Abstract
Neurofibrillary tangles (NFTs) are one of the key histological lesions of Alzheimer's disease (AD) and are associated with brain atrophy. We assessed regional NFT density in 30 patients with AD, 10 of which presented as the logopenic variant of primary progressive aphasia (lvPPA) and 20 that presented as dementia of the Alzheimer's type (DAT). Regional grey matter volumes were measured using antemortem MRI. NFT density was significantly higher in left temporoparietal cortices in lvPPA compared to DAT, with no differences observed in hippocampus. There was a trend for the ratio of temporoparietal-to-hippocampal NFT density to be higher in lvPPA. The imaging findings mirrored the pathological findings, with smaller left temporoparietal volumes observed in lvPPA compared to DAT, and no differences observed in hippocampal volume. This study demonstrates that lvPPA is associated with a phenomenon of enhanced temporoparietal neurodegeneration, a finding that improves our understanding of the biological basis of lvPPA.
Original language | English (US) |
---|---|
Pages (from-to) | 127-134 |
Number of pages | 8 |
Journal | Brain and Language |
Volume | 127 |
Issue number | 2 |
DOIs | |
State | Published - Nov 2013 |
Keywords
- Alzheimer's dementia
- Alzheimer's disease
- Apolipoprotein E
- Hippocampus
- Logopenic variant of primary progressive aphasia
- MRI
- Neurofibrillary tangles
- Primary progressive aphasia
- TDP-43
- Voxel-based morphometry
ASJC Scopus subject areas
- Experimental and Cognitive Psychology
- Language and Linguistics
- Linguistics and Language
- Cognitive Neuroscience
- Speech and Hearing