Quantitative assessment of the relationship between myocardial lesion formation detected by delayed contrast-enhanced magnetic resonance imaging and proton beam planning dose for treatment of ventricular tachycardia

M. E. Rettmann, A. Suzuki, A. J. Deisher, S. Hohmann, H. Konishi, S. Wang, J. J. Kruse, L. K. Newman, K. D. Parker, M. G. Herman, Douglas L Packer

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Proton beam therapy has recently been proposed as a noninvasive approach for treating ventricular tachycardia (VT), where target regions are identified in the myocardium and treated using external beam therapy. Effective treatment requires that lesions develop at target sites of myocardial tissue in order to stop arrhythmic pathways. Precise characterization of the dose required for lesion creation is required for determining appropriate dose levels in future clinical treatment of VT patients. In this work, we use a deformable registration algorithm to align proton beam delivery isodose lines planned from baseline computed-tomography scans to follow-up delayed contrast-enhanced magnetic resonance imaging scans in three swine studies. The relationship between myocardial lesion formation and delivered dose from external proton beam ablation therapy is then quantitatively assessed. The current study demonstrates that myocardial tissue receiving a dose of 20Gy or higher tends to develop into lesion, while tissue exposed to less than 10Gy of dose tends to remain healthy. Overall, this study quantifies the relationship between external proton beam therapy dose and myocardial lesion formation which is important for determining dose levels in future clinical treatment of VT patients.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2019
Subtitle of host publicationImage-Guided Procedures, Robotic Interventions, and Modeling
EditorsBaowei Fei, Cristian A. Linte
PublisherSPIE
ISBN (Electronic)9781510625495
DOIs
StatePublished - Jan 1 2019
EventMedical Imaging 2019: Image-Guided Procedures, Robotic Interventions, and Modeling - San Diego, United States
Duration: Feb 17 2019Feb 19 2019

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume10951
ISSN (Print)1605-7422

Conference

ConferenceMedical Imaging 2019: Image-Guided Procedures, Robotic Interventions, and Modeling
CountryUnited States
CitySan Diego
Period2/17/192/19/19

Fingerprint

tachycardia
Proton beams
Magnetic resonance
Proton Therapy
Ventricular Tachycardia
proton beams
lesions
magnetic resonance
planning
Protons
Magnetic Resonance Imaging
Tissue
Imaging techniques
Planning
dosage
therapy
Ablation
Tomography
Therapeutics
Myocardium

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Rettmann, M. E., Suzuki, A., Deisher, A. J., Hohmann, S., Konishi, H., Wang, S., ... Packer, D. L. (2019). Quantitative assessment of the relationship between myocardial lesion formation detected by delayed contrast-enhanced magnetic resonance imaging and proton beam planning dose for treatment of ventricular tachycardia. In B. Fei, & C. A. Linte (Eds.), Medical Imaging 2019: Image-Guided Procedures, Robotic Interventions, and Modeling [109510D] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 10951). SPIE. https://doi.org/10.1117/12.2513920

Quantitative assessment of the relationship between myocardial lesion formation detected by delayed contrast-enhanced magnetic resonance imaging and proton beam planning dose for treatment of ventricular tachycardia. / Rettmann, M. E.; Suzuki, A.; Deisher, A. J.; Hohmann, S.; Konishi, H.; Wang, S.; Kruse, J. J.; Newman, L. K.; Parker, K. D.; Herman, M. G.; Packer, Douglas L.

Medical Imaging 2019: Image-Guided Procedures, Robotic Interventions, and Modeling. ed. / Baowei Fei; Cristian A. Linte. SPIE, 2019. 109510D (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 10951).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Rettmann, ME, Suzuki, A, Deisher, AJ, Hohmann, S, Konishi, H, Wang, S, Kruse, JJ, Newman, LK, Parker, KD, Herman, MG & Packer, DL 2019, Quantitative assessment of the relationship between myocardial lesion formation detected by delayed contrast-enhanced magnetic resonance imaging and proton beam planning dose for treatment of ventricular tachycardia. in B Fei & CA Linte (eds), Medical Imaging 2019: Image-Guided Procedures, Robotic Interventions, and Modeling., 109510D, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 10951, SPIE, Medical Imaging 2019: Image-Guided Procedures, Robotic Interventions, and Modeling, San Diego, United States, 2/17/19. https://doi.org/10.1117/12.2513920
Rettmann ME, Suzuki A, Deisher AJ, Hohmann S, Konishi H, Wang S et al. Quantitative assessment of the relationship between myocardial lesion formation detected by delayed contrast-enhanced magnetic resonance imaging and proton beam planning dose for treatment of ventricular tachycardia. In Fei B, Linte CA, editors, Medical Imaging 2019: Image-Guided Procedures, Robotic Interventions, and Modeling. SPIE. 2019. 109510D. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE). https://doi.org/10.1117/12.2513920
Rettmann, M. E. ; Suzuki, A. ; Deisher, A. J. ; Hohmann, S. ; Konishi, H. ; Wang, S. ; Kruse, J. J. ; Newman, L. K. ; Parker, K. D. ; Herman, M. G. ; Packer, Douglas L. / Quantitative assessment of the relationship between myocardial lesion formation detected by delayed contrast-enhanced magnetic resonance imaging and proton beam planning dose for treatment of ventricular tachycardia. Medical Imaging 2019: Image-Guided Procedures, Robotic Interventions, and Modeling. editor / Baowei Fei ; Cristian A. Linte. SPIE, 2019. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE).
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