Quercetin enhances pretumorous lesions in the NMU model of rat pancreatic carcinogenesis

Nelso N. Barotto; Cristina B. López; Aldo R. Eynard; Martín E. Fernández Zapico; Mirta A. Valentich

doi:10.1016/S0304-3835(98)00033-0

Quercetin enhances pretumorous lesions in the NMU model of rat pancreatic carcinogenesis

Nelso N. Barotto, Cristina B. López, Aldo R. Eynard, Martín E. Fernández Zapico, Mirta A. Valentich

Oncology

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

The effect of dietary quercetin (Q) was evaluated in rats treated with nitrosomethylurea (NMU). Pancreatic nodules and focal acinar cell hyperplasias were observed in groups treated with NMU (87%) and Q-NMU (100%). Although rats with dysplastic foci (27%) were found in the NMU-treated group, Q-NMU treatment resulted in a significantly higher number of rats with dysplastic foci (73%). Furthermore, carcinomas in situ (12%) and one microcarcinoma (4%) were found in these animals. Mitosis was significantly increased and apoptosis was diminished in focal acinar cell hyperplasias of the Q-NMU group. Our present results support a promoting and progressing effect of quercetin in the NMU model of rat pancreatic carcinogenesis.

Original language	English (US)
Pages (from-to)	1-6
Number of pages	6
Journal	Cancer Letters
Volume	129
Issue number	1
DOIs	https://doi.org/10.1016/S0304-3835(98)00033-0
State	Published - Jul 3 1998

Keywords

Nitrosomethylurea
Pancreatic carcinogenesis
Progression
Promotion
Quercetin

ASJC Scopus subject areas

Oncology
Cancer Research

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title = "Quercetin enhances pretumorous lesions in the NMU model of rat pancreatic carcinogenesis",

abstract = "The effect of dietary quercetin (Q) was evaluated in rats treated with nitrosomethylurea (NMU). Pancreatic nodules and focal acinar cell hyperplasias were observed in groups treated with NMU (87%) and Q-NMU (100%). Although rats with dysplastic foci (27%) were found in the NMU-treated group, Q-NMU treatment resulted in a significantly higher number of rats with dysplastic foci (73%). Furthermore, carcinomas in situ (12%) and one microcarcinoma (4%) were found in these animals. Mitosis was significantly increased and apoptosis was diminished in focal acinar cell hyperplasias of the Q-NMU group. Our present results support a promoting and progressing effect of quercetin in the NMU model of rat pancreatic carcinogenesis.",

keywords = "Nitrosomethylurea, Pancreatic carcinogenesis, Progression, Promotion, Quercetin",

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T1 - Quercetin enhances pretumorous lesions in the NMU model of rat pancreatic carcinogenesis

AU - Barotto, Nelso N.

AU - López, Cristina B.

AU - Eynard, Aldo R.

AU - Fernández Zapico, Martín E.

AU - Valentich, Mirta A.

PY - 1998/7/3

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N2 - The effect of dietary quercetin (Q) was evaluated in rats treated with nitrosomethylurea (NMU). Pancreatic nodules and focal acinar cell hyperplasias were observed in groups treated with NMU (87%) and Q-NMU (100%). Although rats with dysplastic foci (27%) were found in the NMU-treated group, Q-NMU treatment resulted in a significantly higher number of rats with dysplastic foci (73%). Furthermore, carcinomas in situ (12%) and one microcarcinoma (4%) were found in these animals. Mitosis was significantly increased and apoptosis was diminished in focal acinar cell hyperplasias of the Q-NMU group. Our present results support a promoting and progressing effect of quercetin in the NMU model of rat pancreatic carcinogenesis.

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