Quercetin enhances pretumorous lesions in the NMU model of rat pancreatic carcinogenesis

Nelso N. Barotto, Cristina B. López, Aldo R. Eynard, Martin E Fernandez-Zapico, Mirta A. Valentich

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The effect of dietary quercetin (Q) was evaluated in rats treated with nitrosomethylurea (NMU). Pancreatic nodules and focal acinar cell hyperplasias were observed in groups treated with NMU (87%) and Q-NMU (100%). Although rats with dysplastic foci (27%) were found in the NMU-treated group, Q-NMU treatment resulted in a significantly higher number of rats with dysplastic foci (73%). Furthermore, carcinomas in situ (12%) and one microcarcinoma (4%) were found in these animals. Mitosis was significantly increased and apoptosis was diminished in focal acinar cell hyperplasias of the Q-NMU group. Our present results support a promoting and progressing effect of quercetin in the NMU model of rat pancreatic carcinogenesis.

Original languageEnglish (US)
Pages (from-to)1-6
Number of pages6
JournalCancer Letters
Volume129
Issue number1
DOIs
StatePublished - Jul 3 1998
Externally publishedYes

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Methylnitrosourea
Quercetin
Carcinogenesis
Acinar Cells
Hyperplasia
Carcinoma in Situ
Mitosis
Apoptosis

Keywords

  • Nitrosomethylurea
  • Pancreatic carcinogenesis
  • Progression
  • Promotion
  • Quercetin

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology

Cite this

Quercetin enhances pretumorous lesions in the NMU model of rat pancreatic carcinogenesis. / Barotto, Nelso N.; López, Cristina B.; Eynard, Aldo R.; Fernandez-Zapico, Martin E; Valentich, Mirta A.

In: Cancer Letters, Vol. 129, No. 1, 03.07.1998, p. 1-6.

Research output: Contribution to journalArticle

Barotto, Nelso N. ; López, Cristina B. ; Eynard, Aldo R. ; Fernandez-Zapico, Martin E ; Valentich, Mirta A. / Quercetin enhances pretumorous lesions in the NMU model of rat pancreatic carcinogenesis. In: Cancer Letters. 1998 ; Vol. 129, No. 1. pp. 1-6.
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AU - Valentich, Mirta A.

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