clinical and subclinical cardiovascular disease. Multiple racial and ethnic factors influence cardiovascular disease pathophysiology, burden, and clinical outcomes therein contributing to increased morbidity and mortality among racial and ethnic minority populations with chronic kidney disease. Summary: Racial differences in the prevalence of left ventricular hypertrophy, endothelial dysfunction, vascular calcification, and inflammation are observed in chronic kidney disease and contribute to increased morbidity and mortality. This review describes key pathophysiologic processes in addition to biologic and sociodemographic risk factors that impact observed cardiovascular disparities in racial and ethnic minority populations with chronic kidney disease. The review highlights factors impacting the relationship between chronic kidney disease and cardiovascular risk including diabetes, dyslipidemia, apolipoprotein L1 gene variants, dialysis, and kidney transplantation as well as drivers of racial and ethnic disparities including structural racism.
KW - Cardiovascular disease
KW - Disparities
KW - Ethnicity
KW - Kidney disease
KW - Race
KW - Risk factors
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U2 - 10.1007/s12170-022-00701-2
DO - 10.1007/s12170-022-00701-2
M3 - Review article
AN - SCOPUS:85135069113
SN - 1932-9520
VL - 16
SP - 145
EP - 157
JO - Current Cardiovascular Risk Reports
JF - Current Cardiovascular Risk Reports
IS - 11
ER -