Quantitative characterization of brain β-amyloid in 718 normal subjects using a joint PiB/FDG PET image histogram

Jon J. Camp, Dennis P. Hanson, Val Lowe, Bradley J. Kemp, Matthew L. Senjem, Melissa E Murray, Dennis W Dickson, Joseph E Parisi, Ronald Carl Petersen, Richard A. Robb, David R. Holmes III

Research output: Chapter in Book/Report/Conference proceedingConference contribution


We have previously described an automated system for the co-registration of PiB and FDG PET images with structural MRI and a neurological anatomy atlas to produce region-specific quantization of cortical activity and amyloid burden. We also reported a global joint PiB/FDG histogram-based measure (FDG-Associated PiB Uptake Ratio - FAPUR) that performed as well as regional PiB ratio in stratifying Alzheimer's disease (AD) and Lewy Body Dementia (LBD) patients from normal subjects in an autopsy-verified cohort of 31. In this paper we examine results of this analysis on a clinically-verified cohort of 718 normal volunteers. We found that the global FDG ratio correlated negatively with age (r2 = 0.044) and global PiB ratio correlated positively with age (r2=0.038). FAPUR also correlated negatively with age (r2-.025), and in addition, we introduce a new metric - the Pearson's correlation coefficient (r2) of the joint PiB/FDG histogram which correlates positively (r2=0.014) with age. We then used these measurements to construct age-weighted Z-scores for all measurements made on the original autopsy cohort. We found similar stratification using Z-scores compared to raw values; however, the joint PiB/FDG r2 Z-score showed the greatest stratification ability.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2016: Computer-Aided Diagnosis
ISBN (Electronic)9781510600201
StatePublished - 2016
EventMedical Imaging 2016: Computer-Aided Diagnosis - San Diego, United States
Duration: Feb 28 2016Mar 2 2016


OtherMedical Imaging 2016: Computer-Aided Diagnosis
CountryUnited States
CitySan Diego


  • Alzheimer's disease
  • Joint histogram
  • Lewy body disease
  • PET imaging
  • PiB
  • β-amyloid plaques

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

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