TY - JOUR
T1 - Quantitative doppler assessment of valvular regurgitation
AU - Enriquez-Sarano, Maurice
AU - Bailey, Kent R.
AU - Seward, James B.
AU - Tajik, A. Jamil
AU - Krohn, Mary J.
AU - Mays, Janel M.
N1 - Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 1993/3
Y1 - 1993/3
N2 - Background. Quantitation of valvular regurgitation remains a challenge. The accuracy of quantitative Doppler is controversial, and its ability to measure regurgitant volume is unknown; therefore, it is not widely used. Methods and Results. In 120 patients (20 without regurgitation, 19 with aortic regurgitation, and 81 with mitral regurgitation), the stroke volume through the mitral annulus and left ventricular outflow tract were measured using pulsed-wave Doppler concurrently with left ventricular stroke volume calculated using left ventricular volumes measured by two-dimensional echocardiography Simpson's biapical method. Regurgitant volume and fraction were thus computed using Doppler or ventricular methods. In normal patients there were good correlations between Doppler and left ventricular measurements of stroke volume. Doppler regurgitant volume and fraction were 4.4±4.4 mL and 5.3±4.5%, respectively. In patients with aortic regurgitation, there were good correlations between Doppler and left ventricular measurements of stroke volume, regurgitant volume, and regurgitant fraction (r=0.97, r=0.95, and r=0.93, respectively; p<0.0001). In patients with mitral regurgitation, despite good correlations between Doppler and ventricular methods for stroke volume, regurgitant volume, and regurgitant fraction (r=0.94, r=0.93, and r=0.94, respectively; p<0.001), these variables were overestimated by Doppler. However, in the last 54 patients compared with the first 27, overestimation decreased significantly for regurgitant volume (5±10 mL versus 18±27 mL, p<0.05) and regurgitant fraction (3.3±6.7% versus 6.2±6.8%, p=0.05). Conclusions. Quantitative Doppler can be performed in large numbers of patients in a clinical laboratory. Its potential limitation was identified as overestimation of mitral regurgitation, which is overcome with increased experience. Its achieved accuracy in mitral and aortic regurgitation allows measurement not only of regurgitant fraction but most importantly of regurgitant volume.
AB - Background. Quantitation of valvular regurgitation remains a challenge. The accuracy of quantitative Doppler is controversial, and its ability to measure regurgitant volume is unknown; therefore, it is not widely used. Methods and Results. In 120 patients (20 without regurgitation, 19 with aortic regurgitation, and 81 with mitral regurgitation), the stroke volume through the mitral annulus and left ventricular outflow tract were measured using pulsed-wave Doppler concurrently with left ventricular stroke volume calculated using left ventricular volumes measured by two-dimensional echocardiography Simpson's biapical method. Regurgitant volume and fraction were thus computed using Doppler or ventricular methods. In normal patients there were good correlations between Doppler and left ventricular measurements of stroke volume. Doppler regurgitant volume and fraction were 4.4±4.4 mL and 5.3±4.5%, respectively. In patients with aortic regurgitation, there were good correlations between Doppler and left ventricular measurements of stroke volume, regurgitant volume, and regurgitant fraction (r=0.97, r=0.95, and r=0.93, respectively; p<0.0001). In patients with mitral regurgitation, despite good correlations between Doppler and ventricular methods for stroke volume, regurgitant volume, and regurgitant fraction (r=0.94, r=0.93, and r=0.94, respectively; p<0.001), these variables were overestimated by Doppler. However, in the last 54 patients compared with the first 27, overestimation decreased significantly for regurgitant volume (5±10 mL versus 18±27 mL, p<0.05) and regurgitant fraction (3.3±6.7% versus 6.2±6.8%, p=0.05). Conclusions. Quantitative Doppler can be performed in large numbers of patients in a clinical laboratory. Its potential limitation was identified as overestimation of mitral regurgitation, which is overcome with increased experience. Its achieved accuracy in mitral and aortic regurgitation allows measurement not only of regurgitant fraction but most importantly of regurgitant volume.
KW - Aortic regurgitation
KW - Echocardiographic left ventricular volume
KW - Mitral regurgitation
KW - Regurgitant fraction
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U2 - 10.1161/01.cir.87.3.841
DO - 10.1161/01.cir.87.3.841
M3 - Article
C2 - 8443904
AN - SCOPUS:0027411045
VL - 87
SP - 841
EP - 848
JO - Circulation
JF - Circulation
SN - 0009-7322
IS - 3
ER -