Quantitative estimation of insulin sensitivity in type 1 diabetic subjects wearing a sensor-augmented insulin pump

Michele Schiavon, Chiara Dalla Man, Yogish C Kudva, Ananda Basu, Claudio Cobelli

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

OBJECTIVE: The goal was to develop a new index of insulin sensitivity in patients with type 1 diabetes estimated from continuous glucose monitoring (CGM) and subcutaneous insulin delivery data under carefully controlled conditions. RESEARCH DESIGN AND METHODS: The database consists of 12 subjects with type 1 diabetes, studied during breakfast, lunch, and dinner, in a clinical research unit, wearing both subcutaneous insulin pump and CGM device. Frequent blood samples were drawn for measurements of plasma glucose and insulin concentrations in order to estimate insulin sensitivity with the oral minimal model (S I MM). The new index of insulin sensitivity (S I SP) was calculated with a simple algebraic formula for each meal, using only CGM and insulin pump data and compared with S I MM. RESULTS: SI SP was well correlated with SI MM (r = 0.825; P < 10-8), and diurnal pattern was also similar to SI MM. CONCLUSIONS: A novel method for estimating insulin sensitivity in subjects with type 1 diabetes on sensor-augmented insulin pump therapy has been presented. This new index correlates well with the reference oral minimal model estimate of insulin sensitivity. The knowledge of patient-specific insulin sensitivity and its diurnal variation can help in optimizing insulin therapy in type 1 diabetes and could also inform next-generation closed-loop control systems.

Original languageEnglish (US)
Pages (from-to)1216-1223
Number of pages8
JournalDiabetes Care
Volume37
Issue number5
DOIs
StatePublished - 2014

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Insulin Resistance
Insulin
Type 1 Diabetes Mellitus
Glucose
Meals
Lunch
Breakfast
Research Design
Databases
Equipment and Supplies
Therapeutics
Research

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialized Nursing

Cite this

Quantitative estimation of insulin sensitivity in type 1 diabetic subjects wearing a sensor-augmented insulin pump. / Schiavon, Michele; Dalla Man, Chiara; Kudva, Yogish C; Basu, Ananda; Cobelli, Claudio.

In: Diabetes Care, Vol. 37, No. 5, 2014, p. 1216-1223.

Research output: Contribution to journalArticle

Schiavon, Michele ; Dalla Man, Chiara ; Kudva, Yogish C ; Basu, Ananda ; Cobelli, Claudio. / Quantitative estimation of insulin sensitivity in type 1 diabetic subjects wearing a sensor-augmented insulin pump. In: Diabetes Care. 2014 ; Vol. 37, No. 5. pp. 1216-1223.
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