Abstract
The effect of dietary quercetin (Q) was evaluated in rats treated with nitrosomethylurea (NMU). Pancreatic nodules and focal acinar cell hyperplasias were observed in groups treated with NMU (87%) and Q-NMU (100%). Although rats with dysplastic foci (27%) were found in the NMU-treated group, Q-NMU treatment resulted in a significantly higher number of rats with dysplastic foci (73%). Furthermore, carcinomas in situ (12%) and one microcarcinoma (4%) were found in these animals. Mitosis was significantly increased and apoptosis was diminished in focal acinar cell hyperplasias of the Q-NMU group. Our present results support a promoting and progressing effect of quercetin in the NMU model of rat pancreatic carcinogenesis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1-6 |
| Number of pages | 6 |
| Journal | Cancer Letters |
| Volume | 129 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jul 3 1998 |
Keywords
- Nitrosomethylurea
- Pancreatic carcinogenesis
- Progression
- Promotion
- Quercetin
ASJC Scopus subject areas
- Oncology
- Cancer Research
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Barotto, N. N., López, C. B., Eynard, A. R., Fernández Zapico, M. E., & Valentich, M. A. (1998). Quercetin enhances pretumorous lesions in the NMU model of rat pancreatic carcinogenesis. Cancer Letters, 129(1), 1-6. https://doi.org/10.1016/S0304-3835(98)00033-0