TY - JOUR
T1 - Questionnaire based assessment of risk factors for primary biliary cirrhosis
AU - Lammert, Craig
AU - Nguyen, Douglas L.
AU - Juran, Brian D.
AU - Schlicht, Erik
AU - Larson, Joseph J.
AU - Atkinson, Elizabeth J.
AU - Lazaridis, Konstantinos N.
N1 - Funding Information:
This research was supported by grants to Dr. Lazaridis from the NIH ( RO1 DK80670 ) and A.J. and Sigismunda Palumbo Charitable Trust, as well as a grant to Dr. Lammert from the American Liver Foundation.
PY - 2013/7
Y1 - 2013/7
N2 - Background: Primary biliary cirrhosis is a cholestatic liver disease characterized by immune-mediated destruction of bile ducts. Its pathogenesis is largely unknown, although complex interactions between environment and genetic predisposition are proposed. Aims: Identify disease risk factors using a detailed patient questionnaire and compare study findings to 3 published reports. Methods: Questionnaire data were prospectively collected from 522 cases and 616 controls of the Mayo Clinic Primary Biliary Cirrhosis Genetic Epidemiology Registry. Case and control responses were compared using logistic regression, adjusting for recruitment age, sex, and education level. Results: Cases reported ever regularly smoking cigarettes more frequently than controls (P<. 0.001). History of urinary tract infection was similar between groups; however, cases reported multiple urinary tract infections more commonly than controls (P<. 0.001). Frequency of other autoimmune disease was higher in cases than controls (P<. 0.001). As well, prevalence of primary biliary cirrhosis among first-degree relatives was higher in case families than control families (P<. 0.001). Conclusions: Our study confirms prior reported risk factors associated with disease risk. Given the potential importance of gene and environment interactions, further examination of environmental risk factors considering genetic background may provide new insight into primary biliary cirrhosis pathogenesis.
AB - Background: Primary biliary cirrhosis is a cholestatic liver disease characterized by immune-mediated destruction of bile ducts. Its pathogenesis is largely unknown, although complex interactions between environment and genetic predisposition are proposed. Aims: Identify disease risk factors using a detailed patient questionnaire and compare study findings to 3 published reports. Methods: Questionnaire data were prospectively collected from 522 cases and 616 controls of the Mayo Clinic Primary Biliary Cirrhosis Genetic Epidemiology Registry. Case and control responses were compared using logistic regression, adjusting for recruitment age, sex, and education level. Results: Cases reported ever regularly smoking cigarettes more frequently than controls (P<. 0.001). History of urinary tract infection was similar between groups; however, cases reported multiple urinary tract infections more commonly than controls (P<. 0.001). Frequency of other autoimmune disease was higher in cases than controls (P<. 0.001). As well, prevalence of primary biliary cirrhosis among first-degree relatives was higher in case families than control families (P<. 0.001). Conclusions: Our study confirms prior reported risk factors associated with disease risk. Given the potential importance of gene and environment interactions, further examination of environmental risk factors considering genetic background may provide new insight into primary biliary cirrhosis pathogenesis.
KW - Autoimmune
KW - Cholestasis
KW - Tobacco
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U2 - 10.1016/j.dld.2013.01.028
DO - 10.1016/j.dld.2013.01.028
M3 - Article
C2 - 23490343
AN - SCOPUS:84881230563
SN - 1590-8658
VL - 45
SP - 589
EP - 594
JO - Digestive and Liver Disease
JF - Digestive and Liver Disease
IS - 7
ER -