Quantitative MRI hippocampal volumes: association with onset and duration of epilepsy, and febrile convulsions in temporal lobectomy patients

Max R. Trenerry, Clifford R Jr. Jack, Frank W. Sharbrough, Gregory D Cascino, Kathryn A. Hirschorn, W. Richard Marsh, Patrick J. Kelly, Fredric B. Meyer

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Abstract

The relationships between preoperatively acquired MRI-based hippocampal volumes (HV), seizure disorder onset and duration, and early childhood febrile convulsions were investigated retrospectively with data from 72 left and 56 right temporal lobectomy patients. Patients with lesional pathology and heterotopic abnormalities were excluded. Age at development of spontaneous seizures unprovoked by an acute illness defined age of seizure disorder onset. Age of onset was subtracted from age at neurosurgery to determine duration. MRI variables included in this study were the right and left HV divided by total intracranial volume (RAHV, LAHV), and the right - left hippocampal difference (DHF). Partial correlations were used to better isolate relationships with onset of recurrent seizures corrected for age at surgery, and age at neurosurgery corrected for age of recurrent seizure onset. Partial correlations between age at neurosurgery and volume were not significant in either group. LAHV (r = 0.42, P <0.0003) and DHF (r = -0.49, P <0.0001) were correlated with age of onset in the left lobectomy group. Correlations in the right lobectomy group were not significant. The presence of a febrile convulsion was associated with smaller LAHV (F(1,70) = 10.54, P <0.002) and larger DHF (F(1,70) = 11.36, P <0.002) in left temporal lobectomy patients. The presence of a febrile convulsion in the right temporal group was associated with a slightly smaller DHF (F(1,56) = 5.90, P <0.02), and slightly smaller RAHV (F(l,56) = 4.49, P < 0.04). These data suggest that hippocampal atrophy remains stable over the duration of temporal lobe onset seizure disorders, and is associated with early onset of recurrent seizures in left temporal patients. The difference across lobectomy groups in the magnitude of effect with regard to presence of a febrile convulsion, and the lack of correlation between hippocampal atrophy and onset of recurrent seizures in the right lobectomy group may be due to the interaction of developmental differences in brain morphology and timing of the insult that produces hippocampal pathology.

Original languageEnglish (US)
Pages (from-to)247-252
Number of pages6
JournalEpilepsy Research
Volume15
Issue number3
DOIs
StatePublished - 1993

Fingerprint

Febrile Seizures
Epilepsy
Seizures
Neurosurgery
Age of Onset
Atrophy
Pathology
Temporal Lobe
Brain

Keywords

  • Febrile convulsions
  • Hippocampal volumes
  • Magnetic resonance imaging
  • Mesial temporal sclerosis
  • Temporal lobectomy

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Neurology

Cite this

Quantitative MRI hippocampal volumes : association with onset and duration of epilepsy, and febrile convulsions in temporal lobectomy patients. / Trenerry, Max R.; Jack, Clifford R Jr.; Sharbrough, Frank W.; Cascino, Gregory D; Hirschorn, Kathryn A.; Marsh, W. Richard; Kelly, Patrick J.; Meyer, Fredric B.

In: Epilepsy Research, Vol. 15, No. 3, 1993, p. 247-252.

Research output: Contribution to journalArticle

Trenerry, Max R. ; Jack, Clifford R Jr. ; Sharbrough, Frank W. ; Cascino, Gregory D ; Hirschorn, Kathryn A. ; Marsh, W. Richard ; Kelly, Patrick J. ; Meyer, Fredric B. / Quantitative MRI hippocampal volumes : association with onset and duration of epilepsy, and febrile convulsions in temporal lobectomy patients. In: Epilepsy Research. 1993 ; Vol. 15, No. 3. pp. 247-252.
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