Abstract
The effect of dietary quercetin (Q) was evaluated in rats treated with nitrosomethylurea (NMU). Pancreatic nodules and focal acinar cell hyperplasias were observed in groups treated with NMU (87%) and Q-NMU (100%). Although rats with dysplastic foci (27%) were found in the NMU-treated group, Q-NMU treatment resulted in a significantly higher number of rats with dysplastic foci (73%). Furthermore, carcinomas in situ (12%) and one microcarcinoma (4%) were found in these animals. Mitosis was significantly increased and apoptosis was diminished in focal acinar cell hyperplasias of the Q-NMU group. Our present results support a promoting and progressing effect of quercetin in the NMU model of rat pancreatic carcinogenesis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1-6 |
| Number of pages | 6 |
| Journal | Cancer Letters |
| Volume | 129 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jul 3 1998 |
| Externally published | Yes |
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Keywords
- Nitrosomethylurea
- Pancreatic carcinogenesis
- Progression
- Promotion
- Quercetin
ASJC Scopus subject areas
- Cancer Research
- Molecular Biology
- Oncology
Cite this
Quercetin enhances pretumorous lesions in the NMU model of rat pancreatic carcinogenesis. / Barotto, Nelso N.; López, Cristina B.; Eynard, Aldo R.; Fernandez-Zapico, Martin E; Valentich, Mirta A.
In: Cancer Letters, Vol. 129, No. 1, 03.07.1998, p. 1-6.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Quercetin enhances pretumorous lesions in the NMU model of rat pancreatic carcinogenesis
AU - Barotto, Nelso N.
AU - López, Cristina B.
AU - Eynard, Aldo R.
AU - Fernandez-Zapico, Martin E
AU - Valentich, Mirta A.
PY - 1998/7/3
Y1 - 1998/7/3
N2 - The effect of dietary quercetin (Q) was evaluated in rats treated with nitrosomethylurea (NMU). Pancreatic nodules and focal acinar cell hyperplasias were observed in groups treated with NMU (87%) and Q-NMU (100%). Although rats with dysplastic foci (27%) were found in the NMU-treated group, Q-NMU treatment resulted in a significantly higher number of rats with dysplastic foci (73%). Furthermore, carcinomas in situ (12%) and one microcarcinoma (4%) were found in these animals. Mitosis was significantly increased and apoptosis was diminished in focal acinar cell hyperplasias of the Q-NMU group. Our present results support a promoting and progressing effect of quercetin in the NMU model of rat pancreatic carcinogenesis.
AB - The effect of dietary quercetin (Q) was evaluated in rats treated with nitrosomethylurea (NMU). Pancreatic nodules and focal acinar cell hyperplasias were observed in groups treated with NMU (87%) and Q-NMU (100%). Although rats with dysplastic foci (27%) were found in the NMU-treated group, Q-NMU treatment resulted in a significantly higher number of rats with dysplastic foci (73%). Furthermore, carcinomas in situ (12%) and one microcarcinoma (4%) were found in these animals. Mitosis was significantly increased and apoptosis was diminished in focal acinar cell hyperplasias of the Q-NMU group. Our present results support a promoting and progressing effect of quercetin in the NMU model of rat pancreatic carcinogenesis.
KW - Nitrosomethylurea
KW - Pancreatic carcinogenesis
KW - Progression
KW - Promotion
KW - Quercetin
UR - http://www.scopus.com/inward/record.url?scp=0345451003&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0345451003&partnerID=8YFLogxK
U2 - 10.1016/S0304-3835(98)00033-0
DO - 10.1016/S0304-3835(98)00033-0
M3 - Article
C2 - 9714328
AN - SCOPUS:0345451003
VL - 129
SP - 1
EP - 6
JO - Cancer Letters
JF - Cancer Letters
SN - 0304-3835
IS - 1
ER -