Quantitative MRI analysis in children with multiple sclerosis

A multicenter feasibility pilot study

Tanuja Chitnis, Charles R. Guttmann, Alexander Zaitsev, Alexander Musallam, Bianca Weinstock-Guttmann, Ann Yeh, Moses Rodriguez, Jayne Ness, Mark P. Gorman, Brian C. Healy, Nancy Kuntz, Dorothee Chabas, Jonathan B. Strober, Emmanuelle Waubant, Lauren Krupp, Daniel Pelletier, Bradley J Erickson, Niels Bergsland, Robert Zivadinov

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: Pediatric multiple sclerosis (MS) is a rare disorder with significant consequences. Quantitative MRI measurements may provide significant insights, however multicenter collaborative studies are needed given the small numbers of subjects. The goal of this study is to demonstrate feasibility and evaluate lesion volume (LV) characteristics in a multicenter cohort of children with MS. Methods: A common MRI-scanning guideline was implemented at six member sites of the U.S. Network of Pediatric MS Centers of Excellence. We included in this study the first ten scans performed at each site on patients meeting the following inclusion criteria: pediatric RRMS within 3 years of disease onset, examination within 1 month of MRI and no steroids 1 month prior to MRI. We quantified T2 number, T2-LV and individual lesion size in a total of 53 MRIs passing quality control procedures and assessed gadolinium-enhancing lesion number and LV in 55 scans. We studied MRI measures according to demographic features including age, race, ethnicity and disability scores, controlling for disease duration and treatment duration using negative binomial regression and linear regression. Results: The mean number of T2 lesions was 24.30 ± 19.68 (range:1-113) and mean gadolinium-enhancing lesion count was 1.85 ± 5.84, (range:0-32). Individual lesion size ranged from 14.31 to 55750.60 mm3. Non-white subjects had higher T2-LV (unadjusted pT2-LV = 0.028; adjusted pT2-LV = 0.044), and maximal individual T2-LV (unadjusted pMax = 0.007; adjusted pMax = 0.011) than white patients. We also found a trend toward larger mean lesion size in males than females (p = 0.07).Conclusion: Assessment of MRI lesion LV characteristics is feasible in a multicenter cohort of children with MS.

Original languageEnglish (US)
Article number173
JournalBMC Neurology
Volume13
DOIs
StatePublished - Nov 13 2013

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Feasibility Studies
Multiple Sclerosis
Gadolinium
Pediatrics
Quality Control
Multicenter Studies
Linear Models
Steroids
Demography
Guidelines
Therapeutics

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Chitnis, T., Guttmann, C. R., Zaitsev, A., Musallam, A., Weinstock-Guttmann, B., Yeh, A., ... Zivadinov, R. (2013). Quantitative MRI analysis in children with multiple sclerosis: A multicenter feasibility pilot study. BMC Neurology, 13, [173]. https://doi.org/10.1186/1471-2377-13-173

Quantitative MRI analysis in children with multiple sclerosis : A multicenter feasibility pilot study. / Chitnis, Tanuja; Guttmann, Charles R.; Zaitsev, Alexander; Musallam, Alexander; Weinstock-Guttmann, Bianca; Yeh, Ann; Rodriguez, Moses; Ness, Jayne; Gorman, Mark P.; Healy, Brian C.; Kuntz, Nancy; Chabas, Dorothee; Strober, Jonathan B.; Waubant, Emmanuelle; Krupp, Lauren; Pelletier, Daniel; Erickson, Bradley J; Bergsland, Niels; Zivadinov, Robert.

In: BMC Neurology, Vol. 13, 173, 13.11.2013.

Research output: Contribution to journalArticle

Chitnis, T, Guttmann, CR, Zaitsev, A, Musallam, A, Weinstock-Guttmann, B, Yeh, A, Rodriguez, M, Ness, J, Gorman, MP, Healy, BC, Kuntz, N, Chabas, D, Strober, JB, Waubant, E, Krupp, L, Pelletier, D, Erickson, BJ, Bergsland, N & Zivadinov, R 2013, 'Quantitative MRI analysis in children with multiple sclerosis: A multicenter feasibility pilot study', BMC Neurology, vol. 13, 173. https://doi.org/10.1186/1471-2377-13-173
Chitnis T, Guttmann CR, Zaitsev A, Musallam A, Weinstock-Guttmann B, Yeh A et al. Quantitative MRI analysis in children with multiple sclerosis: A multicenter feasibility pilot study. BMC Neurology. 2013 Nov 13;13. 173. https://doi.org/10.1186/1471-2377-13-173
Chitnis, Tanuja ; Guttmann, Charles R. ; Zaitsev, Alexander ; Musallam, Alexander ; Weinstock-Guttmann, Bianca ; Yeh, Ann ; Rodriguez, Moses ; Ness, Jayne ; Gorman, Mark P. ; Healy, Brian C. ; Kuntz, Nancy ; Chabas, Dorothee ; Strober, Jonathan B. ; Waubant, Emmanuelle ; Krupp, Lauren ; Pelletier, Daniel ; Erickson, Bradley J ; Bergsland, Niels ; Zivadinov, Robert. / Quantitative MRI analysis in children with multiple sclerosis : A multicenter feasibility pilot study. In: BMC Neurology. 2013 ; Vol. 13.
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abstract = "Background: Pediatric multiple sclerosis (MS) is a rare disorder with significant consequences. Quantitative MRI measurements may provide significant insights, however multicenter collaborative studies are needed given the small numbers of subjects. The goal of this study is to demonstrate feasibility and evaluate lesion volume (LV) characteristics in a multicenter cohort of children with MS. Methods: A common MRI-scanning guideline was implemented at six member sites of the U.S. Network of Pediatric MS Centers of Excellence. We included in this study the first ten scans performed at each site on patients meeting the following inclusion criteria: pediatric RRMS within 3 years of disease onset, examination within 1 month of MRI and no steroids 1 month prior to MRI. We quantified T2 number, T2-LV and individual lesion size in a total of 53 MRIs passing quality control procedures and assessed gadolinium-enhancing lesion number and LV in 55 scans. We studied MRI measures according to demographic features including age, race, ethnicity and disability scores, controlling for disease duration and treatment duration using negative binomial regression and linear regression. Results: The mean number of T2 lesions was 24.30 ± 19.68 (range:1-113) and mean gadolinium-enhancing lesion count was 1.85 ± 5.84, (range:0-32). Individual lesion size ranged from 14.31 to 55750.60 mm3. Non-white subjects had higher T2-LV (unadjusted pT2-LV = 0.028; adjusted pT2-LV = 0.044), and maximal individual T2-LV (unadjusted pMax = 0.007; adjusted pMax = 0.011) than white patients. We also found a trend toward larger mean lesion size in males than females (p = 0.07).Conclusion: Assessment of MRI lesion LV characteristics is feasible in a multicenter cohort of children with MS.",
author = "Tanuja Chitnis and Guttmann, {Charles R.} and Alexander Zaitsev and Alexander Musallam and Bianca Weinstock-Guttmann and Ann Yeh and Moses Rodriguez and Jayne Ness and Gorman, {Mark P.} and Healy, {Brian C.} and Nancy Kuntz and Dorothee Chabas and Strober, {Jonathan B.} and Emmanuelle Waubant and Lauren Krupp and Daniel Pelletier and Erickson, {Bradley J} and Niels Bergsland and Robert Zivadinov",
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AU - Chitnis, Tanuja

AU - Guttmann, Charles R.

AU - Zaitsev, Alexander

AU - Musallam, Alexander

AU - Weinstock-Guttmann, Bianca

AU - Yeh, Ann

AU - Rodriguez, Moses

AU - Ness, Jayne

AU - Gorman, Mark P.

AU - Healy, Brian C.

AU - Kuntz, Nancy

AU - Chabas, Dorothee

AU - Strober, Jonathan B.

AU - Waubant, Emmanuelle

AU - Krupp, Lauren

AU - Pelletier, Daniel

AU - Erickson, Bradley J

AU - Bergsland, Niels

AU - Zivadinov, Robert

PY - 2013/11/13

Y1 - 2013/11/13

N2 - Background: Pediatric multiple sclerosis (MS) is a rare disorder with significant consequences. Quantitative MRI measurements may provide significant insights, however multicenter collaborative studies are needed given the small numbers of subjects. The goal of this study is to demonstrate feasibility and evaluate lesion volume (LV) characteristics in a multicenter cohort of children with MS. Methods: A common MRI-scanning guideline was implemented at six member sites of the U.S. Network of Pediatric MS Centers of Excellence. We included in this study the first ten scans performed at each site on patients meeting the following inclusion criteria: pediatric RRMS within 3 years of disease onset, examination within 1 month of MRI and no steroids 1 month prior to MRI. We quantified T2 number, T2-LV and individual lesion size in a total of 53 MRIs passing quality control procedures and assessed gadolinium-enhancing lesion number and LV in 55 scans. We studied MRI measures according to demographic features including age, race, ethnicity and disability scores, controlling for disease duration and treatment duration using negative binomial regression and linear regression. Results: The mean number of T2 lesions was 24.30 ± 19.68 (range:1-113) and mean gadolinium-enhancing lesion count was 1.85 ± 5.84, (range:0-32). Individual lesion size ranged from 14.31 to 55750.60 mm3. Non-white subjects had higher T2-LV (unadjusted pT2-LV = 0.028; adjusted pT2-LV = 0.044), and maximal individual T2-LV (unadjusted pMax = 0.007; adjusted pMax = 0.011) than white patients. We also found a trend toward larger mean lesion size in males than females (p = 0.07).Conclusion: Assessment of MRI lesion LV characteristics is feasible in a multicenter cohort of children with MS.

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