@inproceedings{3829ab972fcc4c05b930bf0df562390a,
title = "Quantitative characterization of brain β-amyloid in 718 normal subjects using a joint PiB/FDG PET image histogram",
abstract = "We have previously described an automated system for the co-registration of PiB and FDG PET images with structural MRI and a neurological anatomy atlas to produce region-specific quantization of cortical activity and amyloid burden. We also reported a global joint PiB/FDG histogram-based measure (FDG-Associated PiB Uptake Ratio - FAPUR) that performed as well as regional PiB ratio in stratifying Alzheimer's disease (AD) and Lewy Body Dementia (LBD) patients from normal subjects in an autopsy-verified cohort of 31. In this paper we examine results of this analysis on a clinically-verified cohort of 718 normal volunteers. We found that the global FDG ratio correlated negatively with age (r2 = 0.044) and global PiB ratio correlated positively with age (r2=0.038). FAPUR also correlated negatively with age (r2-.025), and in addition, we introduce a new metric - the Pearson's correlation coefficient (r2) of the joint PiB/FDG histogram which correlates positively (r2=0.014) with age. We then used these measurements to construct age-weighted Z-scores for all measurements made on the original autopsy cohort. We found similar stratification using Z-scores compared to raw values; however, the joint PiB/FDG r2 Z-score showed the greatest stratification ability.",
keywords = "Alzheimer's disease, Joint histogram, Lewy body disease, PET imaging, PiB, β-amyloid plaques",
author = "Camp, {Jon J.} and Hanson, {Dennis P.} and Lowe, {Val J.} and Kemp, {Bradley J.} and Senjem, {Matthew L.} and Murray, {Melissa E.} and Dickson, {Dennis W.} and Parisi, {Joseph E.} and Petersen, {Ronald C.} and Robb, {Richard A.} and Holmes, {David R.}",
note = "Publisher Copyright: {\textcopyright} 2016 SPIE.; Medical Imaging 2016: Computer-Aided Diagnosis ; Conference date: 28-02-2016 Through 02-03-2016",
year = "2016",
doi = "10.1117/12.2217674",
language = "English (US)",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
publisher = "SPIE",
editor = "Tourassi, {Georgia D.} and Armato, {Samuel G.}",
booktitle = "Medical Imaging 2016",
}