Race and sex-based differences in cytokine immune responses to smallpox vaccine in healthy individuals

Iana H. Haralambieva, Inna G. Ovsyannikova, Richard B Kennedy, Beth R. Larrabee, V. Shane Pankratz, Gregory A. Poland

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

We assessed the effects of sex, race and ethnicity on smallpox vaccine-induced immune responses in 1071 armed forces members after primary Dryvax® smallpox vaccination, including 790 males and 281 females; 580 Caucasians, 217 African-Americans, and 217 Hispanics. Analysis of vaccinia-specific cytokine responses revealed that Caucasians had higher total IFNγ ELISPOT responses (median 57 spot-forming units/SFUs per 200,000 cells, p=0.01) and CD8+IFNγ ELISPOT responses (12 SFUs, p<0.001) than African-Americans (51 and 4 SFUs, respectively) and Hispanics (47 and 8 SFUs, respectively). Similarly, Caucasians secreted higher levels of vaccinia-specific IL-2 (p=0.003) and IFNα (p<0.001) compared to other racial/ethnic groups. Males had higher total IFNγ ELISPOT responses (median 55 SFUs) compared to females (41 SFUs, p<0.001). We observed statistically significant sex-related differences in the secretion of IL-2 (p<0.001), IL-1β (p<0.001) and IL-10 (p=0.017). These data suggest that vaccinia-specific cytokine responses following primary smallpox vaccination are significantly influenced by race and sex of vaccinees.

Original languageEnglish (US)
Pages (from-to)1263-1266
Number of pages4
JournalHuman Immunology
Volume74
Issue number10
DOIs
StatePublished - Oct 2013

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Smallpox Vaccine
Enzyme-Linked Immunospot Assay
Vaccinia
Sex Characteristics
Smallpox
Cytokines
Hispanic Americans
African Americans
Interleukin-2
Vaccination
Interleukin-1
Ethnic Groups
Interleukin-10

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Haralambieva, I. H., Ovsyannikova, I. G., Kennedy, R. B., Larrabee, B. R., Shane Pankratz, V., & Poland, G. A. (2013). Race and sex-based differences in cytokine immune responses to smallpox vaccine in healthy individuals. Human Immunology, 74(10), 1263-1266. https://doi.org/10.1016/j.humimm.2013.06.031

Race and sex-based differences in cytokine immune responses to smallpox vaccine in healthy individuals. / Haralambieva, Iana H.; Ovsyannikova, Inna G.; Kennedy, Richard B; Larrabee, Beth R.; Shane Pankratz, V.; Poland, Gregory A.

In: Human Immunology, Vol. 74, No. 10, 10.2013, p. 1263-1266.

Research output: Contribution to journalArticle

Haralambieva, IH, Ovsyannikova, IG, Kennedy, RB, Larrabee, BR, Shane Pankratz, V & Poland, GA 2013, 'Race and sex-based differences in cytokine immune responses to smallpox vaccine in healthy individuals', Human Immunology, vol. 74, no. 10, pp. 1263-1266. https://doi.org/10.1016/j.humimm.2013.06.031
Haralambieva, Iana H. ; Ovsyannikova, Inna G. ; Kennedy, Richard B ; Larrabee, Beth R. ; Shane Pankratz, V. ; Poland, Gregory A. / Race and sex-based differences in cytokine immune responses to smallpox vaccine in healthy individuals. In: Human Immunology. 2013 ; Vol. 74, No. 10. pp. 1263-1266.
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