Quercetin enhances pretumorous lesions in the NMU model of rat pancreatic carcinogenesis

Nelso N. Barotto; Cristina B. López; Aldo R. Eynard; Martín E. Fernández Zapico; Mirta A. Valentich

doi:10.1016/S0304-3835(98)00033-0

Quercetin enhances pretumorous lesions in the NMU model of rat pancreatic carcinogenesis

Nelso N. Barotto, Cristina B. López, Aldo R. Eynard, Martín E. Fernández Zapico, Mirta A. Valentich

Oncology

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

The effect of dietary quercetin (Q) was evaluated in rats treated with nitrosomethylurea (NMU). Pancreatic nodules and focal acinar cell hyperplasias were observed in groups treated with NMU (87%) and Q-NMU (100%). Although rats with dysplastic foci (27%) were found in the NMU-treated group, Q-NMU treatment resulted in a significantly higher number of rats with dysplastic foci (73%). Furthermore, carcinomas in situ (12%) and one microcarcinoma (4%) were found in these animals. Mitosis was significantly increased and apoptosis was diminished in focal acinar cell hyperplasias of the Q-NMU group. Our present results support a promoting and progressing effect of quercetin in the NMU model of rat pancreatic carcinogenesis.

Original language	English (US)
Pages (from-to)	1-6
Number of pages	6
Journal	Cancer Letters
Volume	129
Issue number	1
DOIs	https://doi.org/10.1016/S0304-3835(98)00033-0
State	Published - Jul 3 1998

Keywords

Nitrosomethylurea
Pancreatic carcinogenesis
Progression
Promotion
Quercetin

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1016/S0304-3835(98)00033-0

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title = "Quercetin enhances pretumorous lesions in the NMU model of rat pancreatic carcinogenesis",

abstract = "The effect of dietary quercetin (Q) was evaluated in rats treated with nitrosomethylurea (NMU). Pancreatic nodules and focal acinar cell hyperplasias were observed in groups treated with NMU (87%) and Q-NMU (100%). Although rats with dysplastic foci (27%) were found in the NMU-treated group, Q-NMU treatment resulted in a significantly higher number of rats with dysplastic foci (73%). Furthermore, carcinomas in situ (12%) and one microcarcinoma (4%) were found in these animals. Mitosis was significantly increased and apoptosis was diminished in focal acinar cell hyperplasias of the Q-NMU group. Our present results support a promoting and progressing effect of quercetin in the NMU model of rat pancreatic carcinogenesis.",

keywords = "Nitrosomethylurea, Pancreatic carcinogenesis, Progression, Promotion, Quercetin",

author = "Barotto, {Nelso N.} and L{\'o}pez, {Cristina B.} and Eynard, {Aldo R.} and {Fern{\'a}ndez Zapico}, {Mart{\'i}n E.} and Valentich, {Mirta A.}",

note = "Funding Information: The authors thank Dr Martha Gonz{\'a}lez Cremer and Dr Francisco A. Tausk for critical reading of the manuscript, Dr Sonia Mu{\~n}oz for helpful advice in statistical analysis, Jos{\'e} Hiza for animal care, N{\'e}lida Ramonda for technical aid and Luc{\'ı}a Artino for photographic work. We are also indebted to Arcor S.A.I.C. who provided casein for the diet. This work was supported by SECYT-UNC, CONICOR and CONICET, Argentina. Copyright: Copyright 2007 Elsevier B.V., All rights reserved.",

year = "1998",

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doi = "10.1016/S0304-3835(98)00033-0",

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AU - Barotto, Nelso N.

AU - López, Cristina B.

AU - Eynard, Aldo R.

AU - Fernández Zapico, Martín E.

AU - Valentich, Mirta A.

N1 - Funding Information: The authors thank Dr Martha González Cremer and Dr Francisco A. Tausk for critical reading of the manuscript, Dr Sonia Muñoz for helpful advice in statistical analysis, José Hiza for animal care, Nélida Ramonda for technical aid and Lucı́a Artino for photographic work. We are also indebted to Arcor S.A.I.C. who provided casein for the diet. This work was supported by SECYT-UNC, CONICOR and CONICET, Argentina. Copyright: Copyright 2007 Elsevier B.V., All rights reserved.

PY - 1998/7/3

Y1 - 1998/7/3

N2 - The effect of dietary quercetin (Q) was evaluated in rats treated with nitrosomethylurea (NMU). Pancreatic nodules and focal acinar cell hyperplasias were observed in groups treated with NMU (87%) and Q-NMU (100%). Although rats with dysplastic foci (27%) were found in the NMU-treated group, Q-NMU treatment resulted in a significantly higher number of rats with dysplastic foci (73%). Furthermore, carcinomas in situ (12%) and one microcarcinoma (4%) were found in these animals. Mitosis was significantly increased and apoptosis was diminished in focal acinar cell hyperplasias of the Q-NMU group. Our present results support a promoting and progressing effect of quercetin in the NMU model of rat pancreatic carcinogenesis.

AB - The effect of dietary quercetin (Q) was evaluated in rats treated with nitrosomethylurea (NMU). Pancreatic nodules and focal acinar cell hyperplasias were observed in groups treated with NMU (87%) and Q-NMU (100%). Although rats with dysplastic foci (27%) were found in the NMU-treated group, Q-NMU treatment resulted in a significantly higher number of rats with dysplastic foci (73%). Furthermore, carcinomas in situ (12%) and one microcarcinoma (4%) were found in these animals. Mitosis was significantly increased and apoptosis was diminished in focal acinar cell hyperplasias of the Q-NMU group. Our present results support a promoting and progressing effect of quercetin in the NMU model of rat pancreatic carcinogenesis.

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KW - Promotion

KW - Quercetin

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Quercetin enhances pretumorous lesions in the NMU model of rat pancreatic carcinogenesis

Abstract

Keywords

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