@article{53009c4dd9cb4ee39662b3ed2b282a22,
title = "Quantitative PCR-based screening of α-synuclein multiplication in multiple system atrophy",
abstract = "Multiple system atrophy (MSA) is by nature a 'sporadic' disease with no evidence of familial aggregation observed. However, the α-synuclein locus (SNCA) multiplication families have clinically displayed parkinsonism and autonomic dysfunction. The present study did not find any SNCA multiplications in a series of 58 pathologically confirmed MSA cases excluding this event as a common cause of MSA. The question of a genetic component in MSA remains to be answered.",
keywords = "Genomic multiplication, Multiple system atrophy, Quantitative PCR, α-Synuclein",
author = "Lincoln, {Sarah J.} and Ross, {Owen A.} and Milkovic, {Nicole M.} and Dickson, {Dennis W.} and Alex Rajput and Robinson, {Christopher A.} and Spiridon Papapetropoulos and Mash, {Deborah C.} and Farrer, {Matthew J.}",
note = "Funding Information: Mayo Clinic Jacksonville is a Morris K. Udall Parkinson's Disease Research Center of Excellence (NINDS P50 #NS40256). We are grateful to the Parkinson Society Canada. The Brain Endowment Bank sponsored in part by the NPF Inc. (Miami, FL 33136, USA). We thank Minnie Schreiber for technical assistance. We would like to thank all those who have contributed to our research, particularly the patients and their families.",
year = "2007",
month = aug,
doi = "10.1016/j.parkreldis.2006.12.005",
language = "English (US)",
volume = "13",
pages = "340--342",
journal = "Parkinsonism and Related Disorders",
issn = "1353-8020",
publisher = "Elsevier BV",
number = "6",
}