Quantitative stratification of diffuse parenchymal lung diseases

Sushravya Raghunath, Srinivasan Rajagopalan, Ronald A. Karwoski, Fabien Maldonado, Tobias D Peikert, Teng Moua, Jay H Ryu, Brian Jack Bartholmai, Richard A. Robb

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Diffuse parenchymal lung diseases (DPLDs) are characterized by widespread pathological changes within the pulmonary tissue that impair the elasticity and gas exchange properties of the lungs. Clinical-radiological diagnosis of these diseases remains challenging and their clinical course is characterized by variable disease progression. These challenges have hindered the introduction of robust objective biomarkers for patient-specific prediction based on specific phenotypes in clinical practice for patients with DPLD. Therefore, strategies facilitating individualized clinical management, staging and identification of specific phenotypes linked to clinical disease outcomes or therapeutic responses are urgently needed. A classification schema consistently reflecting the radiological, clinical (lung function and clinical outcomes) and pathological features of a disease represents a critical need in modern pulmonary medicine. Herein, we report a quantitative stratification paradigm to identify subsets of DPLD patients with characteristic radiologic patterns in an unsupervised manner and demonstrate significant correlation of these self-organized disease groups with clinically accepted surrogate endpoints. The proposed consistent and reproducible technique could potentially transform diagnostic staging, clinical management and prognostication of DPLD patients as well as facilitate patient selection for clinical trials beyond the ability of current radiological tools. In addition, the sequential quantitative stratification of the type and extent of parenchymal process may allow standardized and objective monitoring of disease, early assessment of treatment response and mortality prediction for DPLD patients.

Original languageEnglish (US)
Article numbere93229
JournalPLoS One
Volume9
Issue number3
DOIs
StatePublished - Mar 27 2014

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Pulmonary diseases
Interstitial Lung Diseases
respiratory tract diseases
Lung
lungs
disease course
Biomarkers
Phenotype
pulmonary gas exchange
Pulmonary Medicine
Modern 1601-history
Elasticity
phenotype
prediction
disease surveillance
lung function
Patient Selection
disease diagnosis
Disease Progression
elasticity (mechanics)

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Raghunath, S., Rajagopalan, S., Karwoski, R. A., Maldonado, F., Peikert, T. D., Moua, T., ... Robb, R. A. (2014). Quantitative stratification of diffuse parenchymal lung diseases. PLoS One, 9(3), [e93229]. https://doi.org/10.1371/journal.pone.0093229

Quantitative stratification of diffuse parenchymal lung diseases. / Raghunath, Sushravya; Rajagopalan, Srinivasan; Karwoski, Ronald A.; Maldonado, Fabien; Peikert, Tobias D; Moua, Teng; Ryu, Jay H; Bartholmai, Brian Jack; Robb, Richard A.

In: PLoS One, Vol. 9, No. 3, e93229, 27.03.2014.

Research output: Contribution to journalArticle

Raghunath, S, Rajagopalan, S, Karwoski, RA, Maldonado, F, Peikert, TD, Moua, T, Ryu, JH, Bartholmai, BJ & Robb, RA 2014, 'Quantitative stratification of diffuse parenchymal lung diseases', PLoS One, vol. 9, no. 3, e93229. https://doi.org/10.1371/journal.pone.0093229
Raghunath S, Rajagopalan S, Karwoski RA, Maldonado F, Peikert TD, Moua T et al. Quantitative stratification of diffuse parenchymal lung diseases. PLoS One. 2014 Mar 27;9(3). e93229. https://doi.org/10.1371/journal.pone.0093229
Raghunath, Sushravya ; Rajagopalan, Srinivasan ; Karwoski, Ronald A. ; Maldonado, Fabien ; Peikert, Tobias D ; Moua, Teng ; Ryu, Jay H ; Bartholmai, Brian Jack ; Robb, Richard A. / Quantitative stratification of diffuse parenchymal lung diseases. In: PLoS One. 2014 ; Vol. 9, No. 3.
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