Quercetin enhances pretumorous lesions in the NMU model of rat pancreatic carcinogenesis

Nelso N. Barotto, Cristina B. López, Aldo R. Eynard, Martín E. Fernández Zapico, Mirta A. Valentich

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

The effect of dietary quercetin (Q) was evaluated in rats treated with nitrosomethylurea (NMU). Pancreatic nodules and focal acinar cell hyperplasias were observed in groups treated with NMU (87%) and Q-NMU (100%). Although rats with dysplastic foci (27%) were found in the NMU-treated group, Q-NMU treatment resulted in a significantly higher number of rats with dysplastic foci (73%). Furthermore, carcinomas in situ (12%) and one microcarcinoma (4%) were found in these animals. Mitosis was significantly increased and apoptosis was diminished in focal acinar cell hyperplasias of the Q-NMU group. Our present results support a promoting and progressing effect of quercetin in the NMU model of rat pancreatic carcinogenesis.

Original languageEnglish (US)
Pages (from-to)1-6
Number of pages6
JournalCancer Letters
Volume129
Issue number1
DOIs
StatePublished - Jul 3 1998

Keywords

  • Nitrosomethylurea
  • Pancreatic carcinogenesis
  • Progression
  • Promotion
  • Quercetin

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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