Abstract
Neurofibrillary tangles (NFTs) are one of the key histological lesions of Alzheimer's disease (AD) and are associated with brain atrophy. We assessed regional NFT density in 30 patients with AD, 10 of which presented as the logopenic variant of primary progressive aphasia (lvPPA) and 20 that presented as dementia of the Alzheimer's type (DAT). Regional grey matter volumes were measured using antemortem MRI. NFT density was significantly higher in left temporoparietal cortices in lvPPA compared to DAT, with no differences observed in hippocampus. There was a trend for the ratio of temporoparietal-to-hippocampal NFT density to be higher in lvPPA. The imaging findings mirrored the pathological findings, with smaller left temporoparietal volumes observed in lvPPA compared to DAT, and no differences observed in hippocampal volume. This study demonstrates that lvPPA is associated with a phenomenon of enhanced temporoparietal neurodegeneration, a finding that improves our understanding of the biological basis of lvPPA.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 127-134 |
| Number of pages | 8 |
| Journal | Brain and Language |
| Volume | 127 |
| Issue number | 2 |
| DOIs | |
| State | Published - Nov 2013 |
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Keywords
- Alzheimer's dementia
- Alzheimer's disease
- Apolipoprotein E
- Hippocampus
- Logopenic variant of primary progressive aphasia
- MRI
- Neurofibrillary tangles
- Primary progressive aphasia
- TDP-43
- Voxel-based morphometry
ASJC Scopus subject areas
- Linguistics and Language
- Speech and Hearing
- Experimental and Cognitive Psychology
- Cognitive Neuroscience
- Language and Linguistics
Cite this
Quantitative neurofibrillary tangle density and brain volumetric MRI analyses in Alzheimer's disease presenting as logopenic progressive aphasia. / Josephs, Keith Anthony; Dickson, Dennis W; Murray, Melissa E; Senjem, Matthew L.; Parisi, Joseph E; Petersen, Ronald Carl; Jack, Clifford R Jr.; Whitwell, Jennifer Lynn.
In: Brain and Language, Vol. 127, No. 2, 11.2013, p. 127-134.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Quantitative neurofibrillary tangle density and brain volumetric MRI analyses in Alzheimer's disease presenting as logopenic progressive aphasia
AU - Josephs, Keith Anthony
AU - Dickson, Dennis W
AU - Murray, Melissa E
AU - Senjem, Matthew L.
AU - Parisi, Joseph E
AU - Petersen, Ronald Carl
AU - Jack, Clifford R Jr.
AU - Whitwell, Jennifer Lynn
PY - 2013/11
Y1 - 2013/11
N2 - Neurofibrillary tangles (NFTs) are one of the key histological lesions of Alzheimer's disease (AD) and are associated with brain atrophy. We assessed regional NFT density in 30 patients with AD, 10 of which presented as the logopenic variant of primary progressive aphasia (lvPPA) and 20 that presented as dementia of the Alzheimer's type (DAT). Regional grey matter volumes were measured using antemortem MRI. NFT density was significantly higher in left temporoparietal cortices in lvPPA compared to DAT, with no differences observed in hippocampus. There was a trend for the ratio of temporoparietal-to-hippocampal NFT density to be higher in lvPPA. The imaging findings mirrored the pathological findings, with smaller left temporoparietal volumes observed in lvPPA compared to DAT, and no differences observed in hippocampal volume. This study demonstrates that lvPPA is associated with a phenomenon of enhanced temporoparietal neurodegeneration, a finding that improves our understanding of the biological basis of lvPPA.
AB - Neurofibrillary tangles (NFTs) are one of the key histological lesions of Alzheimer's disease (AD) and are associated with brain atrophy. We assessed regional NFT density in 30 patients with AD, 10 of which presented as the logopenic variant of primary progressive aphasia (lvPPA) and 20 that presented as dementia of the Alzheimer's type (DAT). Regional grey matter volumes were measured using antemortem MRI. NFT density was significantly higher in left temporoparietal cortices in lvPPA compared to DAT, with no differences observed in hippocampus. There was a trend for the ratio of temporoparietal-to-hippocampal NFT density to be higher in lvPPA. The imaging findings mirrored the pathological findings, with smaller left temporoparietal volumes observed in lvPPA compared to DAT, and no differences observed in hippocampal volume. This study demonstrates that lvPPA is associated with a phenomenon of enhanced temporoparietal neurodegeneration, a finding that improves our understanding of the biological basis of lvPPA.
KW - Alzheimer's dementia
KW - Alzheimer's disease
KW - Apolipoprotein E
KW - Hippocampus
KW - Logopenic variant of primary progressive aphasia
KW - MRI
KW - Neurofibrillary tangles
KW - Primary progressive aphasia
KW - TDP-43
KW - Voxel-based morphometry
UR - http://www.scopus.com/inward/record.url?scp=84888072687&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84888072687&partnerID=8YFLogxK
U2 - 10.1016/j.bandl.2013.02.003
DO - 10.1016/j.bandl.2013.02.003
M3 - Article
C2 - 23541297
AN - SCOPUS:84888072687
VL - 127
SP - 127
EP - 134
JO - Brain and Language
JF - Brain and Language
SN - 0093-934X
IS - 2
ER -